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Entry version 24 (11 Dec 2019)
Sequence version 1 (15 Feb 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

A3F72_07000

Organism
Bacteroidetes bacterium RIFCSPLOWO2_12_FULL_35_15
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.SAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei28PROSITE-ProRule annotation1
Active sitei55PROSITE-ProRule annotation1
Active sitei147PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotationSAAS annotation
Biological processChemotaxisPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:A3F72_07000Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacteroidetes bacterium RIFCSPLOWO2_12_FULL_35_15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1797364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000176632 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11894-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei1351PhosphohistidinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphoproteinPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 204CheB-type methylesteraseInterPro annotationAdd BLAST189
Domaini221 – 464CheR-type methyltransferaseInterPro annotationAdd BLAST244
Domaini608 – 652PASInterPro annotationAdd BLAST45
Domaini679 – 731PACInterPro annotationAdd BLAST53
Domaini749 – 792PASInterPro annotationAdd BLAST44
Domaini805 – 859PACInterPro annotationAdd BLAST55
Domaini898 – 1119Histidine kinaseInterPro annotationAdd BLAST222
Domaini1140 – 1255Response regulatoryInterPro annotationAdd BLAST116
Domaini1312 – 1417HPtInterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1263 – 1293DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili533 – 570Sequence analysisAdd BLAST38
Coiled coili861 – 884Sequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CheB family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00082 HisKA, 1 hit
cd00130 PAS, 2 hits
cd00156 REC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.160, 1 hit
3.30.565.10, 1 hit
3.40.50.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035909 CheB_C
IPR022642 CheR_C
IPR000780 CheR_MeTrfase
IPR022641 CheR_N
IPR011006 CheY-like_superfamily
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR036641 HPT_dom_sf
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR029063 SAM-dependent_MTases
IPR008207 Sig_transdc_His_kin_Hpt_dom
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01339 CheB_methylest, 1 hit
PF01739 CheR, 1 hit
PF03705 CheR_N, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF13426 PAS_9, 2 hits
PF00072 Response_reg, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00996 CHERMTFRASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00138 MeTrc, 1 hit
SM00086 PAC, 2 hits
SM00091 PAS, 2 hits
SM00448 REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47226 SSF47226, 1 hit
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
SSF53335 SSF53335, 1 hit
SSF55785 SSF55785, 2 hits
SSF55874 SSF55874, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229 sensory_box, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50122 CHEB, 1 hit
PS50123 CHER, 1 hit
PS50109 HIS_KIN, 1 hit
PS50894 HPT, 1 hit
PS50113 PAC, 2 hits
PS50112 PAS, 2 hits
PS50110 RESPONSE_REGULATORY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1F3Q8I5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTGKNKKTF IKKTIKEKSF TVVAIGDSAG GLEAMSTLLK NLPSDTGMAF
60 70 80 90 100
IYVQHLCPDH KSFQTSILSK LTKMKVQEID NMELMKPNNV YIIPPNKEIK
110 120 130 140 150
VLDGHIQLTP RSKKNATSTI IDILFSSLAQ THKDNTIGVI LSGYANDGMA
160 170 180 190 200
GLKTIKDMGG VTFAQDDSAQ ASSMPYSVIA AGAVDYILSP KEIAKHLVRL
210 220 230 240 250
