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Entry version 107 (26 Feb 2020)
Sequence version 1 (14 Nov 2006)
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Protein

Protein eyes shut

Gene

eys

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein eyes shut
Alternative name(s):
Protein spacemaker
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eysImported
Synonyms:spamImported
ORF Names:CG33955
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031414 eys

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 122CytoplasmicSequence analysisAdd BLAST122
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 2176ExtracellularSequence analysisAdd BLAST2033

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit a closed rhabdomere system, rhabdomeres within each ommatidium are fused to each other.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi521E → K in eys(734); fails to form an interrhabdomeral space. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003392361 – 2176Protein eyes shutAdd BLAST2176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi148 ↔ 158Sequence analysis
Disulfide bondi153 ↔ 168Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi170 ↔ 179Sequence analysis
Disulfide bondi186 ↔ 197Sequence analysis
Disulfide bondi191 ↔ 206Sequence analysis
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi208 ↔ 217Sequence analysis
Disulfide bondi224 ↔ 235Sequence analysis
Disulfide bondi229 ↔ 244Sequence analysis
Disulfide bondi246 ↔ 255Sequence analysis
Disulfide bondi262 ↔ 276Sequence analysis
Disulfide bondi270 ↔ 286Sequence analysis
Disulfide bondi288 ↔ 297Sequence analysis
Disulfide bondi304 ↔ 315Sequence analysis
Disulfide bondi309 ↔ 324Sequence analysis
Disulfide bondi326 ↔ 335Sequence analysis
Disulfide bondi342 ↔ 353Sequence analysis
Disulfide bondi347 ↔ 362Sequence analysis
Disulfide bondi364 ↔ 373Sequence analysis
Disulfide bondi380 ↔ 392Sequence analysis
Disulfide bondi386 ↔ 401Sequence analysis
Disulfide bondi403 ↔ 412Sequence analysis
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1022 ↔ 1033Sequence analysis
Disulfide bondi1027 ↔ 1042Sequence analysis
Disulfide bondi1044 ↔ 1053Sequence analysis
Glycosylationi1165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1176N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1313 ↔ 1324Sequence analysis
Disulfide bondi1318 ↔ 1334Sequence analysis
Disulfide bondi1336 ↔ 1345Sequence analysis
Glycosylationi1471N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1549 ↔ 1560Sequence analysis
Disulfide bondi1554 ↔ 1569Sequence analysis
Disulfide bondi1571 ↔ 1580Sequence analysis
Disulfide bondi1587 ↔ 1600Sequence analysis
Disulfide bondi1594 ↔ 1609Sequence analysis
Disulfide bondi1611 ↔ 1620Sequence analysis
Glycosylationi1665N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1861N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1879 ↔ 1890Sequence analysis
Disulfide bondi1884 ↔ 1900Sequence analysis
Disulfide bondi1902 ↔ 1911Sequence analysis
Disulfide bondi1917 ↔ 1928Sequence analysis
Disulfide bondi1922 ↔ 1934Sequence analysis
Disulfide bondi1936 ↔ 1945Sequence analysis
Glycosylationi1994N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2035N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2099N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A1F4

PRoteomics IDEntifications database

More...
PRIDEi
A0A1F4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A0A1F4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed from the beginning of rhabdomere biogenesis (48 hours after pupal formation), when it decorates the entire photoreceptor apical surface.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryonic, larval, and adult stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031414 Expressed in head and 9 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A1F4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A0A1F4 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
533487, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0112919

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 180EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini182 – 218EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini220 – 256EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini258 – 298EGF-like 4PROSITE-ProRule annotationAdd BLAST41
Domaini300 – 336EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini338 – 374EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini376 – 413EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini1018 – 1054EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini1059 – 1266Laminin G-like 1PROSITE-ProRule annotationAdd BLAST208
Domaini1309 – 1346EGF-like 9PROSITE-ProRule annotationAdd BLAST38
Domaini1353 – 1549Laminin G-like 2PROSITE-ProRule annotationAdd BLAST197
Domaini1545 – 1581EGF-like 10PROSITE-ProRule annotationAdd BLAST37
Domaini1583 – 1621EGF-like 11PROSITE-ProRule annotationAdd BLAST39
Domaini1692 – 1879Laminin G-like 3PROSITE-ProRule annotationAdd BLAST188
Domaini1875 – 1912EGF-like 12PROSITE-ProRule annotationAdd BLAST38
Domaini1913 – 1946EGF-like 13PROSITE-ProRule annotationAdd BLAST34
Domaini1952 – 2166Laminin G-like 4PROSITE-ProRule annotationAdd BLAST215

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi484 – 661Ser-richSequence analysisAdd BLAST178
Compositional biasi812 – 842His-richSequence analysisAdd BLAST31
Compositional biasi878 – 980Pro-richSequence analysisAdd BLAST103

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EYS family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
KOG3509 Eukaryota
ENOG410XS9U LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002251_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A0A1F4

KEGG Orthology (KO)

More...
KOi
K19601

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCEVDVA

Database of Orthologous Groups

More...
OrthoDBi
115967at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A1F4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 9 hits
PF02210 Laminin_G_2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 14 hits
SM00179 EGF_CA, 10 hits
SM00282 LamG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS00022 EGF_1, 14 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 13 hits
PS01187 EGF_CA, 4 hits
PS50025 LAM_G_DOMAIN, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNVHQFDTQ TMAESPQIRR DMGRLCATWP SKDSEDGAGT ALRAATPLTA
60 70 80 90 100
NGATTTGLSV TLAPKDMQRN HLLKMPTATI EKPTITATIA SSSSTSTSTT
110 120 130 140 150
RKSVTATRSL KLNPNILLPT LRILARGLLL PALILAILVG SSQAGFACLS
160 170 180 190 200
NPCVFGVCID GLNSSYSCYC IDGYTGIQCQ TNWDECWSSP CQNGGTCVDG
210 220 230 240 250
VAYYNCTCPE GFSGSNCEEN VDECMSNPCQ NGGLCRDRTN GYICTCQPGY
260 270 280 290 300
LGSHCELDVA VCETGTGARC QHGGECIEGP GLEFTCDCPA GWHGRICQEE
310 320 330 340 350
INECASSPCQ NGGVCVDKLA AYACACPMGY TGINCEEEIL ICADNPCQNN
360 370 380 390 400
ALCLMEEGVP TCYCVPDYHG EKCEFQYDEC QLGPRCMNGG VCIDGVDTFS
410 420 430 440 450
CSCPPLLTGM LCECLMVGEE SLDCNYTAPA TQSPPRRTTT TSTMAPPTVR
460 470 480 490 500
PVTPPETTVS PSRASEEVEI IVVTTSAPAE VVTSVLSPSS SSSSSEEGVS
510 520 530 540 550
VEIKTPTVAP PESGSHSISV EQTTAVPAQP EPESEQEPES KPHPESESAS
560 570 580 590 600
ESETETEEEI IPGTTARPPT SRSSSSSEES PSIFTTLPPL PGKPQTSASS
610 620 630 640 650
ESSGEVVTSE EYTTVPHFEV SGSKSESGSE EVTTVRPTAA PSITISVDIT
660 670 680 690 700
SSGSSSSSSE SVEVFTTPAP VFVQRVTTIE TSISIDYVTP TPLPETTTPR
710 720 730 740 750
VVPVPRPTFA PEPPLDVVET TASTHHLWTE VPTTAAPFFT EYPAEVLITT
760 770 780 790 800
HRTSAGRFTT VQPPAGVTTT SPTEDSSVEL PTPHTPQIVV TILDSNEVIP
810 820 830 840 850
SLITTTGSPT THHHHHHHPH HEAEGTTLQP LEEDEHHHHH HHDEFTTPQP
860 870 880 890 900
VEITTGHPLQ TEDLIGVQEP AVVTTESPFA PAETTVVPVV VPATIAPLGT
910 920 930 940 950
AAPPATPAPV PPATTTPPPS PPSLATETPT LPPTLPPVTL PPVTQPPPTI
960 970 980 990 1000
PPTPPSTQSA QTLPPPTSAI NVYTTPDGPP TASQTKPSVT ESSEEVEGTN
1010 1020 1030 1040 1050
TVSTGGRGSG GVPEEKAGDV DCIKLGCYNG GTCVTTSEGS RCVCRFDRQG
1060 1070 1080 1090 1100
PLCELPIIIR NAAFSGDSYV SHRIYKDIGG HESLDAVLPM HIQLKVRTRA
1110 1120 1130 1140 1150
TNGLIMLAAA QGTKGGHYMA LFLQKGLMQF QFSCGLQTML LSELETPVNT
1160 1170 1180 1190 1200
GHEITIRAEL DFSRNYTHCN ASLLVNDTLA MSGDQPTWLK LLPPRLHTPE
1210 1220 1230 1240 1250
AILNTWLHLG GAPQAPIGLI IELPPAQSGS GFTGCLHTLR INGQAREIFG
1260 1270 1280 1290 1300
DALDGFGITE CGSLACLSSP CRNGAACIKI ETNDLDENGE KAEKWKCKCP
1310 1320 1330 1340 1350
TGYMGPTCEI SVCEDNPCQY GGTCVQFPGS GYLCLCPLGK HGHYCEHNLE
1360 1370 1380 1390 1400
VALPSFSGSV NGLSSFVAYT VPIPLEYSLE LSFKILPQTM SQISLLAFFG
1410 1420 1430 1440 1450
QSGYHDEKSD HLAVSFIQGY IMLTWNLGAG PRRIFTQKPI DFRLDAPRVP
1460 1470 1480 1490 1500
YEIKVGRIGR QAWLSVDGKF NITGRSPGSG SRMDVLPILY LGGHEIANFN
1510 1520 1530 1540 1550
TLPHDLPLHS GFQGCIYDVQ LKAGQVTVPL QETRGVRGRG VGQCGTRECH
1560 1570 1580 1590 1600
RHACQHDGAC LQHGATFTCI CQEGWYGPLC AQPTNPCDSF NNKCYEDATC
1610 1620 1630 1640 1650
VPLVNGYECD CPVGRTGKNC EEVIRSLSDV SLTGRRSYLA VRWPYLYDGG
1660 1670 1680 1690 1700
DKLGAKRSQM VSYRNFTKKL MPPKPITTPS SHFVMKLLNE VEKQRSFSPV
1710 1720 1730 1740 1750
PLMGSKSFEE HHRVQFFFIE FQLRPLSERG LLLYFGTLNN NQDKKIGFVS
1760 1770 1780 1790 1800
LSLQGGVVEF RISGPSNHVT VVRSVRMLAI GEWHKIKMAQ RGRWLTLWVE
1810 1820 1830 1840 1850
GSASSALAPS AEVLVEPDSL LYIGGLKDVS KLPHNAISGF PIPFRGCVRG
1860 1870 1880 1890 1900
LVVSGTRIVL NETNIVESRN IRDCDGTACG GDSCESGGHC WLDEKLQPHC
1910 1920 1930 1940 1950
ICPEYAKGDR CEYSETCKLI PCKNNGRCLR SGRCSCPNGW GGFYCEIAMS
1960 1970 1980 1990 2000
KPTTPSFRGN SYLILPPPRI PMKDKRRGPS LYVRPREAIQ VSLNFSTIEP
2010 2020 2030 2040 2050
DGLLLWSEHE RSKFLGLGLE AGHLKLASNL LGSTNDTVRA PASGFIADGA
2060 2070 2080 2090 2100
WHWTSVLLDR SRLELQLDGE VIFTERLPEG GRSLGSTTPR STLAGRRKNS
2110 2120 2130 2140 2150
SKEPTISYED VFYLGGFPNS DSVSRRTKGR FFDPFKGCLQ DIQFGAEPTA
2160 2170
IISDFSTYQG ENIGSCDLHG DEPLTV
Length:2,176
Mass (Da):234,104
Last modified:November 14, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C21E204FCF3E311
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PBU9M9PBU9_DROME
Eyes shut, isoform E
eys 21A6, CG15388, CG15389, CG7245, CT35437
2,176Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence DAA03484 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ991915 mRNA Translation: ABJ09588.1
DQ780942 mRNA Translation: ABH07112.1
AE014134 Genomic DNA Translation: AAZ83988.3
AY119566 mRNA Translation: AAM50220.1
BK003285 Genomic DNA Translation: DAA03484.1 Sequence problems.

NCBI Reference Sequences

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RefSeqi
NP_001027571.3, NM_001032399.3
NP_001259924.2, NM_001272995.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0344662; FBpp0311004; FBgn0031414
FBtr0344663; FBpp0311005; FBgn0031414

Database of genes from NCBI RefSeq genomes

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GeneIDi
3771890

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG33955

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991915 mRNA Translation: ABJ09588.1
DQ780942 mRNA Translation: ABH07112.1
AE014134 Genomic DNA Translation: AAZ83988.3
AY119566 mRNA Translation: AAM50220.1
BK003285 Genomic DNA Translation: DAA03484.1 Sequence problems.
RefSeqiNP_001027571.3, NM_001032399.3
NP_001259924.2, NM_001272995.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi533487, 3 interactors
STRINGi7227.FBpp0112919

PTM databases

iPTMnetiA0A1F4

Proteomic databases

PaxDbiA0A1F4
PRIDEiA0A1F4

Genome annotation databases

EnsemblMetazoaiFBtr0344662; FBpp0311004; FBgn0031414
FBtr0344663; FBpp0311005; FBgn0031414
GeneIDi3771890
KEGGidme:Dmel_CG33955

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
346007
FlyBaseiFBgn0031414 eys

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG3509 Eukaryota
ENOG410XS9U LUCA
HOGENOMiCLU_002251_0_0_1
InParanoidiA0A1F4
KOiK19601
OMAiHCEVDVA
OrthoDBi115967at2759
PhylomeDBiA0A1F4

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3771890

Protein Ontology

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PROi
PR:A0A1F4

Gene expression databases

BgeeiFBgn0031414 Expressed in head and 9 other tissues
ExpressionAtlasiA0A1F4 baseline and differential
GenevisibleiA0A1F4 DM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00008 EGF, 9 hits
PF02210 Laminin_G_2, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00179 EGF_CA, 10 hits
SM00282 LamG, 4 hits
SUPFAMiSSF49899 SSF49899, 4 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS00022 EGF_1, 14 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 13 hits
PS01187 EGF_CA, 4 hits
PS50025 LAM_G_DOMAIN, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEYS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1F4
Secondary accession number(s): Q06PM7
, Q400N0, Q6IHY1, Q8MRJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: February 26, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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