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Entry version 19 (16 Jan 2019)
Sequence version 2 (15 Feb 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

COL4A1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-1442490 Collagen degradation
R-GGA-1474244 Extracellular matrix organization
R-GGA-1650814 Collagen biosynthesis and modifying enzymes
R-GGA-186797 Signaling by PDGF
R-GGA-2022090 Assembly of collagen fibrils and other multimeric structures
R-GGA-216083 Integrin cell surface interactions
R-GGA-2243919 Crosslinking of collagen fibrils
R-GGA-3000157 Laminin interactions
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-419037 NCAM1 interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL4A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500984154021 – 1669Sequence analysisAdd BLAST1649

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1445 – 1669Collagen IV NC1InterPro annotationAdd BLAST225

Keywords - Domaini

CollagenSAAS annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157678

KEGG Orthology (KO)

More...
KOi
K06237

Database of Orthologous Groups

More...
OrthoDBi
63831at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1D5P8P3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRWLGFGLL LSAELSAVSA AGCSGCGKCD CSGVKGQKGE RGLPGLQGVI
60 70 80 90 100
GFPGMQGPEG PPGPPGLKGD TGEPGLPGTK GTRGPPGPSG FPGNPGLPGI
110 120 130 140 150
PGQDGPPGPP GIPGCNGTKG ERGPVGPPGL PGLTGSIGPP GPPGIKGDPG
160 170 180 190 200
EVIGILPPSV LKGDKGFPGQ PGLPGPPGTP GFQGPMGPPG IPGEPGPPGP
210 220 230 240 250
PGPPGEKGYM GLGFQGPKGE KGEQGVQGPP GPPGPAPHMK EKGSEIIKGE
260 270 280 290 300
KGEPGEKGEQ GVPGLPGSGY RGEKGEPGKP GPRGKPGKDG EPGPKGEPGL
310 320 330 340 350
PGGFGIPGRP GEPGAKGEKG DQGPQGPPGR IIDAGPIDTF GEKGDPGVSG
360 370 380 390 400
LPGLKGQKGE KGFPGAQGIP GIPGRPVPDM VGSPGVPGQR GEKGEKGSPG
410 420 430 440 450
FPIPGPPGRD GFPGPPGLPG PPGPPGVTDG IDQCQQGQPG APGVPGPPGQ
460 470 480 490 500
HGFPGEMGEK GEKGETCALC DKVGPPGLPG PQGLPGPAGF PGQSGFKGDR
510 520 530 540 550
GLPGLDGLPG VPGPPGAPGL IGLPGAKGEP GDFTYDSILK GEKGDPGFPG
560 570 580 590 600
QPGIPGREGT PGKDGLPGPQ GPKGASGTAG LKGERGPPGQ PGFPGVRGER
610 620 630 640 650
GLPGSPGVGT AGLPGDKGER GFAGTPGLPG LPGTKGEAGR TVPLPGPPGA
660 670 680 690 700
DGLPGPPGFP GPQGDKGNPG LPGRPGLPGE KGAVGQPGIG FPGPPGPKGF
710 720 730 740 750
PGQPGSPGPP GTPGTPGLDG FPGTPGLQGQ KGEPGVGLPG PKGLPGIPGP
760 770 780 790 800
AGIPGEKGNP GLPGLRGEQG FPGVPGQQGF RGDPGLPGLQ GLPGPQGSPG
810 820 830 840 850
VGPPGLPGPA GQPGPEGPPG FPGIKGERGF PGIPGLDMPG PKGDKGSQGQ
860 870 880 890 900
PGVPGSVGLP GLPGPQGSVG LKGSAGAKGE MGVMGTPGLP GTPGPVGDRG
910 920 930 940 950
LPGEKGSQGL KGVVGPQGEP GVKGDKGEAG LPGIPGSMDT MDMVSLKGQK
960 970 980 990 1000
GDPGEKGDLG PTGEKGLRGE YGEPGIPGRD GEPGTPGQPG PKGDQGPPGY
1010 1020 1030 1040 1050
PGDPGIPGQK GSVGEMGLPG TPGEKGLPGI PGSPGTPGFP GQKGEKGDKG
1060 1070 1080 1090 1100
AAGFPGIGFP GSPGEKGEPG RTGSPGLSGD KGEKGNAGIP GMPGAPGPKG
1110 1120 1130 1140 1150
SPGIAGFPGN PGLHGAKGEK GLPGLSGIPG LKGEPGEPGV PGPAGSIGQK
1160 1170 1180 1190 1200
GEPGYDGIPG TAGAKGEQGV PGRGVPGYPG AKGDKGAKGE VGFPGSPGIP
1210 1220 1230 1240 1250
GIPGLKGEQG YAGPPGPKGN QGLPGLPGSA IEGPKGDRGP QGQPGLPGLP
1260 1270 1280 1290 1300
GPTGPPGPPG LKGAKGEQGS DGWPGTPGGP GDKGDPGFQG LPGSPGLPGG
1310 1320 1330 1340 1350
AGEKGDLGPP GVPGVPGPKG SAGFPGLKGE RGDQGLPGSK GLQGPPGPPG
1360 1370 1380 1390 1400
AFQLIKGDPG LPGPVGPVGL KGFPGHPGPK GQQGVTGPSG VPGPPGSPGF
1410 1420 1430 1440 1450
DGRPGQKGEV GPYGPPGPRG IPGPPGPEGL PGAMGPPGAA SVAHGFLVTR
1460 1470 1480 1490 1500
HSQTTEEPQC PFGTRLIYHG YSLLYVQGNE RAHGQDLGTA GSCLRKFSTM
1510 1520 1530 1540 1550
PFLFCNINNV CNFASRNDYS YWLSTPEPMP MSMAPITGES IRPFISRCSV
1560 1570 1580 1590 1600
CEAPAMVIAV HSQTIQIPPC PEGWSSLWIG YSFVMHTSAG AEGSGQALAS
1610 1620 1630 1640 1650
PGSCLEEFRS APFIECHGRG TCNYYANAYS FWLATIERNE MFKKPTPSTL
1660
KAGDLRSNVS RCQVCMRNT
Length:1,669
Mass (Da):160,770
Last modified:February 15, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFFE11D5996FC6BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN04000282 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001155871.1, NM_001162399.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.20359
Gga.4258

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000053661; ENSGALP00000049092; ENSGALG00000036798

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395530

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000282 Genomic DNA No translation available.
RefSeqiNP_001155871.1, NM_001162399.2
UniGeneiGga.20359
Gga.4258

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000053661; ENSGALP00000049092; ENSGALG00000036798
GeneIDi395530
KEGGigga:395530

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1282

Phylogenomic databases

GeneTreeiENSGT00940000157678
KOiK06237
OrthoDBi63831at2759

Enzyme and pathway databases

ReactomeiR-GGA-1442490 Collagen degradation
R-GGA-1474244 Extracellular matrix organization
R-GGA-1650814 Collagen biosynthesis and modifying enzymes
R-GGA-186797 Signaling by PDGF
R-GGA-2022090 Assembly of collagen fibrils and other multimeric structures
R-GGA-216083 Integrin cell surface interactions
R-GGA-2243919 Crosslinking of collagen fibrils
R-GGA-3000157 Laminin interactions
R-GGA-3000171 Non-integrin membrane-ECM interactions
R-GGA-419037 NCAM1 interactions

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 17 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1D5P8P3_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D5P8P3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: February 15, 2017
Last modified: January 16, 2019
This is version 19 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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