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UniProtKB - A0A1G4H5I1 (A0A1G4H5I1_PLAVI)
Protein
Glycine hydroxymethyltransferase
Gene
PVC01_140059500
Organism
Plasmodium vivax
Status
Functioni
Cofactori
pyridoxal 5'-phosphateUniRule annotationARBA annotation
: tetrahydrofolate interconversion Pathwayi
This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.ARBA annotationView all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.
GO - Molecular functioni
- glycine hydroxymethyltransferase activity Source: UniProtKB-EC
- methyltransferase activity Source: UniProtKB-KW
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- glycine biosynthetic process from serine Source: InterPro
- methylation Source: UniProtKB-KW
- tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Keywordsi
Molecular function | MethyltransferaseImported, Transferase |
Ligand | Pyridoxal phosphateUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00193 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PVC01_140059500Imported, PVP01_1453700Imported, PVT01_140059000Imported |
Organismi | Plasmodium vivaxImported |
Taxonomic identifieri | 5855 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Plasmodium) |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PVP01_1453700 PlasmoDB:PVX_100730 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 237 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 393 | SHMTInterPro annotationAdd BLAST | 387 |
Sequence similaritiesi
Belongs to the SHMT family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG2467, Eukaryota |
OMAi | SHPAGLI |
Family and domain databases
CDDi | cd00378, SHMT, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_00051, SHMT, 1 hit |
InterProi | View protein in InterPro IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR001085, Ser_HO-MeTrfase IPR039429, SHMT-like_dom |
PANTHERi | PTHR11680, PTHR11680, 1 hit |
Pfami | View protein in Pfam PF00464, SHMT, 1 hit |
PIRSFi | PIRSF000412, SHMT, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A1G4H5I1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNNEPLEQI DKELHDILAD EEKRQRETIN LIASENLTNG AVRECLGNRV
60 70 80 90 100
SNKYSEGYPK KRYYGGNDFI DKIEELCQKR ALEAFNVSDE EWGVNVQPLS
110 120 130 140 150
GSAANVQALY ALVGVKGKIM GMHLCSGGHL THGFFDEKKK VSITSDMFES
160 170 180 190 200
KLYKCNSQGY VDLDAVREMA LSFKPKVIIC GYTSYPRDID YQQFRQICDE
210 220 230 240 250
VNAYLFADIS HISSFVACNI LNNPFLHADV VTTTTHKILR GPRSALIFFN
260 270 280 290 300
KKRNPGIEQK INSAVFPSFQ GGPHNNKIAA VACQLKEVHS PAFKEYTQQV
310 320 330 340 350
LLNSKALAKA LISKQIDLVT NGTDNHLIVV DLRKFSITGS KLQETCNAIN
360 370 380 390 400
VSLNKNTIPS DVDCVSPSGV RIGTPAMTTR GAKEKDMEFI ADVLARAIKI
410 420 430 440
TVDLQEQYGK KLVDFKKGLP GNAQLQQLKQ EVVTWAGALP FP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT615252 Genomic DNA Translation: SCO70112.1 LT615269 Genomic DNA Translation: SCO75603.1 LT635625 Genomic DNA Translation: VUZ99061.1 |
RefSeqi | XP_001613892.1, XM_001613842.1 |
Genome annotation databases
GeneIDi | 5473173 |
KEGGi | pvx:PVX_100730 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT615252 Genomic DNA Translation: SCO70112.1 LT615269 Genomic DNA Translation: SCO75603.1 LT635625 Genomic DNA Translation: VUZ99061.1 |
RefSeqi | XP_001613892.1, XM_001613842.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YFZ | X-ray | 2.16 | A/B/C | 1-442 | [»] | |
5YG2 | X-ray | 2.20 | A/B/C | 1-442 | [»] | |
5YG3 | X-ray | 2.40 | A/B/C | 1-442 | [»] | |
5YG4 | X-ray | 2.30 | A/B/C | 1-442 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 5473173 |
KEGGi | pvx:PVX_100730 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PVP01_1453700 PlasmoDB:PVX_100730 |
Phylogenomic databases
eggNOGi | KOG2467, Eukaryota |
OMAi | SHPAGLI |
Enzyme and pathway databases
UniPathwayi | UPA00193 |
Family and domain databases
CDDi | cd00378, SHMT, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_00051, SHMT, 1 hit |
InterProi | View protein in InterPro IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR001085, Ser_HO-MeTrfase IPR039429, SHMT-like_dom |
PANTHERi | PTHR11680, PTHR11680, 1 hit |
Pfami | View protein in Pfam PF00464, SHMT, 1 hit |
PIRSFi | PIRSF000412, SHMT, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1G4H5I1_PLAVI | |
Accessioni | A0A1G4H5I1Primary (citable) accession number: A0A1G4H5I1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 18, 2017 |
Last sequence update: | January 18, 2017 | |
Last modified: | May 25, 2022 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |