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Entry version 20 (11 Dec 2019)
Sequence version 1 (30 Nov 2016)
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Protein

Fanconi anemia group M protein

Gene

FANCM

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity). This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi104 – 111ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi anemia group M protein (EC:3.6.4.13By similarity)
Short name:
Protein FACM
Alternative name(s):
ATP-dependent RNA helicase FANCM
Fanconi anemia-associated polypeptide of 250 kDa
Short name:
FAAP250
Protein Hef ortholog1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FANCM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi207D → A: Increased sister chromatid exchanges. No effect on FANCD2 monoubiquitination, nor on cisplatin sensitivity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004392481 – 2041Fanconi anemia group M proteinAdd BLAST2041

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; hyperphosphorylated in response to genotoxic stress.1 Publication

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Fanconi anemia (FA) core complex. The FA core complex associates with Bloom syndrome (BLM) complex. This supercomplex between FA and BLM complexes has been called BRAFT.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000020332

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 259Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini447 – 631Helicase C-terminalPROSITE-ProRule annotationAdd BLAST185

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi207 – 210DEAH boxPROSITE-ProRule annotation4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K10896

Database of Orthologous Groups

More...
OrthoDBi
989616at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006166 ERCC4_domain
IPR031879 FANCM-MHF-bd
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02732 ERCC4, 1 hit
PF16783 FANCM-MHF_bd, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00891 ERCC4, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781 SSF47781, 1 hit
SSF52540 SSF52540, 1 hit
SSF52980 SSF52980, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1D5PRR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGRQRTLP EAWRRAAGPA LQAGRDADGN DDDDDELLAA AAAELDPDPN
60 70 80 90 100
PNVDPNPGPG PEAAAGGFCA AAGALWIYPT NRPERPYQLR MARAALFANT
110 120 130 140 150
LLCLPTGLGK TFVAAVVMYN FYRWFPSGKV LFLAPTKALV AQQMEACAQL
160 170 180 190 200
MGIPGRDMAE MTGGTQALSR RELWASRRVF FLTPQIMVND LSRGTCPAVE
210 220 230 240 250
VKCLVVDEAH KALGNHAYCQ VVKELSRYTT QFRVLALTAT PGSDTKAVQQ
260 270 280 290 300
VVSNLLIAQI ELCSEDSPEI QPYSHERQVE KIVVPLGEEL GGIQRAYIHV
310 320 330 340 350
LETFAGRLIK LGVLARRDVP SLTKYQIILA RDQYRKNPSP QNVGMQPGII
360 370 380 390 400
EGDFALCISL YHGYELLQQM GVRSLFIYLC GIMDGSKGLT RTKNELGRNE
410 420 430 440 450
DFMRLYQQLT DMFSDTCQTS ANGNLHKSRT VSENKKEFIY SHPKLKKLEE
460 470 480 490 500
IVIEHFKSRK MGCSDQTTSG GTCVDTRVMI FSSFRDSVQE IAEMLSRFSP
510 520 530 540 550
VVRVMTFVGH STGKSTKGFT QKEQLEVVKR FREGGYNTLV STCVGEEGLD
560 570 580 590 600
IGEVDLIICF DAQKSPIRLV QRMGRTGRQR QGRVVVILAE GREERTYNQS
610 620 630 640 650
QSNRRSIQKA ISGNKMLHFY QHSPRMIPEG INPELHRMFI TAEKYKPNDS
660 670 680 690 700
GRLPKGRPSS LHHKSALFSC VTDPKEMHCH ENWSLSPEEF EIWDRLYRLK
710 720 730 740 750
ENDGVKEPIL PHTRFETLEN LDKTSKPEEE AAHKLSLSEW SIWQSRPFPT
760 770 780 790 800
SMVDHSDRCY HFISVMELIE VMRQEQGDCS YELELQPHLR IEDIHVRRNK
810 820 830 840 850
GHLSTTSSAF AQKTHSSKRD MARTKRPFVP DVNDNEREFF SIFKTTNTKT
