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Protein
Submitted name:

Adenylate cyclase 5

Gene

ADCY5

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi476Magnesium 1; catalyticUniRule annotation1
Metal bindingi476Magnesium 2; catalyticUniRule annotation1
Metal bindingi477Magnesium 2; via carbonyl oxygen; catalyticUniRule annotation1
Metal bindingi520Magnesium 1; catalyticUniRule annotation1
Metal bindingi520Magnesium 2; catalyticUniRule annotation1
Binding sitei564ATPUniRule annotation1
Binding sitei1125ATPUniRule annotation1
Binding sitei1246ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi476 – 481ATPUniRule annotation6
Nucleotide bindingi518 – 520ATPUniRule annotation3
Nucleotide bindingi1199 – 1201ATPUniRule annotation3
Nucleotide bindingi1206 – 1210ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 5Imported
Gene namesi
Name:ADCY5Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 218HelicalSequence analysisAdd BLAST20
Transmembranei239 – 264HelicalSequence analysisAdd BLAST26
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei302 – 321HelicalSequence analysisAdd BLAST20
Transmembranei327 – 345HelicalSequence analysisAdd BLAST19
Transmembranei763 – 784HelicalSequence analysisAdd BLAST22
Transmembranei790 – 815HelicalSequence analysisAdd BLAST26
Transmembranei836 – 857HelicalSequence analysisAdd BLAST22
Transmembranei911 – 929HelicalSequence analysisAdd BLAST19
Transmembranei936 – 957HelicalSequence analysisAdd BLAST22
Transmembranei986 – 1005HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 598Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini1073 – 1212Guanylate cyclaseInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1024 – 1044Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119042
KOiK08045

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR032628 AC_N
IPR030672 Adcy
IPR009398 Adcy_conserved_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF16214 AC_N, 1 hit
PF06327 DUF1053, 1 hit
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF039050 Ade_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

A0A1D5RFY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSKSVSPP GYAAQKTAAP APRGGPEHRS AWGEADSRAN GYPHAPGGSA
60 70 80 90 100
RGSTKKPGGA VTPQQQQQQR LASRWRSDDD DDPPLSGDDP LAGGFGFSFR
110 120 130 140 150
SKSAWQERGG DDCGRGSRRQ RRGAAGGGST RAPPAGGGGG SAAAAASAGG
160 170 180 190 200
TEVRPRSVEV GLEERRGKGR AADELEAGAV EGGEESGDGG SSADSGSGAG
210 220 230 240 250
PGAVLSLGAC CLALLQIFRS KKFPSDKLER LYQRYFFRLN QSSLTMLMAV
260 270 280 290 300
LVLVCLVMLA FHAARPPLQL PYLAVLAAAV GVILIMAVLC NRAAFHQDHM
310 320 330 340 350
GLACYALIAV VLAVQVVGLL LPQPRSASEG IWWTVFFIYT IYTLLPVRMR
360 370 380 390 400
AAVLSGVLLS ALHLVIALRT NAQDQFLLKQ LVSNVLIFSC TNIVGVCTHY
410 420 430 440 450
PAEVSQRQAF QETRECIQAR LHSQRENQQQ ERLLLSVLPR HVAMEMKADI
460 470 480 490 500
NAKQEDMMFH KIYIQKHDNV SILFADIEGF TSLASQCTAQ ELVMTLNELF
510 520 530 540 550
ARFDKLAAEN HCLRIKILGD CYYCVSGLPE ARADHAHCCV EMGMDMIEAI
560 570 580 590 600
SLVREVTGVN VNMRVGIHSG RVHCGVLGLR KWQFDVWSND VTLANHMEAG
610 620 630 640 650
GKAGRIHITK ATLNYLNGDY EVEPGCGGER NAYLKEHSIE TFLILRCTQK
660 670 680 690 700
RKEEKAMIAK MNRQRTNSIG HNPPHWGAER PFYNHLGGNQ VSKEMKRMGF
710 720 730 740 750
EDPKDKNAQE SANPEDEVDE FLGRAIDARS IDRLRSEHVR KFLLTFREPD
760 770 780 790 800
LEKKYSKQVD DRFGAYVACA SLVFLFICFV QITIVPHSVF MLSFYLTCSL
810 820 830 840 850
LLTLVVFVSV IYSCVKLFPS PLQTLSRKIV RSKMNSTLVG VFTITLVFLA
860 870 880 890 900
AFVNMFTCNS KDLLGCLAQE HNISASQVNA CHVVESAVNY SLGDEQGFCG
910 920 930 940 950
SPWPNCNFPE YFTYSVLLSL LACSVFLQIN CIGKLALMLA IELIYVLIVE
960 970 980 990 1000
VPGVTLFDNA DLLVTANAID FFNNGTSQCP EHATKVALKV VTPIIISVFV
1010 1020 1030 1040 1050
LALYLHAQQV ESTARLDFLW KLQATEEKEE MEELQAYNRR LLHNILPKDV
1060 1070 1080 1090 1100
AAHFLARERR NDELYYQSCE CVAVMFASIA NFSEFYVELE ANNEGVECLR
1110 1120 1130 1140 1150
LLNEIIADFD EIISEDRFRQ LEKIKTIGST YMAASGLNDS TYDKVGKTHI
1160 1170 1180 1190 1200
KALADFAMKL MDQMKYINEH SFNNFQMKIG LNIGPVVAGV IGARKPQYDI
1210 1220 1230 1240 1250
WGNTVNVASR MDSTGVPDRI QVTTDMYQVL AANTYQLECR GVVKVKGKGE
1260
MMTYFLNGGP PLS
Length:1,263
Mass (Da):139,249
Last modified:November 30, 2016 - v1
Checksum:iF008E176F4E03407
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5QWQ7A0A1D5QWQ7_MACMU
Adenylate cyclase
ADCY5
1,259Annotation score:
F6W0C8F6W0C8_MACMU
Adenylate cyclase 5
ADCY5
903Annotation score:
F7H6A6F7H6A6_MACMU
Adenylate cyclase 5
ADCY5
887Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03023026 Genomic DNA No translation available.
JSUE03023027 Genomic DNA No translation available.
RefSeqiXP_014985498.1, XM_015130012.1
UniGeneiMmu.24273

Genome annotation databases

EnsembliENSMMUT00000070805; ENSMMUP00000059229; ENSMMUG00000002230
GeneIDi715897
KEGGimcc:715897

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03023026 Genomic DNA No translation available.
JSUE03023027 Genomic DNA No translation available.
RefSeqiXP_014985498.1, XM_015130012.1
UniGeneiMmu.24273

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000070805; ENSMMUP00000059229; ENSMMUG00000002230
GeneIDi715897
KEGGimcc:715897

Organism-specific databases

CTDi111

Phylogenomic databases

GeneTreeiENSGT00760000119042
KOiK08045

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR032628 AC_N
IPR030672 Adcy
IPR009398 Adcy_conserved_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF16214 AC_N, 1 hit
PF06327 DUF1053, 1 hit
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF039050 Ade_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1D5RFY5_MACMU
AccessioniPrimary (citable) accession number: A0A1D5RFY5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: September 12, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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