SKKMLPEKNR NKKQSEITVD SNPDLKTIFE ILHKKKGVDF RDYKMPTIKK
260 270 280 290 300
RLKYKMLLCG VETRKEYVNL LNKKTTEIDN LYNDLLINVT RFFRDKEVFA
310 320 330 340 350
YLKRTLLPKI INSKKTGETL RIWVPACSTG EEVYSIAMLI TELQDKKVKK
360 370 380 390 400
IPIQIFATDL SEQMIAEARI GMYSKTDLIN VSKKYVDRFF TKSGNSYQVV
410 420 430 440 450
KELREMCVFA PHNILQDPPF SRMDFISCRN LLIYFDAIAQ KRVFGTLHFT
460 470 480 490 500
LNEGGYLLLG KAETTGISSL LFNQANNKFK VYSRKKDIGL RKIPELIPHF
510 520 530 540 550
PSTNLNAKKA TILTKNTSVN PTGIEHAIDT SFISDANASN EEFQTLKEEL
560 570 580 590 600
EISKEEIEAT NEERLSTNQN LQIRNRLLSE SQEYSEAIIA SLIATKELEA
610 620 630 640 650
LNYSIKQASQ YPRSLLEASL DPLVTINSNG KITDVNEALI KVTGVQKNAL
660 670 680 690 700
IGTDFSNYFT ESEKAQEGYR HVFEKGFVAD YPLTIKHKNG ELTDVLYNAS
710 720 730 740 750
AFNDEIGNVL GVFAVARDIT EQKSVENSLE KSLRENSDYK YALDEFSIVA
760 770 780 790 800
ITDQKGIIKY VNDNFCKISK YNRSELIGQD HRIINSGYHP KEFIRELWKT
810 820 830 840 850
ITNGKIWKGE LYNRCKDGAF YWLDTTIVPF LNEKGKPYQY LSVRIDITEW
860 870 880 890 900
KRIEKEFTEA KIAAELATEV AEEAKRKAEN ETQIAMETVK SKQQFLSNMS
910 920 930 940 950
HEIRGPLNAI IGFTNAILKT RLDEKQKEYL DAIKVSGDAL IVLINDILDL
960 970 980 990 1000
AKVDAGKMTL ELAPFKLSSS ISSLLHLFEI TIQEKNLELV KEYDPAIPEF
1010 1020 1030 1040 1050
LLGDSARLNQ ILLNLISNAI KFTAAGKITV SVRMLKEETE EVTVEFAISD
1060 1070 1080 1090 1100
TGIGIHEKNL STIFDAFQQA TSETSRLYGG TGLGLAIVKK MVELKGGNIS
1110 1120 1130 1140 1150
VKSKVGKGST FSFILSFKKT DANEIICSSP DQDEEIKNVK VLVVENIVLN
1160 1170 1180 1190 1200
QLLMKTLLEE FGFDMDIADN GKIAIEKLKL NNYDIILMDL QMPEMNGFEA
1210 1220 1230 1240 1250
TEYIRKTMNS QIPIIALTAD VTTVDVEKCK AFKMNDYLAK PINEVLLKRK
1260 1270 1280 1290 1300
IIQLVKKKKE EENSVLKDQK NDQKKAEFSD HLKHENGNEG NVKESTTKKY
1310 1320 1330 1340 1350
IDLNYLKKLT KNTNGIIEMI EVYLEETPLL IDKLRQAIKT SDWESLRTTA
1360 1370 1380 1390 1400
HSLMPSFSMM GIDKEFEMDA KKIEEYAEML IEKKNMEPAE NEISVIKELF
1410 1420
LKIEEVCIHA SEELKIELIK
Length:1,420
Mass (Da):160,735
Last modified:February 15, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC956753A900CAA49
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
MEPB01000038 Genomic DNA Translation: OFY86194.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MEPB01000038 Genomic DNA Translation: OFY86194.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00082 HisKA, 1 hit
cd00130 PAS, 2 hits
cd00156 REC, 1 hit
Gene3Di1.20.120.160, 1 hit
3.30.565.10, 1 hit
3.40.50.180, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR022642 CheR_C
IPR000780 CheR_MeTrfase
IPR022641 CheR_N
IPR011006 CheY-like_superfamily
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR036641 HPT_dom_sf
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR029063 SAM-dependent_MTases
IPR008207 Sig_transdc_His_kin_Hpt_dom
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF01739 CheR, 1 hit
PF03705 CheR_N, 1 hit
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF13426 PAS_9, 2 hits
PF00072 Response_reg, 1 hit
PRINTSiPR00996 CHERMTFRASE
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00138 MeTrc, 1 hit
SM00086 PAC, 2 hits
SM00091 PAS, 2 hits
SM00448 REC, 1 hit
SUPFAMiSSF47226 SSF47226, 1 hit
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
SSF53335 SSF53335, 1 hit
SSF55785 SSF55785, 2 hits
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50123 CHER, 1 hit
PS50109 HIS_KIN, 1 hit
PS50894 HPT, 1 hit
PS50113 PAC, 2 hits
PS50112 PAS, 2 hits
PS50110 RESPONSE_REGULATORY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1F3Q8I5_9BACT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1F3Q8I5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: December 11, 2019
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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