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Protein

DNA primase

Gene

PRIM1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processDNA replicationUniRule annotation, Transcription

Enzyme and pathway databases

ReactomeiR-GGA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-GGA-174411 Polymerase switching on the C-strand of the telomere
R-GGA-174430 Telomere C-strand synthesis initiation
R-GGA-68952 DNA replication initiation
R-GGA-68962 Activation of the pre-replicative complex
R-GGA-69091 Polymerase switching
R-GGA-69166 Removal of the Flap Intermediate
R-GGA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primaseUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic-type primase small subunit family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000011466
    KOiK02684

    Family and domain databases

    CDDicd04860 AE_Prim_S, 1 hit
    InterProiView protein in InterPro
    IPR002755 DNA_primase_S
    IPR014052 DNA_primase_ssu_euk/arc
    PANTHERiPTHR10536 PTHR10536, 1 hit
    PfamiView protein in Pfam
    PF01896 DNA_primase_S, 1 hit
    TIGRFAMsiTIGR00335 primase_sml, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    A0A1D5PGK7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAPFEPAALP ELLPVFYRRL FPHGAYGRWL GYGGVEKNYF QLREFSFTLR
    60 70 80 90 100
    DDVYVRFQSF GSPQELEKEL QRTNPYKIDI GAVYSHRPNQ HNTVHLGAFQ
    110 120 130 140 150
    PVEKELVFDI DMTDYDDVRT CCSSADICSK CWTLMTIAVR VIDRALVEDL
    160 170 180 190 200
    GMKHRLWVYS GRRGVHCWVC DDAVRKWSPA LRAAAVEYLS LVKGGAETVK
    210 220 230 240 250
    KVNLSEPVHP FIRRSVSVVE KYFEAYALQG QDILGSPERW DKVLALVPEE
    260 270 280 290 300
    HRELLQSEFP KKRDSVQRWE LLKGRMERTR RLASSGKGTA CYADWEVMLQ
    310 320 330 340 350
    YCFPRLDINV SKGIGHLLKS PFSVHPKTGR ISVPLDVQRL DDFDPFAVPT
    360 370 380 390 400
    ISSLCQELDA AGDDAEQEDG EETEPKRRMR DYRRTQLAPY VKAFEQFVEE
    410
    MERGRRMERL RRSDLQGEF
    Length:419
    Mass (Da):48,498
    Last modified:November 30, 2016 - v1
    Checksum:i5147A18FF863EEEC
    GO

    Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A1L1RQZ9A0A1L1RQZ9_CHICK
    DNA primase
    PRIM1
    386Annotation score:
    A0A1D5P6I0A0A1D5P6I0_CHICK
    DNA primase
    PRIM1
    394Annotation score:
    A0A1D5P0T5A0A1D5P0T5_CHICK
    DNA primase
    PRIM1
    431Annotation score:
    A0A1D5PT40A0A1D5PT40_CHICK
    DNA primase
    PRIM1
    415Annotation score:

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AADN04000730 Genomic DNA No translation available.
    RefSeqiXP_015155882.1, XM_015300396.1

    Genome annotation databases

    EnsembliENSGALT00000078729; ENSGALP00000051930; ENSGALG00000041973
    GeneIDi426646
    KEGGigga:426646

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AADN04000730 Genomic DNA No translation available.
    RefSeqiXP_015155882.1, XM_015300396.1

    3D structure databases

    ModBaseiSearch...
    MobiDBiSearch...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSGALT00000078729; ENSGALP00000051930; ENSGALG00000041973
    GeneIDi426646
    KEGGigga:426646

    Organism-specific databases

    CTDi5557

    Phylogenomic databases

    GeneTreeiENSGT00390000011466
    KOiK02684

    Enzyme and pathway databases

    ReactomeiR-GGA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
    R-GGA-174411 Polymerase switching on the C-strand of the telomere
    R-GGA-174430 Telomere C-strand synthesis initiation
    R-GGA-68952 DNA replication initiation
    R-GGA-68962 Activation of the pre-replicative complex
    R-GGA-69091 Polymerase switching
    R-GGA-69166 Removal of the Flap Intermediate
    R-GGA-69183 Processive synthesis on the lagging strand

    Family and domain databases

    CDDicd04860 AE_Prim_S, 1 hit
    InterProiView protein in InterPro
    IPR002755 DNA_primase_S
    IPR014052 DNA_primase_ssu_euk/arc
    PANTHERiPTHR10536 PTHR10536, 1 hit
    PfamiView protein in Pfam
    PF01896 DNA_primase_S, 1 hit
    TIGRFAMsiTIGR00335 primase_sml, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiA0A1D5PGK7_CHICK
    AccessioniPrimary (citable) accession number: A0A1D5PGK7
    Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
    Last sequence update: November 30, 2016
    Last modified: September 12, 2018
    This is version 11 of the entry and version 1 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported
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    Main funding by: National Institutes of Health

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