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Protein

Urease subunit alpha

Gene

ureC

Organism
Proteus sp. HMSC14B05
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotationSAAS annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit beta (ureB), Urease subunit gamma (ureA), Urease subunit alpha (ureC)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi136Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi217Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi217Nickel 2; via carbamate groupUniRule annotation1
Binding sitei219SubstrateUniRule annotation1
Metal bindingi246Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi272Nickel 2; via tele nitrogenUniRule annotation1
Active sitei320Proton donorUniRule annotation1
Metal bindingi360Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NickelUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotationImported
ORF Names:HMPREF3129_14485Imported
OrganismiProteus sp. HMSC14B05Imported
Taxonomic identifieri1581097 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000177296 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Structurei

3D structure databases

SMRiA0A1F2K038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 567UreaseInterPro annotationAdd BLAST439

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1F2K038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTISRQAYA DMFGPTTGDR LRLADTELFL EIEKDFTTYG EEVKFGGGKV
60 70 80 90 100
IRDGMGQSQV VSAECVDVLI TNAIILDYWG IVKADIGIKD GRIVGIGKAG
110 120 130 140 150
NPDVQPNVDI VIGPGTEVVA GEGKIVTAGG IDTHIHFICP QQAQEGLVSG
160 170 180 190 200
VTTFIGGGTG PVAGTNATTV TPGIWNMYRM LEAVDELPIN VGLFGKGCVS
210 220 230 240 250
QPEAIREQIT AGAIGLKIHE DWGATPMAIH NCLNVADEMD VQVAIHSDTL
260 270 280 290 300
NEGGFYEETV KAIAGRVIHV FHTEGAGGGH APDVIKSVGE PNILPASTNP
310 320 330 340 350
TMPYTINTVD EHLDMLMVCH HLDPSIPEDV AFAESRIRRE TIAAEDILHD
360 370 380 390 400
MGAISVMSSD SQAMGRVGEV ILRTWQCAHK MKLQRGTLAG DSADNDNNRI
410 420 430 440 450
KRYIAKYTIN PALAHGIAHT VGSIEKGKLA DIVLWDPAFF GVKPALIIKG
460 470 480 490 500
GMVAYAPMGD INAAIPTPQP VHYRPMYACL GKAKYQTSMI FMSKAGIEAG
510 520 530 540 550
VPEKLGLKSL IGRVEGCRHI TKASMIHNNY VPHIELDPQT YIVKADGVPL
560
VCEPATELPM AQRYFLF
Length:567
Mass (Da):60,927
Last modified:February 15, 2017 - v1
Checksum:iE7747728624EC549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUAI01000067 Genomic DNA Translation: OFV15479.1
RefSeqiWP_004245262.1, NZ_KV792000.1

Genome annotation databases

GeneIDi6801207

Similar proteinsi

Entry informationi

Entry nameiA0A1F2K038_9GAMM
AccessioniPrimary (citable) accession number: A0A1F2K038
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: May 23, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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