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Entry version 26 (29 Sep 2021)
Sequence version 1 (30 Nov 2016)
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Protein

Hepatocyte growth factor

Gene

HGF

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factorUniRule annotationARBA annotation, Serine protease homologUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-114608, Platelet degranulation
R-GGA-1257604, PIP3 activates AKT signaling
R-GGA-5673001, RAF/MAP kinase cascade
R-GGA-6806942, MET Receptor Activation
R-GGA-6807004, Negative regulation of MET activity
R-GGA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-GGA-8851805, MET activates RAS signaling
R-GGA-8851907, MET activates PI3K/AKT signaling
R-GGA-8865999, MET activates PTPN11
R-GGA-8874081, MET activates PTK2 signaling
R-GGA-8875513, MET interacts with TNS proteins
R-GGA-8875555, MET activates RAP1 and RAC1
R-GGA-8875656, MET receptor recycling
R-GGA-8875791, MET activates STAT3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatocyte growth factorUniRule annotationARBA annotation
Alternative name(s):
Hepatopoietin-AUniRule annotation
Scatter factorUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HGFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500892729928 – 726Hepatocyte growth factorSequence analysisAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi207 ↔ 284PROSITE-ProRule annotation
Disulfide bondi228 ↔ 267PROSITE-ProRule annotation
Disulfide bondi256 ↔ 279PROSITE-ProRule annotation
Disulfide bondi322 ↔ 361PROSITE-ProRule annotation
Disulfide bondi350 ↔ 373PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, Pyrrolidone carboxylic acidARBA annotation, ZymogenARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A1D5PAR6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond.

UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000039002

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1D5PAR6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 119AppleInterPro annotationAdd BLAST87
Domaini123 – 202KringleInterPro annotationAdd BLAST80
Domaini206 – 284KringleInterPro annotationAdd BLAST79
Domaini300 – 379KringleInterPro annotationAdd BLAST80
Domaini386 – 467KringleInterPro annotationAdd BLAST82
Domaini493 – 721Peptidase S1InterPro annotationAdd BLAST229

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR40, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156019

Identification of Orthologs from Complete Genome Data

More...
OMAi
TNIPQCG

Database of Orthologous Groups

More...
OrthoDBi
164039at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00108, KR, 4 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
2.40.20.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027284, Hepatocyte_GF
IPR024174, HGF/MST1
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR003609, Pan_app
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00051, Kringle, 4 hits
PF00024, PAN_1, 1 hit
PF00089, Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500183, Hepatocyte_GF, 1 hit
PIRSF001152, HGF_MST1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00130, KR, 4 hits
SM00473, PAN_AP, 1 hit
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF57440, SSF57440, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00021, KRINGLE_1, 4 hits
PS50070, KRINGLE_2, 4 hits
PS50948, PAN, 1 hit
PS50240, TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A1D5PAR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWATQLLPAL LLHQLLLPPI TIPAAEGKGK RRNPLHDYKK TGELMLIKVN
60 70 80 90 100
KTLEVKTKLL NTTEQCAKRC SRNKGLSFTC KAFAYDRVTK RCHWLSFNSL
110 120 130 140 150
TNGVRKKQDH AFDLFEKKDY VRNCIIGKGA EYKGTISITK SGIQCQAWNS
160 170 180 190 200
MIPHEHSFLP SSYRGKDLRE NYCRNPRGEE GGPWCFTTSP QMRHEVCDIP
210 220 230 240 250
LCSEVECMTC NGESYRGPMD HTESGKECQR WDLQRPHKHK FRPERYPDKG
260 270 280 290 300
FDDNYCRNPD GKLRPWCYTL DPNTPWEFCA IKTCDVGILN STEAVAETTT
310 320 330 340 350
CIQGQGEGYR GTVNTIWSGI QCQRWDSQFP HQHNITPENF KCKDLRENYC
360 370 380 390 400
RNPDGSESPW CFTTDPNIRI GYCSQIPKCD VSNEQDCYRG NGKSYMGNLS
410 420 430 440 450
KTRFGLTCST WDKNIEDLRR HIQIFREPDV SKLKKNYCRN PDDDFHGPWC
460 470 480 490 500
YTDDPLIPWD YCPISRCTGD TTPTTTSLDD TVIPCASTKH LRVVNGIPTQ
510 520 530 540 550
TNEGWVVSLT YRNKHICGGT LVKEEWVLTA RQCFPSRYKD LKDYKAWLGV
560 570 580 590 600
HNIKGKGEEK HRQVRNISQL VYGPAGSDLV LLKLSRPAIL TNFVEIIRLP
610 620 630 640 650
ISGCTIPEKT SCSVFGWGYT GLPNYDGLLR VANLFILGNE KCNQYLKGKI
660 670 680 690 700
TVNESEICAV AETIGAGPCE RDYGGPLVCE QNRLKIVVGV IVPGRGCAIR
710 720
NRPGIFVRVS YYSRWIHKIM MTYRKP
Length:726
Mass (Da):82,900
Last modified:November 30, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5816487E7CBC0DD7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2U5D1A0A3Q2U5D1_CHICK
Hepatocyte growth factor
HGF
682Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000100 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001025541.2, NM_001030370.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000078551; ENSGALP00000049829; ENSGALG00000033974

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395941

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395941

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000100 Genomic DNA No translation available.
RefSeqiNP_001025541.2, NM_001030370.3

3D structure databases

SMRiA0A1D5PAR6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039002

Genome annotation databases

EnsembliENSGALT00000078551; ENSGALP00000049829; ENSGALG00000033974
GeneIDi395941
KEGGigga:395941

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3082

Phylogenomic databases

eggNOGiENOG502QR40, Eukaryota
GeneTreeiENSGT00940000156019
OMAiTNIPQCG
OrthoDBi164039at2759

Enzyme and pathway databases

ReactomeiR-GGA-114608, Platelet degranulation
R-GGA-1257604, PIP3 activates AKT signaling
R-GGA-5673001, RAF/MAP kinase cascade
R-GGA-6806942, MET Receptor Activation
R-GGA-6807004, Negative regulation of MET activity
R-GGA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-GGA-8851805, MET activates RAS signaling
R-GGA-8851907, MET activates PI3K/AKT signaling
R-GGA-8865999, MET activates PTPN11
R-GGA-8874081, MET activates PTK2 signaling
R-GGA-8875513, MET interacts with TNS proteins
R-GGA-8875555, MET activates RAP1 and RAC1
R-GGA-8875656, MET receptor recycling
R-GGA-8875791, MET activates STAT3

Gene expression databases

ExpressionAtlasiA0A1D5PAR6, baseline and differential

Family and domain databases

CDDicd00108, KR, 4 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR027284, Hepatocyte_GF
IPR024174, HGF/MST1
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR003609, Pan_app
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom
PfamiView protein in Pfam
PF00051, Kringle, 4 hits
PF00024, PAN_1, 1 hit
PF00089, Trypsin, 1 hit
PIRSFiPIRSF500183, Hepatocyte_GF, 1 hit
PIRSF001152, HGF_MST1, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130, KR, 4 hits
SM00473, PAN_AP, 1 hit
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF57440, SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021, KRINGLE_1, 4 hits
PS50070, KRINGLE_2, 4 hits
PS50948, PAN, 1 hit
PS50240, TRYPSIN_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1D5PAR6_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D5PAR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: September 29, 2021
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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