UniProtKB - A0A1D5RLU3 (A0A1D5RLU3_MOUSE)
Protein
Voltage-dependent R-type calcium channel subunit alpha
Gene
Cacna1e
Organism
Mus musculus (Mouse)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent R-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:Cacna1eImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106217, Cacna1e |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 25 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 119 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 160 – 182 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 234 – 255 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 267 – 289 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 416 – 436 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 442 – 460 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 542 – 564 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 619 – 642 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1093 – 1112 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 1165 – 1184 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 1230 – 1252 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1342 – 1367 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1423 – 1441 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1453 – 1476 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1482 – 1500 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1547 – 1565 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1640 – 1664 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
ProteomicsDBi | 366012 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1680 – 1715 | EF-handInterPro annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 668 – 715 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 792 – 932 | DisorderedSequence analysisAdd BLAST | 141 | |
Regioni | 1029 – 1065 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1899 – 2170 | DisorderedSequence analysisAdd BLAST | 272 | |
Regioni | 2203 – 2254 | DisorderedSequence analysisAdd BLAST | 52 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 638 – 665 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 684 – 704 | PolyampholyteSequence analysisAdd BLAST | 21 | |
Compositional biasi | 889 – 922 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 1036 – 1065 | PolyampholyteSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1899 – 1926 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1946 – 1960 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1961 – 1975 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2006 – 2063 | PolyampholyteSequence analysisAdd BLAST | 58 | |
Compositional biasi | 2064 – 2097 | PolarSequence analysisAdd BLAST | 34 | |
Compositional biasi | 2136 – 2166 | PolarSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155601 |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005449, VDCC_R_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF5, PTHR45628:SF5, 1 hit |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01633, RVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
A0A1D5RLU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVHPFISAPN FVSVTPSMGV LFPILRRGIV STLQSSFFLS FMCLANCILY
60 70 80 90 100
LGYPRFWANI HLSEKTEPYF IGIFCFEAGI KIVALGFIFH KGSYLRNGWN
110 120 130 140 150
VMDFIVVLSG ILATAGTHFN THVDLRTLRA VRVLRPLKLV SGIPSLQIVL
160 170 180 190 200
KSIMKAMVPL LQIGLLLFFA ILMFAIIGLE FYSGKLHRAC FMNNSGILEG
210 220 230 240 250
FDPPHPCGVQ GCPAGYECKD WIGPNDGITQ FDNILFAVLT VFQCITMEGW
260 270 280 290 300
TTVLYNTNDA LGATWNWLYF IPLIIIGSFF VLNLVLGVLS GEFAKERERV
310 320 330 340 350
ENRRAFMKLR RQQQIERELN GYRAWIDKAE EVMLAEENKN SGTSALEVLR
360 370 380 390 400
RATIKRSRTE AMTRDSSDEH CVDISSVGTP LARASIKSTK VDGASYFRHK
410 420 430 440 450
ERLLRISIRH MVKSQVFYWI VLSVVALNTA CVAIVHHNQP QWLTHLLYYA
460 470 480 490 500
EFLFLGLFLL EMSLKMYGMG PRLYFHSSFN CFDFGVTVGS IFEVVWAIFR
510 520 530 540 550
PGTSFGISVL RALRLLRIFK ITKYWASLRN LVVSLMSSMK SIISLLFLLF
560 570 580 590 600
LFIVVFALLG MQLFGGRFNF NDGTPSANFD TFPAAIMTVF QILTGEDWNE
610 620 630 640 650
VMYNGIRSQG GVSSGMWSAI YFIVLTLFGN YTLLNVFLAI AVDNLANAQE
660 670 680 690 700
LTKDEQEEEE AFNQKHALQK AKEVSPMSAP NMPSIERDRR RRHHMSMWEP
710 720 730 740 750
RSSHLRERRR RHHMSVWEQR TSQLRRHMQM SSQEALNKEE APPMNPLNPL
760 770 780 790 800
NPLSPLNPLN AHPSLYRRPR PIEGLALGLG LEKCEEERIS RGGSLKGDIG
810 820 830 840 850
GLTSALDNQR SPLSLGKREP PWLPRSCHGN CDPIQQEAGG GETVVTFEDR
860 870 880 890 900
