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Entry version 22 (12 Aug 2020)
Sequence version 1 (18 Jan 2017)
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Protein

Leucyl-tRNA synthetase

Gene

CDC60

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetaseARBA annotation, Ligase
Biological processProtein biosynthesisARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucyl-tRNA synthetaseARBA annotation (EC:6.1.1.4ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDC60Imported
Ordered Locus Names:CAALFM_CR01690CAImported, orf19.2560Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome R

Organism-specific databases

Candida Genome Database

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CGDi
CAL0000201312, CDC60

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CR_01690C_A

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5476.C4YL05

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1D8PS12

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 115tRNA-synt_1InterPro annotationAdd BLAST67
Domaini199 – 771tRNA-synt_1InterPro annotationAdd BLAST573
Domaini810 – 939Anticodon_1InterPro annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 162DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi128 – 159PolyampholyteSequence analysisAdd BLAST32

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0437, Eukaryota

KEGG Orthology (KO)

More...
KOi
K01869

Database of Orthologous Groups

More...
OrthoDBi
75155at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002300, aa-tRNA-synth_Ia
IPR004493, Leu-tRNA-synth_Ia_arc/euk
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit

The PANTHER Classification System

More...
PANTHERi
PTHR45794, PTHR45794, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00395, leuS_arch, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1D8PS12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGPVTFEKT FRRDALIDIE KKYQKVWAEE KVFEVDAPTF EECPIEDVEQ
60 70 80 90 100
VQEAHPKFFA TMAYPYMNGV LHAGHAFTLS KVEFATGFQR MNGKRALFPL
110 120 130 140 150
GFHCTGMPIK AAADKIKREV ELFGSDFSKA PADDEDAEES QQPAKTETKR
160 170 180 190 200
EDVTKFSSKK SKAAAKQGRA KFQYEIMMQL GIPREEVAKF ANTDYWLEFF
210 220 230 240 250
PPLCQKDVTA FGARVDWRRS MITTDANPYY DAFVRWQINR LRDVGKIKFG
260 270 280 290 300
ERYTIYSEKD GQACLDHDRQ SGEGVGPQEY VGIKIRLTDV APQAQELFKK
310 320 330 340 350
ENLDVKENKV YLVAATLRPE TMYGQTCCFV SPKIDYGVFD AGNGDYFITT
360 370 380 390 400
ERAFKNMSFQ NLTPKRGYYK PLFIINGKTL IGSRIDAPYA VNKNLRVLPM
410 420 430 440 450
ETVLATKGTG VVTCVPSDSP DDFVTTRDLA NKPEYYGIEK DWVQTDIVPI
460 470 480 490 500
VHTEKYGDKC AEFLVNDLKI QSPKDSVQLA NAKELAYKEG FYNGTMLIGK
510 520 530 540 550
YKGDKVEDAK PKVKQDLIDE GLAFVYNEPE SQVISRSGDD CCVSLEDQWY
560 570 580 590 600
IDYGEEAWLG EALECLKNME TYSKETRHGF EGVLAWMKNW AVTRKFGLGT
610 620 630 640 650
KLPWDPQYLV ESLSDSTVYM AYYTIDRFLH SDYYGKKAGK FDIKPEQMTD
660 670 680 690 700
EVFDYIFTRR DDVETDIPKE QLKEMRREFE YFYPLDVRVS GKDLIPNHLT
710 720 730 740 750
FFIYTHVALF PKRFWPRGVR ANGHLLLNNA KMSKSTGNFM TLEQIIEKFG
760 770 780 790 800
ADASRIAMAD AGDTVEDANF DEANANAAIL RLTTLKDWCE EEVKNQDKLR
810 820 830 840 850
TGDYDSFFDA AFENEMNDLI EKTYQQYTLS NYKQALKSGL FDFQIARDIY
860 870 880 890 900
RESVNTTGIG MHKDLVLKYI EYQALMLAPI APHFAEYLYR EVLGKNGSVQ
910 920 930 940 950
TSKFPRASKP VSKAILDASE YVRSLTRSIR EAEGQALKKK KGKSDVDGSK
960 970 980 990 1000
PISLTVLVSN TFPEWQDNYI ELVRELFEQN KLDDNNVIRQ KVGKDMKRGM
1010 1020 1030 1040 1050
PYIHQIKTRL ATEDADTVFN RKLTFDEIDT LKNVVEIVKN APYSLKVEKL
1060 1070 1080 1090
EILSFNNGET KGKNIISGED NIELNFKGKI MENAVPGEPG IFIKNVE
Length:1,097
Mass (Da):125,411
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB18DF3D7A8281787
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW30928.1

NCBI Reference Sequences

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RefSeqi
XP_718229.2, XM_713136.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
3640128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_CR01690CA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017630 Genomic DNA Translation: AOW30928.1
RefSeqiXP_718229.2, XM_713136.2

3D structure databases

SMRiA0A1D8PS12
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5476.C4YL05

Genome annotation databases

GeneIDi3640128
KEGGical:CAALFM_CR01690CA

Organism-specific databases

CGDiCAL0000201312, CDC60
EuPathDBiFungiDB:CR_01690C_A

Phylogenomic databases

eggNOGiKOG0437, Eukaryota
KOiK01869
OrthoDBi75155at2759

Family and domain databases

InterProiView protein in InterPro
IPR002300, aa-tRNA-synth_Ia
IPR004493, Leu-tRNA-synth_Ia_arc/euk
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR45794, PTHR45794, 1 hit
PfamiView protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 2 hits
SUPFAMiSSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit
TIGRFAMsiTIGR00395, leuS_arch, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1D8PS12_CANAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D8PS12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 18, 2017
Last sequence update: January 18, 2017
Last modified: August 12, 2020
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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