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Protein

Sodium channel protein

Gene

SCN5A

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

  • voltage-gated ion channel activity Source: UniProtKB-KW
  • voltage-gated sodium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN5AImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 149HelicalUniRule annotationAdd BLAST23
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei230 – 247HelicalUniRule annotationAdd BLAST18
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei388 – 416HelicalUniRule annotationAdd BLAST29
Transmembranei718 – 736HelicalUniRule annotationAdd BLAST19
Transmembranei748 – 769HelicalUniRule annotationAdd BLAST22
Transmembranei781 – 798HelicalUniRule annotationAdd BLAST18
Transmembranei838 – 861HelicalUniRule annotationAdd BLAST24
Transmembranei881 – 902HelicalUniRule annotationAdd BLAST22
Transmembranei914 – 939HelicalUniRule annotationAdd BLAST26
Transmembranei1206 – 1225HelicalUniRule annotationAdd BLAST20
Transmembranei1246 – 1262HelicalUniRule annotationAdd BLAST17
Transmembranei1274 – 1295HelicalUniRule annotationAdd BLAST22
Transmembranei1323 – 1349HelicalUniRule annotationAdd BLAST27
Transmembranei1445 – 1471HelicalUniRule annotationAdd BLAST27
Transmembranei1530 – 1548HelicalUniRule annotationAdd BLAST19
Transmembranei1560 – 1582HelicalUniRule annotationAdd BLAST23
Transmembranei1594 – 1610HelicalUniRule annotationAdd BLAST17
Transmembranei1647 – 1675HelicalUniRule annotationAdd BLAST29
Transmembranei1750 – 1773HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiA0A1D5Q8U7 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 422Ion_transInterPro annotationAdd BLAST293
Domaini478 – 667Na_trans_cytoplInterPro annotationAdd BLAST190
Domaini718 – 943Ion_transInterPro annotationAdd BLAST226
Domaini953 – 1201Na_trans_assocInterPro annotationAdd BLAST249
Domaini1205 – 1480Ion_transInterPro annotationAdd BLAST276
Domaini1529 – 1783Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili413 – 451Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128242

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A1D5Q8U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLR ESREGLPEEE
60 70 80 90 100
APRPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK
110 120 130 140 150
TIFRFSATNA LYVLSPFHPI RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
210 220 230 240 250
IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGLV
310 320 330 340 350
WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH
360 370 380 390 400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI
460 470 480 490 500
RGVDTVSRSS LEMSPLAPVN SHERRSKRRK RMSSGTEECG EDRLPKSDSE
510 520 530 540 550
DGPRAMNHLS LTHGLSRTSV KPRSSRGSIF TFRRRDLGSE TDFADDENST
560 570 580 590 600
AGDSESHHTS LLVPWPLRRT SAQGQPSPGT STPGHALNGK KNSTVDCNGV
610 620 630 640 650
VSLLGAGDPE ATSPGSHLLR PVMLEHPPDT TTPSEEPGGP QMLTPQVPCI
660 670 680 690 700
DGFEEPGARQ RALSAVSVLT SALEELEESR RKCPPCWNRL AQRYLIWECC
710 720 730 740 750
PLWMSIKQGV KLVVMDPFAD LTITMCIVLN TLFMALEHYN MTSEFEEMLQ
760 770 780 790 800
VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG WNIFDSIIVI LSLMELGLSR
810 820 830 840 850
MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
860 870 880 890 900
FIFAVVGMQL FGKNYSELRD SDSGLLPRWH MMDFFHAFLI IFRILCGEWI
910 920 930 940 950
ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP
960 970 980 990 1000
DEDREMNNLQ LALARIQRGL RFVKRTTWDF CCGLLRQRPQ KPAALAAQGQ
1010 1020 1030 1040 1050
LPSCIATPYS APPPETEKVP PTRKETRFEE GEQPGQGTPR DPEPVCVPIA
1060 1070 1080 1090 1100
VAESDTDDQE EDEENSLDTE EESSKQQESQ PVSAGPEAPP DSRTWSQVSA
1110 1120 1130 1140 1150
TASSEAEASV SQADWQQQQR KEEPQAPGCG ETQEDSGSEG STADMTNTAE
1160 1170 1180 1190 1200
LLEQIPDLGQ DVKDPEDCFT EGCVRRCPCC AVDTSQAPGK VWWRLRKTCY
1210 1220 1230 1240 1250
HIVEHSWFET FIIFMILLSS GALAFEDIYL EERKTIKVLL EYADKMFTYV
1260 1270 1280 1290 1300
FVLEMLLKWV AYGFKKYFTN AWCWLDFLIV DVSLVSLVAN TLGFAEMGPI
1310 1320 1330 1340 1350
KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS
1360 1370 1380 1390 1400
IMGVNLFAGK FGRCINQTEG DLPLNYTIVN NKSQCESLNM TGELYWTKVK
1410 1420 1430 1440 1450
VNFDNVGAGY LALLQVATFK GWMDIMYAAV DSRGYEEQPQ WEYNLYMYIY
1460 1470 1480 1490 1500
FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK LGGQDIFMTE EQKKYYNAMK
1510 1520 1530 1540 1550
KLGSKKPQKP IPRPLNKYQG FIFDIVTKQA FDVTIMFLIC LNMVTMMVET
1560 1570 1580 1590 1600
DDQSPEKINI LAKINLLFVA IFTGECIVKL AALRHYYFTN SWNIFDFVVV
1610 1620 1630 1640 1650
ILSIVGTVLS DIIQKYFFSP TLFRVIRLAR IGRILRLIRG AKGIRTLLFA
1660 1670 1680 1690 1700
LMMSLPALFN IGLLLFLVMF IYSIFGMANF AYVKWEAGID DMFNFQTFAN
1710 1720 1730 1740 1750
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PTLPNSNGSR GDCGSPAVGI
1760 1770 1780 1790 1800
LFFTTYIIIS FLIVVNMYIA IILENFSVAT EESTEPLSED DFDMFYEIWE
1810 1820 1830 1840 1850
KFDPEATQFI EYSVLSDFAD ALSEPLRIAK PNQMSLINMD LPMVSGDRIH
1860 1870 1880 1890 1900
CMDILFAFTK RVLGESGEMD ALKIQMEEKF MAANPSKISY EPITTTLRRK
1910 1920 1930 1940 1950
HEEVSAMVIQ RAFRRHLLQR SVKHASFLFR QQTGSSLSEE DAPEREGLIA
1960 1970 1980 1990 2000
NVMNENFSRP FGPPSSSSIS STSFPPSYDS VTRATSDNIQ VPGSDYSHSE
2010
DVADFPPSPD RDRESIV
Length:2,017
Mass (Da):227,261
Last modified:November 30, 2016 - v1
Checksum:iB2CFEBEAEB44739B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CEN9F7CEN9_MACMU
Sodium channel protein
SCN5A
1,999Annotation score:
A0A1D5RFI4A0A1D5RFI4_MACMU
Sodium channel protein
SCN5A
2,017Annotation score:
A0A1D5QY66A0A1D5QY66_MACMU
Sodium channel protein
SCN5A
1,962Annotation score:
A0A1D5Q8T3A0A1D5Q8T3_MACMU
Uncharacterized protein
SCN5A
223Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03023977 Genomic DNA No translation available.
JSUE03023978 Genomic DNA No translation available.
RefSeqiXP_014986820.1, XM_015131334.1
UniGeneiMmu.29094

Genome annotation databases

EnsembliENSMMUT00000076751; ENSMMUP00000044465; ENSMMUG00000015825
GeneIDi695085

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03023977 Genomic DNA No translation available.
JSUE03023978 Genomic DNA No translation available.
RefSeqiXP_014986820.1, XM_015131334.1
UniGeneiMmu.29094

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000076751; ENSMMUP00000044465; ENSMMUG00000015825
GeneIDi695085

Organism-specific databases

CTDi6331

Phylogenomic databases

GeneTreeiENSGT00830000128242

Gene expression databases

ExpressionAtlasiA0A1D5Q8U7 baseline

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1D5Q8U7_MACMU
AccessioniPrimary (citable) accession number: A0A1D5Q8U7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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