ARHRQSQRRS RHRRVRTEGK DSASASRSRS ASQERSLDEG VSVEGEKEHE
910 920 930 940 950
PHSSHRSKEP TIHEEERTQD LRRTNSLMVP RGSGLVGALD EAETPLVQPQ
960 970 980 990 1000
PELEVGKDAA LTEQEAEGSS EQALLGDVQL DVGRGISQSE PDLSCMTANM
1010 1020 1030 1040 1050
DKATTESTSV TVAIPDVDPL VDSTVVNISN KTDGEASPLK EAETKEEEEE
1060 1070 1080 1090 1100
VEKKKKQKKE KRETGKAMVP HSSMFIFSTT NPIRRACHYI VNLRYFEMCI
1110 1120 1130 1140 1150
LLVIAASSIA LAAEDPVLTN SERNKVLRYF DYVFTGVFTF EMVIKMIDQG
1160 1170 1180 1190 1200
LILQDGSYFR DLWNILDFVV VVGALVAFAL ANALGTNKGR DIKTIKSLRV
1210 1220 1230 1240 1250
LRVLRPLKTI KRLPKLKAVF DCVVTSLKNV FNILIVYKLF MFIFAVIAVQ
1260 1270 1280 1290 1300
LFKGKFFYCT DSSKDTEKEC IGNYVDHEKN KMEVKGREWK RHEFHYDNII
1310 1320 1330 1340 1350
WALLTLFTVS TGEGWPQVLQ HSVDVTEEDR GPSRSNRMEM SIFYVVYFVV
1360 1370 1380 1390 1400
FPFFFVNIFV ALIIITFQEQ GDKMMEECSL EKNERACIDF AISAKPLTRY
1410 1420 1430 1440 1450
MPQNRHTFQY RVWHFVVSPS FEYTIMAMIA LNTVVLMMKY YSAPCTYELA
1460 1470 1480 1490 1500
LKYLNIAFTM VFSLECVLKV IAFGFLNYFR DTWNIFDFIT VIGSITEIIL
1510 1520 1530 1540 1550
TDSKLVNTSG FNMSFLKLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY
1560 1570 1580 1590 1600
VCLLIAMLFF IYAIIGMQVF GNIKLDEESH INRHNNFRSF FGSLMLLFRS
1610 1620 1630 1640 1650
ATGEAWQEIM LSCLGEKGCE PDTTAPSGQN ESERCGTDLA YVYFVSFIFF
1660 1670 1680 1690 1700
CSFLMLNLFV AVIMDNFEYL TRDSSILGPH HLDEFVRVWA EYDRAACGRI
1710 1720 1730 1740 1750
HYTEMYEMLT LMSPPLGLGK RCPSKVAYKR LVLMNMPVAE DMTVHFTSTL
1760 1770 1780 1790 1800
MALIRTALDI KIAKGGADRQ QLDSELQKET LAIWPHLSQK MLDLLVPMPK
1810 1820 1830 1840 1850
ASDLTVGKIY AAMMIMDYYK QSKVKKQRQQ LEEQKNAPMF QRMEPSSLPQ
1860 1870 1880 1890 1900
EIIANAKALP YLQQDPVSGL SGRSGYPSMS PLSPQEIFQL ACMDPADDGQ
1910 1920 1930 1940 1950
FQEQQSLEPE VSELKSVQSS NHGIYLPPDT QEHAGSGRAS SMPRLTMDPQ
1960 1970 1980 1990 2000
VVTDPSSMRR SFSTIRDKRS NSSWLEEFSM ERSSENTYKS RRRSYHSSLR
2010 2020 2030 2040 2050
LSAHRLNSDS GHKSDTHRSG GRERGRSKER KHLLSPDVSR CNSEERGTQA
2060 2070 2080 2090 2100
DWESPERRQS RSPSEGRSQT PNRQGTGSLS ESSIPSISDT STPRRSRRQL
2110 2120 2130 2140 2150
PPVPPKPRPL LSYSSLMRHT GGISPPPDGS EGGSPLASQA LESNSACLTE
2160 2170 2180 2190 2200
SSNSLHPQQG QHPSPQHYIS EPYLALHEDS HASDCGEEET LTFEAAVATS
2210 2220 2230 2240 2250
LGRSNTIGSA PPLRHSWQMP NGHYRRRRRG GPGPGMMCGA VSDLLSDTEE
DDKC
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ61290 | CAC1E_MOUSE | Voltage-dependent R-type calcium ch... | Cacna1e Cach6, Cacnl1a6, Cchra1 | 2,272 | Annotation score: | ||
A0A087WS83 | A0A087WS83_MOUSE | Voltage-dependent R-type calcium ch... | Cacna1e | 2,273 | Annotation score: | ||
E9QK20 | E9QK20_MOUSE | Voltage-dependent R-type calcium ch... | Cacna1e | 1,965 | Annotation score: | ||
A0A571BF18 | A0A571BF18_MOUSE | Voltage-dependent R-type calcium ch... | Cacna1e | 585 | Annotation score: | ||
A0A2I3BPS0 | A0A2I3BPS0_MOUSE | Voltage-dependent R-type calcium ch... | Cacna1e | 110 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC099707 Genomic DNA No translation available. AC101727 Genomic DNA No translation available. AC112154 Genomic DNA No translation available. AC119156 Genomic DNA No translation available. AC122040 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000211821; ENSMUSP00000148507; ENSMUSG00000004110 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC099707 Genomic DNA No translation available. AC101727 Genomic DNA No translation available. AC112154 Genomic DNA No translation available. AC119156 Genomic DNA No translation available. AC122040 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 366012 |
Protocols and materials databases
Antibodypediai | 34433, 121 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000211821; ENSMUSP00000148507; ENSMUSG00000004110 |
Organism-specific databases
MGIi | MGI:106217, Cacna1e |
Phylogenomic databases
GeneTreei | ENSGT00940000155601 |
Miscellaneous databases
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR002048, EF_hand_dom IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005449, VDCC_R_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45628:SF5, PTHR45628:SF5, 1 hit |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01633, RVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1D5RLU3_MOUSE | |
Accessioni | A0A1D5RLU3Primary (citable) accession number: A0A1D5RLU3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2016 |
Last sequence update: | November 30, 2016 | |
Last modified: | April 7, 2021 | |
This is version 27 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |