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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Chloroflexi bacterium RBG_16_57_8
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei583ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:A2147_01990Imported
OrganismiChloroflexi bacterium RBG_16_57_8Imported
Taxonomic identifieri1797652 [NCBI]
Taxonomic lineageiBacteriaChloroflexi
Proteomesi
  • UP000178359 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 184tRNA-synt_1gInterPro annotationAdd BLAST146
Domaini219 – 405tRNA-synt_1_2InterPro annotationAdd BLAST187
Domaini419 – 608tRNA-synt_1InterPro annotationAdd BLAST190
Domaini653 – 774Anticodon_1InterPro annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionUniRule annotationAdd BLAST11
Motifi580 – 584"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1F8QUL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKYTPQEI ERKWQAKWAE DKLYEVRDDD PRPKWYALTM FPYTSGDLHV
60 70 80 90 100
GHWYAMAPSD VHARFKRMQG YNVLHPMGFD AFGLPAENAA IKRGIHPRTW
110 120 130 140 150
TMQNIENMRR QLKSLGAIYD WDREVITCDP DYYRWTQWFF VKLFEHDLAY
160 170 180 190 200
RGKAQVNWCP KCQVVLANEQ VVGGLCWRCD TEVVRRDLEQ WLFRITRYAD
210 220 230 240 250
ELMQHEDIDW PERIKTMQRN WVGKSYGTEI SFGLDHPGVA EKEIRIFTTR
260 270 280 290 300
PDTTYGVTFF VLAPEHPLAA MLTAPERRAE VQAYVDRSRR LTDIERLSTE
310 320 330 340 350
KEKDGVFTGA YVTNRLNGEK VPVWIADYVL ATYGTGAVMA VPAHDERDFA
360 370 380 390 400
FAKSYGIPIR VVIAPPDWKG EELDQAYIEP GTMVNSGQFN GTSSEKGMAA
410 420 430 440 450
VTRFLEEKGW GKGTVSYRMR DWIISRQRYW GAPIPMVHCP KCGIVAVPEK
460 470 480 490 500
DLPVLLPDEA DFSHVGESPL KYDEKWVNTT CPKCGGAARR ETDTIDGFMC
510 520 530 540 550
SCWYFLRYCS PHYDKAAFDP QAVKHWMPVD IYTGGAEHAV MHLLYTRFFT
560 570 580 590 600
MAIRDMGLVD FGEPFGKLFN QGTIIADNQK MSKSRGNVVN PDEYVNDLGA
610 620 630 640 650
DTVRAYMMFI GPWDQGGDWS DTGISGISRW FNRVWSLALE EYKPGAMDED
660 670 680 690 700
SERALRRLTH QTIRRVTNDI DRMRFNTMLA ALMEFSNELS RISEAAQVSQ
710 720 730 740 750
AAWKEAISTL ILLLAPSAPH LAEELWARTG HEYSIHNQRG PKWDETLAKE
760 770 780 790 800
EEITLVVQVN GKVRDRLTVP ASVTEADAKA GALASEKVKA HLEGKQIANV
810
VYVAGRLVNV VVR
Length:813
Mass (Da):92,979
Last modified:February 15, 2017 - v1
Checksum:i849BE7F28DD006E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MGNT01000070 Genomic DNA Translation: OGO39153.1

Similar proteinsi

Entry informationi

Entry nameiA0A1F8QUL9_9CHLR
AccessioniPrimary (citable) accession number: A0A1F8QUL9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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