Angiotensin-converting enzyme

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bradykinin receptor binding Source: Ensembl
• carboxypeptidase activity Source: UniProtKB-KW
• chloride ion binding Source: Ensembl
• endopeptidase activity Source: Ensembl
• metallopeptidase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mitogen-activated protein kinase binding Source: Ensembl
• mitogen-activated protein kinase kinase binding Source: Ensembl
• peptidyl-dipeptidase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• tripeptidyl-peptidase activity Source: Ensembl
• zinc ion binding Source: Ensembl

GO - Biological processⁱ

• amyloid-beta metabolic process Source: Ensembl
• arachidonic acid secretion Source: Ensembl
• cell proliferation in bone marrow Source: Ensembl
• heart contraction Source: Ensembl
• hormone catabolic process Source: Ensembl
• kidney development Source: Ensembl
• negative regulation of gap junction assembly Source: Ensembl
• negative regulation of gene expression Source: Ensembl
• negative regulation of protein binding Source: Ensembl
• neutrophil mediated immunity Source: Ensembl
• peptide catabolic process Source: Ensembl
• positive regulation of peptidyl-cysteine S-nitrosylation Source: Ensembl
• positive regulation of peptidyl-tyrosine autophosphorylation Source: Ensembl
• positive regulation of protein binding Source: Ensembl
• positive regulation of protein tyrosine kinase activity Source: Ensembl
• positive regulation of systemic arterial blood pressure Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• posttranscriptional regulation of gene expression Source: Ensembl
• regulation of angiotensin metabolic process Source: Ensembl
• regulation of hematopoietic stem cell proliferation Source: Ensembl
• regulation of systemic arterial blood pressure by renin-angiotensin Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• bradykinin receptor binding Source: Ensembl
• mitogen-activated protein kinase binding Source: Ensembl
• mitogen-activated protein kinase kinase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGAASGRQGP GPLLQPLLLL LLLPPQPALA LDPGLQPGNF SADEAGAQLF 
        60         70         80         90        100
AQSYNSSAEQ VLFQSVAASW AHDTNITAEN ARRQEEAALL SQEFAEAWGQ 
       110        120        130        140        150
KAKELYEPIW QNFTDPELRK IIGAVGTLGS ANLPLAKRQQ YNALLSNMSR 
       160        170        180        190        200
IYSTAKVCLP NKTATCWSLD PDLTNILASS RSYAMLLFAW EGWHNAAGIP 
       210        220        230        240        250
LKPLYEDFTA LSNEAYKQDG FTDTGAYWRS WYNSPTFEDD LEHLYQQLEP 
       260        270        280        290        300
LYLNLHAFVR RALHRRYGDR YINLRGPIPA HLLGDMWAQS WENIYDMVVP 
       310        320        330        340        350
FPDKPNLDVT STMLQQGWNA THMFRVAEEF FTSLELSPMP PEFWEGSMLE 
       360        370        380        390        400
KPADGREVVC HASAWDFYNR KDFRIKQCTR VTMDQLSTVH HEMGHIQYYL 
       410        420        430        440        450
QYKDLPVSLR GGANPGFHEA IGDVLALSVS TPAHLHKIGL LDHVTNDTES 
       460        470        480        490        500
DINYLLKMAL EKIAFLPFGY LVDQWRWGVF NGRTPPSHYN FDWWYLRTKY 
       510        520        530        540        550
QGICPPVTRN ETHFDAGAKF HVPNVTPYIR YFVSFVLQFQ FHEALCKEAG 
       560        570        580        590        600
YEGPLHQCDI YQSTKAGAKL RKVLQAGSSR PWQEVLKDMV GSDALDAQPL 
       610        620        630        640        650
LNYFQPVTQW LQEQNRQNGE VLGWPEYQWR PPLPDNYPEG IDLVTDEAEA 
       660        670        680        690        700
SKFVEEYDRT SQVVWNEYAE ANWNYNTNIT TETSKILLQK NMQIANHTLK 
       710        720        730        740        750
YGTQARRFDV NHFQNTTIKR IIKKVQDLER AALPAQELEE YNKILLDMET 
       760        770        780        790        800
TYSVATVCHT NGSCLQLEPD LTNVMATSRK YEELLWAWEG WRDKAGRAIL 
       810        820        830        840        850
QFYPKYVELI NQAARLNGYV DAGDSWRSMY ETPSLEQDLE RLFQELQPLY 
       860        870        880        890        900
LNLHAYVRRA LHRHYGAQHI NLEGPIPAHL LGNMWAQTWS NIYDLVVPFP 
       910        920        930        940        950
SAPSMDPTEA MLKQGWTPRR MFKEADDFFT SLGLLPVPPE FWNKSMLEKP 
       960        970        980        990       1000
TDGREVVCHA SAWDFYNGKD FRIKQCTTVN LEDLVVAHHE MGHIQYFMQY 
      1010       1020       1030       1040       1050
KDLPVALREG ANPGFHEAIG DVLALSVSTP KHLHSLNLLS SEGGSHEHDI 
      1060       1070       1080       1090       1100
NFLMKMALDK IAFIPFSYLV DQWRWRVFDG SITKENYNQE WWSLRLKYQG 
      1110       1120       1130       1140       1150
LCPPVPRTQG DFDPGAKFHV PSSVPYIRYF ISFIIQFQFH EALCQAAGHT 
      1160       1170       1180       1190       1200
GPLHKCDIYQ SKEAGQRLAT AMKLGFSRPW PEAMQLITGQ PNMSASAMLS 
      1210       1220       1230       1240       1250
YFKPLLDWLR TENELHGEKL GWPQYNWTPN SARSEGPLPD SGRVSFLGLD 
      1260       1270       1280       1290       1300
LDAQQARVGQ WLLLFLGIAL LVATLGLSQR LFSIRHQSLH QHPQGPQFGS 

EVELRHS                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