860 870 880 890 900
PRTAPGLDLE EPELPTDTNG SEPCSARRLT LVASTDQGSP KEEEIEKVTF
910 920 930 940 950
DLNEFNDLCD DGESTVAHES AAVKDLRLLD KHCSSVGLNH TDLGYSSFTA
960 970 980 990 1000
EKSPASSDLF YLPESHVDSF VLVSSSAELA GLEGAFSCVK GLLAHSPPPV
1010 1020 1030 1040 1050
SKLEGIEELL RHEETLCPLP KVSCRSYSGQ LPHGDFPSSL AVDQSLLPAE
1060 1070 1080 1090 1100
SPELEVTIGL SAAVNTCVSK PASTPTAAGG AEERPPGGGS FHSLLGKEGF
1110 1120 1130 1140 1150
TANHTDNPPN KHFVQGDEED SEMKRDVTID GEKSIHLFED EHTYKVNDEM
1160 1170 1180 1190 1200
PSVDVEPLLR LGSGGHTARP SAGPASQQPP SGDSPRGDTA CGEGAARGEM
1210 1220 1230 1240 1250
APGGAWGRGS AAEQALHNSE LCDYSQELFS VNFDLGFSIE ECEEEIFEGD
1260 1270 1280 1290 1300
TDAMNTPKLN SASRSRADVQ LTANRKSLND GCRVQTPPKW DCKGLKGRNI
1310 1320 1330 1340 1350
STPLPLQSGH VRDTAVPGGT AGGRTGRGSP GASPPSPATP TGRRVSSAEA
1360 1370 1380 1390 1400
TRRIRKKVFS TVREETPEVC PTDKVNPNSQ RNSFGSSASD ALHTTGGRTE
1410 1420 1430 1440 1450
NLEGTNLHTS RVFPAEGTSS ESEEEIVFQR KNRRNNVLRS PDVGSDSDFG
1460 1470 1480 1490 1500
SPVCAVRKRR HPLTVSDVSS DDGVDFHKNP NRGTRGCSAA GSKAQLRGVK
1510 1520 1530 1540 1550
RQKVRSKVTC KNAARQFLDE EAELSQQDES CVSSDETEDT DKELSSSLAQ
1560 1570 1580 1590 1600
FLNDDAEVTQ VLNDSEMRGV YLKSVRSPAL GSRYRMVHRE FNSTEIFSQI
1610 1620 1630 1640 1650
PEQDEAYAED SFCVAEGDEE TCNKSESSEE EEVCVNFDLL NNESFGGGGG
1660 1670 1680 1690 1700
RYLTRRRKKL HGANMEQNCS APVQKKPSRI IVLSDSSGEE TNVSNEKGTA
1710 1720 1730 1740 1750
AHCSRAGREN AELLTSMPSV SSVPHKKSAG DVSAHQSAES KSGMLLGLKA
1760 1770 1780 1790 1800
SVSEVLDFHP GPRSGSGKEA LQAAAQHLQL ESSVKNSAGN APGATKASPA
1810 1820 1830 1840 1850
LLDGDTALCV LVDSREISSG ADVISSLKAV HGLKVQVCSL GSGDYVVSNR
1860 1870 1880 1890 1900
MAVERKFQSE LLSSVNRTKV TQRLQRLQGM FERVCVIVEK DRTRPGETSR
1910 1920 1930 1940 1950
FSQRTQHYDA TLAALLQAGI RVLFSSCQEE TAVLLKELAL LEQRKNAAIC
1960 1970 1980 1990 2000
VPTEVEGHKQ EMLNFYLSLP NISYLAALNM CHHFSSVRTM VNSSPSDIAA
2010 2020 2030 2040
GARVSLQRAE ETYRYLRYGF DTQMLPESLC AKGKSNTATR S
Length:2,041
Mass (Da):224,006
Last modified:November 30, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i691CC9D89A35486D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN04000285 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_015132266.1, XM_015276780.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100857997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:100857997

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000285 Genomic DNA No translation available.
RefSeqiXP_015132266.1, XM_015276780.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020332

Genome annotation databases

GeneIDi100857997
KEGGigga:100857997

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57697

Phylogenomic databases

KOiK10896
OrthoDBi989616at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A0A1D5PRR9

Family and domain databases

InterProiView protein in InterPro
IPR006166 ERCC4_domain
IPR031879 FANCM-MHF-bd
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like
PfamiView protein in Pfam
PF02732 ERCC4, 1 hit
PF16783 FANCM-MHF_bd, 1 hit
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00891 ERCC4, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52540 SSF52540, 1 hit
SSF52980 SSF52980, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFANCM_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D5PRR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: November 30, 2016
Last modified: December 11, 2019
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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