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Protein

NADPH--cytochrome P450 reductase

Gene

NCP1

Organism
Lipomyces starkeyi NRRL Y-11557
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADUniRule annotationNote: Binds 1 FAD per monomer.UniRule annotation
  • FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei203FMNUniRule annotation1
Binding sitei294NADPUniRule annotation1
Binding sitei551NADPUniRule annotation1
Binding sitei655NADPUniRule annotation1
Binding sitei693FADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 77FMNUniRule annotation6
Nucleotide bindingi123 – 126FMNUniRule annotation4
Nucleotide bindingi168 – 177FMNUniRule annotation10
Nucleotide bindingi450 – 453FADUniRule annotation4
Nucleotide bindingi468 – 470FADUniRule annotation3
Nucleotide bindingi485 – 488FADUniRule annotation4
Nucleotide bindingi613 – 614NADPUniRule annotation2
Nucleotide bindingi619 – 623NADPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism
LigandFADUniRule annotation, Flavoprotein, FMNUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH--cytochrome P450 reductaseUniRule annotation (EC:1.6.2.4UniRule annotation)
Short name:
CPRUniRule annotation
Short name:
P450RUniRule annotation
Gene namesi
Name:NCP1UniRule annotation
ORF Names:LIPSTDRAFT_70234Imported
OrganismiLipomyces starkeyi NRRL Y-11557Imported
Taxonomic identifieri675824 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesLipomycetaceaeLipomyces
Proteomesi
  • UP000094385 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Cell membraneUniRule annotation, Endoplasmic reticulumUniRule annotation, Membrane, Mitochondrion, Mitochondrion outer membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 220Flavodoxin-likeInterPro annotationAdd BLAST155
Domaini275 – 523FAD-binding FR-typeInterPro annotationAdd BLAST249

Sequence similaritiesi

Belongs to the NADPH--cytochrome P450 reductase family.UniRule annotation
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.UniRule annotation
In the N-terminal section; belongs to the flavodoxin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

Gene3Di1.20.990.10, 1 hit
3.40.50.360, 1 hit
HAMAPiMF_03212 NCPR, 1 hit
InterProiView protein in InterPro
IPR003097 FAD-binding_1
IPR017927 Fd_Rdtase_FAD-bd
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR001433 OxRdtase_FAD/NAD-bd
IPR023208 P450R
IPR017938 Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF00667 FAD_binding_1, 1 hit
PF00258 Flavodoxin_1, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF000208 P450R, 1 hit
PRINTSiPR00369 FLAVODOXIN
PR00371 FPNCR
SUPFAMiSSF52218 SSF52218, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit
PS50902 FLAVODOXIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1E3QA76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQIDAFDIF ILGAVLVGTV AYFTKGALWG KRRTASALVG KSNGAAVAST
60 70 80 90 100
ATRSIITKLQ DSDRDVVVFY GSQTGTAEDY ASRLAKEGHS RFGLKTMVAD
110 120 130 140 150
IEEYDLEDLD TFPEDKVAIF VMATYGEGEP TDNAVAFYEF ITGDDPTFSE
160 170 180 190 200
MEDPEQPLKN LKYVAFGLGN NTYEHYNAII THLNEALLKL GARRIGEVGM
210 220 230 240 250
GDDGAGTMEE DFLSWKEEMW SEFANHVGVQ EREAVYEPAL KVEESELTIE
260 270 280 290 300
DANVYLGEFN KGHLQGTESS PFLPHNPYIA PITLCRELFK SDSRNCLHVE
310 320 330 340 350
IDLQDSNLKF TTGDHIAVWP QNSDKEVDRF LSVLGLTSKR DDVINVTPID
360 370 380 390 400
PTTKVPFPNP TTYDTVIRYH LEICGVVSRQ FLASLAPFAP SDEAKAEITK
410 420 430 440 450
LGNLKDYFSE VVSSRYLNIA QVLERISCGA TWSSVPFSLI VESINHIQPR
460 470 480 490 500
YYSISSSSYV DKTKPHITVV VESVPTTADA DPLKGVASNY LLDLRYKREG
510 520 530 540 550
IKNPSPSAVS YTTDGPRGRY KGNKIPVHIR HSNFKLPSNP AAPIIMVGPG
560 570 580 590 600
TGVAPFRAFV HERAAQAEAG VPVGTSLLFF GSRNRTEDFL YSEEWEALGE
610 620 630 640 650
KLGERFKLVT AFSRQGPEKV YVQHRLVENA ELVNKLLQDG AYFYVCGDAS
660 670 680 690
RMAKDVSASL AKIIAEQRGI AEEQGEEIVK SMRAQNLYQE DVWS
Length:694
Mass (Da):76,902
Last modified:January 18, 2017 - v1
Checksum:iECBE8F22366664EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV454292 Genomic DNA Translation: ODQ74566.1

Genome annotation databases

EnsemblFungiiODQ74566; ODQ74566; LIPSTDRAFT_70234

Similar proteinsi

Entry informationi

Entry nameiA0A1E3QA76_LIPST
AccessioniPrimary (citable) accession number: A0A1E3QA76
Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: March 28, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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