UniProtKB - A0A1D5R8J4 (A0A1D5R8J4_MACMU)
Protein
RING-type E3 ubiquitin transferase
Gene
RNF152
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- small GTPase binding Source: Ensembl
- ubiquitin protein ligase activity Source: GO_Central
GO - Biological processi
- apoptotic process Source: InterPro
- cellular response to amino acid starvation Source: GO_Central
- negative regulation of TORC1 signaling Source: Ensembl
- positive regulation of autophagy Source: GO_Central
- protein K48-linked ubiquitination Source: GO_Central
- protein K63-linked ubiquitination Source: Ensembl
Keywordsi
Molecular function | TransferaseARBA annotation |
Biological process | Ubl conjugation pathwayARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RNF152Imported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Lysosome
- Lysosome membrane ARBA annotation; Single-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass membrane protein ARBA annotation
Lysosome
- lysosomal membrane Source: GO_Central
Other locations
- integral component of organelle membrane Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 166 – 187 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
LysosomeARBA annotation, MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 55 | RING-typeInterPro annotationAdd BLAST | 44 |
Sequence similaritiesi
Belongs to the RNF152 family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00730000111317 |
OMAi | MSCVSKR |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR033609, RNF152 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR25464:SF1, PTHR25464:SF1, 1 hit |
Pfami | View protein in Pfam PF14634, zf-RING_5, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A1D5R8J4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR
60 70 80 90 100
CPWCRGVTKL PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY
110 120 130 140 150
MLPLPISKER ALLPGDMGCR LLPGSQQKSV TVVTIPAEQQ PLQGGAPQEA
160 170 180 190 200
AEEEQDRRGV VKSSTWSGVC TVILVACVLV FLLGIVLHNM SCISKRFTVI
SCG
Sequence databases
Genome annotation databases
Ensembli | ENSMMUT00000058927; ENSMMUP00000056634; ENSMMUG00000041998 ENSMMUT00000086396; ENSMMUP00000061333; ENSMMUG00000041998 |
GeneIDi | 699091 |
KEGGi | mcc:699091 |
Similar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSMMUT00000058927; ENSMMUP00000056634; ENSMMUG00000041998 ENSMMUT00000086396; ENSMMUP00000061333; ENSMMUG00000041998 |
GeneIDi | 699091 |
KEGGi | mcc:699091 |
Organism-specific databases
CTDi | 220441 |
Phylogenomic databases
GeneTreei | ENSGT00730000111317 |
OMAi | MSCVSKR |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Gene expression databases
ExpressionAtlasi | A0A1D5R8J4, baseline |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR033609, RNF152 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR25464:SF1, PTHR25464:SF1, 1 hit |
Pfami | View protein in Pfam PF14634, zf-RING_5, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1D5R8J4_MACMU | |
Accessioni | A0A1D5R8J4Primary (citable) accession number: A0A1D5R8J4 Secondary accession number(s): F6PLF8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 30, 2016 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 15 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |