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Entry version 24 (02 Jun 2021)
Sequence version 1 (18 Jan 2017)
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Protein

Glycerophosphocholine phosphodiesterase GDE1

Gene

GDE1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline (PubMed:24114876).

The choline is used for phosphatidyl-choline synthesis (PubMed:24114876).

Required for utilization of glycerophosphocholine as phosphate source (PubMed:24114876).

C.albicans can utilize GroPCho through transport and intracellular hydrolysis or through extracellular hydrolysis (PubMed:24114876).

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycerophosphocholine phosphodiesterase GDE11 Publication (EC:3.1.4.21 Publication)
Alternative name(s):
Glycerophosphodiester phosphodiesterase GDE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GDE11 Publication
Ordered Locus Names:CAALFM_C504510WA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000191313, GDE1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:C5_04510W_A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Results in altered glycerophosphocholine catabolism (PubMed:24114876). Leads to hypersensitivity to 5-fluorouracil (5-FU) (PubMed:17604452).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004398021 – 1162Glycerophosphocholine phosphodiesterase GDE1Add BLAST1162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by the transcription factor PHO4 (PubMed:24114876). Induced during early phase of biofilm formation (PubMed:16151249).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5476.C4YRW3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 155SPXPROSITE-ProRule annotationAdd BLAST155
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati346 – 375ANK 1Sequence analysisAdd BLAST30
Repeati392 – 421ANK 2Sequence analysisAdd BLAST30
Repeati423 – 452ANK 3Sequence analysisAdd BLAST30
Repeati458 – 487ANK 4Sequence analysisAdd BLAST30
Repeati492 – 521ANK 5Sequence analysisAdd BLAST30
Repeati525 – 554ANK 6Sequence analysisAdd BLAST30
Domaini817 – 1146GP-PDEPROSITE-ProRule annotationAdd BLAST330

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDE1 family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota
KOG1162, Eukaryota
KOG2421, Eukaryota

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSTQLDT

Database of Orthologous Groups

More...
OrthoDBi
687958at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR033506, Gde1
IPR030395, GP_PDE_dom
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR004331, SPX_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22958:SF1, PTHR22958:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF03009, GDPD, 1 hit
PF03105, SPX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits
PS51704, GP_PDE, 1 hit
PS51382, SPX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1D8PNZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFGKTYVTH QIPEWSIYYM NYKQLKKIIK SIDSAANTNV DESKYPEVIS
60 70 80 90 100
DTLGSFFYDL DRDIEKVDSF YNTKFKEYNR RLNKIFQVLG YQDGQITHNI
110 120 130 140 150
ESSEELDEII NILIELKSLF RNLKWFAELN HKGFIKILKK LDKKLTSILS
160 170 180 190 200
QHSGVSVGGV SNHNQEAYMG SRINALPFAN GTEASNCLDS IHHILSRIET
210 220 230 240 250
RNDVVQETIP VENNETSISA LIKNDDFEGL KKHITIKSSQ KFLISTLNKA
260 270 280 290 300
ALANSTKCID VIWNQLDMLY DDSDFNGRNF FHQHIISLGK AQFIREEQIV
310 320 330 340 350
PGEVTNRLIG GDNGPDNSNK NDNPIGLLYI LNKLKHKRLI LAEDHYHRTP
360 370 380 390 400
LHYASQYGLV EVTRYLVEFG VKWGLINTSI SIDDVSIWGD QEGLTPLHLS
410 420 430 440 450
IIGKHPKTTE TLLGFNKAQT LTCPNLLLLA VRLNSPQILN SLIVEGNIDV
460 470 480 490 500
NYTDIDHRNE TALYIASKLN HPDLVEFLLE SNANTEIGEN VFGWTPIFIA
510 520 530 540 550
ASEGFMTIVK LLKEYGASYD IVDDSGWLPM EHACLRGHLD VTDLLLPKNE
560 570 580 590 600
KLLLYDMYHP ENNLPRIPSL AASPVLTGSD DGTVSTSSID KLPEPQKNTV
610 620 630 640 650
NQFYKQLKNN SSNNVSRSTS PKRNKRYKPV KSFGHRYLNE DESLILLTLG
660 670 680 690 700
TTDLRDTNVP VELNKVSLAK SFATELDTAL SLSITCRHKL TNNPVEPPVV
710 720 730 740 750
VDLPLEDFHG SATDPISFKL SNDLTVNDVI ITFDIIPTYQ VNKKVIGRAI
760 770 780 790 800
ALLKDAYTKV GPNLRSLNNS IAIPIIESTN LDILGTIRFE YLQVLPFKHK
810 820 830 840 850
AMSIARSDTY WKQLVSTRVI GHRGLGKNLS GKKSLQLGEN TVESFIAAAS
860 870 880 890 900
LGASYVEFDV QLTKDHVPVV YHDFTVAESG VDIPMHLLTL EQFMGFNTPT
910 920 930 940 950
EKPTHTVDDE VLTRGKQRAQ SSYQLSNNHN DDIEKEFANQ RDERMKFTKT
960 970 980 990 1000
WKNQGYKGNL RGSSVASNFV TLRELFRKLP NNVGFNIEVK YPMLDEAQLE
1010 1020 1030 1040 1050
DMGEIGVDLN FFVDTILKVI YDENTTGRDI VFSSFHPDIC LLLSLKQPTM
1060 1070 1080 1090 1100
PVLFLTEAGT APMYDIRASS LQNAVRFSKK WNLLGIVSNA LALIKTPRLA
1110 1120 1130 1140 1150
QVVKSMGLVC VTYGTENNEP ELAKIQMRAG VDAVIVDSVL AVREGLREHN
1160
ETMNEFEDSP TE
Length:1,162
Mass (Da):130,854
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFB280D9215A1F0C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP017627 Genomic DNA Translation: AOW29857.1

NCBI Reference Sequences

More...
RefSeqi
XP_721845.1, XM_716752.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3636505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_C504510WA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017627 Genomic DNA Translation: AOW29857.1
RefSeqiXP_721845.1, XM_716752.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5476.C4YRW3

Genome annotation databases

GeneIDi3636505
KEGGical:CAALFM_C504510WA

Organism-specific databases

CGDiCAL0000191313, GDE1
VEuPathDBiFungiDB:C5_04510W_A

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
KOG1162, Eukaryota
KOG2421, Eukaryota
OMAiHSTQLDT
OrthoDBi687958at2759

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR033506, Gde1
IPR030395, GP_PDE_dom
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR004331, SPX_dom
PANTHERiPTHR22958:SF1, PTHR22958:SF1, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF03009, GDPD, 1 hit
PF03105, SPX, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits
PS51704, GP_PDE, 1 hit
PS51382, SPX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDE1_CANAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D8PNZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: January 18, 2017
Last modified: June 2, 2021
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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