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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacillus velezensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:BK055_15805Imported, C0W57_13125Imported, C5O26_20470Imported, CU084_16155Imported
OrganismiBacillus velezensisImported
Taxonomic identifieri492670 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000239383 Componenti: Unassembled WGS sequence
  • UP000236378 Componenti: Chromosome
  • UP000176354 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 112HelicalUniRule annotationAdd BLAST24
Transmembranei124 – 143HelicalUniRule annotationAdd BLAST20
Transmembranei195 – 216HelicalUniRule annotationAdd BLAST22
Transmembranei228 – 249HelicalUniRule annotationAdd BLAST22
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

KOiK06153

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1D9PQT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLWEMFTAA VLGIVEGLTE YAPVSSTGHM IIADDIWLKS GSLMNPEAAN
60 70 80 90 100
SFKVVIQLGS ILAVAIVFKD RILHLLGLKK NVTRDQQKGY RLTIAQIAVG
110 120 130 140 150
LVPAAVLGFL FEDFIDRYLF SVRTVAYGLI AGAVLMLIAD WINKRKETID
160 170 180 190 200
TVDRITYKQA FCVGLFQCLA LWPGFSRSGS TIAGGVIVGL NHRAAADFTF
210 220 230 240 250
IMAIPIMAGA SLLKLVKYWS SLSYDMIPFF LVGFICAFVV ALLVVKFFLR
260 270
LINRIKLVPF AIYRVILGII LIMLVR
Length:276
Mass (Da):30,532
Last modified:February 15, 2017 - v1
Checksum:iB4CC505EE2E13FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017775 Genomic DNA Translation: APA04984.1
CP024922 Genomic DNA Translation: ATX85323.1
CP025939 Genomic DNA Translation: AUS18769.1
PTTN01000086 Genomic DNA Translation: PQB09778.1
RefSeqiWP_007613337.1, NZ_PVRO01000009.1

Genome annotation databases

KEGGibmp:NG74_02970

Similar proteinsi

Entry informationi

Entry nameiA0A1D9PQT2_9BACI
AccessioniPrimary (citable) accession number: A0A1D9PQT2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2017
Last sequence update: February 15, 2017
Last modified: July 18, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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