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Protein

Pantothenate synthetase

Gene

panC

Organism
Methyloceanibacter methanicus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotationSAAS annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotationSAAS annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton donorUniRule annotation1
Binding sitei65Beta-alanineUniRule annotation1
Binding sitei65PantoateUniRule annotation1
Binding sitei157PantoateUniRule annotation1
Binding sitei180ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPUniRule annotation8
Nucleotide bindingi151 – 154ATPUniRule annotation4
Nucleotide bindingi188 – 191ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processPantothenate biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
ORF Names:AUC68_09780Imported
OrganismiMethyloceanibacter methanicusImported
Taxonomic identifieri1774968 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethyloceanibacter
Proteomesi
  • UP000094501 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1E3VZI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEIETVRT VADLRARVSA WRARGGSLAM VPTMGAIHEG HMSLVRQAKG
60 70 80 90 100
LAGHVVASIF VNPLQFGPSE DFEAYPRGEA RDAALLAEAG ADLLFAPGAG
110 120 130 140 150
EMYPEGFATT VHVADITEGL CGASRPDHFD GVATVVAKLL LQCGPDVAIF
160 170 180 190 200
GEKDYQQLLV IKRLVRDLNI PVKIVGGAIV REPDGLALSS RNAYLSAEER
210 220 230 240 250
ETAPLLYATI QQAAHALAAG HATEHALESA RAALEAAGFR VDYLEARDPE
260 270 280
TLARLSGSVA TARILVAAFL GKTRLIDNVP VPPRA
Length:285
Mass (Da):30,179
Last modified:January 18, 2017 - v1
Checksum:i8D0388A997FF681B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LPWG01000013 Genomic DNA Translation: ODR98671.1
RefSeqiWP_069438129.1, NZ_LPWG01000013.1

Genome annotation databases

EnsemblBacteriaiODR98671; ODR98671; AUC68_09780

Similar proteinsi

Entry informationi

Entry nameiA0A1E3VZI4_9RHIZ
AccessioniPrimary (citable) accession number: A0A1E3VZI4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: October 25, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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