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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Pseudomonas chengduensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transforms N2-succinylglutamate into succinate and glutamate.UniRule annotationSAAS annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-arginine degradation via AST pathway

This protein is involved in step 5 of the subpathway that synthesizes L-glutamate and succinate from L-arginine.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Arginine N-succinyltransferase (SAMN05216576_11458), Arginine N-succinyltransferase (SAMN05216576_11459)
  2. N-succinylarginine dihydrolase (astB)
  3. no protein annotated in this organism
  4. N-succinylglutamate 5-semialdehyde dehydrogenase (astD)
  5. Succinylglutamate desuccinylase (astE)
This subpathway is part of the pathway L-arginine degradation via AST pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate and succinate from L-arginine, the pathway L-arginine degradation via AST pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59ZincUniRule annotation1
Metal bindingi62ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Active sitei216UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processArginine metabolismUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00185;UER00283

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotationSAAS annotation (EC:3.5.1.96UniRule annotationSAAS annotation)
Gene namesi
Name:astEUniRule annotation
ORF Names:SAMN05216576_11454Imported
OrganismiPseudomonas chengduensisImported
Taxonomic identifieri489632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000199467 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd03855 M14_ASTE, 1 hit
HAMAPiMF_00767 Arg_catab_AstE, 1 hit
InterProiView protein in InterPro
IPR007036 Aste_AspA
IPR016681 SuccinylGlu_desuccinylase
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF017020 AstE, 1 hit
TIGRFAMsiTIGR03242 arg_catab_astE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1G6TSE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLALGKLLEL TLAGHEPSAK IQLTPDGTRL RWLDEGALEV TPPAARDNGL
60 70 80 90 100
DLLLSAGVHG NETAPIELLD RLLRGIARNE LHPAARILFL FGNPEAMRRG
110 120 130 140 150
ERYIEQDLNR LFSGRHEQSS GFEAIRACDL EHLAATFFGK QTGRTRLHYD
160 170 180 190 200
LHTAIRGSKI EQFALYPWQE GRAHSRRELE RLRAAGIEAV LLQNKSSITF
210 220 230 240 250
SAYTYAQLGA EAFTLELGKA RAFGQNELVN LDLLENALHA LIEGREVISG
260 270 280 290 300
EPTLDGLQLF SVSREVIKHS DSFQLHLPAD IENFTELEPG YLLAEDIADS
310 320 330
RWMVEEKGAR IIFPNPKVKN GLRAAILIVP DDGAGLL
Length:337
Mass (Da):37,407
Last modified:November 22, 2017 - v1
Checksum:i3EBFDDF258A6505A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FMZQ01000014 Genomic DNA Translation: SDD31396.1
RefSeqiWP_017677544.1, NZ_FMZQ01000014.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FMZQ01000014 Genomic DNA Translation: SDD31396.1
RefSeqiWP_017677544.1, NZ_FMZQ01000014.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00185;UER00283

Family and domain databases

CDDicd03855 M14_ASTE, 1 hit
HAMAPiMF_00767 Arg_catab_AstE, 1 hit
InterProiView protein in InterPro
IPR007036 Aste_AspA
IPR016681 SuccinylGlu_desuccinylase
PfamiView protein in Pfam
PF04952 AstE_AspA, 1 hit
PIRSFiPIRSF017020 AstE, 1 hit
TIGRFAMsiTIGR03242 arg_catab_astE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1G6TSE9_9PSED
AccessioniPrimary (citable) accession number: A0A1G6TSE9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: January 31, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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