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Protein

Translation initiation factor IF-1

Gene

infA

Organism
Actinoplanes derwentensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factorUniRule annotationSAAS annotationImported, RNA-binding, rRNA-bindingUniRule annotationSAAS annotation
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1UniRule annotation
Gene namesi
Name:infAUniRule annotation
ORF Names:SAMN04489716_6113Imported
OrganismiActinoplanes derwentensisImported
Taxonomic identifieri113562 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes
Proteomesi
  • UP000198688 Componenti: Chromosome i

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A1H2CKW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73S1-likeInterPro annotationAdd BLAST73

Sequence similaritiesi

Belongs to the IF-1 family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd04451 S1_IF1, 1 hit
HAMAPiMF_00075 IF_1, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR004368 TIF_IF1
PANTHERiPTHR33370 PTHR33370, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00008 infA, 1 hit
PROSITEiView protein in PROSITE
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1H2CKW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKKDGAIEI EGRVIEPLPN AMFRVELANG HKVLAHISGK MRQHYIRILP
60 70
EDRVVVELSP YDLTRGRIVY RYK
Length:73
Mass (Da):8,485
Last modified:January 18, 2017 - v1
Checksum:iE4861C9BCB9D1E59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT629758 Genomic DNA Translation: SDT71205.1
RefSeqiWP_007073013.1, NZ_LT629758.1

Genome annotation databases

GeneIDi5704894

Similar proteinsi

Entry informationi

Entry nameiA0A1H2CKW4_9ACTN
AccessioniPrimary (citable) accession number: A0A1H2CKW4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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