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Protein

Proteasome subunit beta

Gene

psmB

Organism
Methanobacterium congolense
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotationSAAS annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotationSAAS annotation

Activity regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunitUniRule annotation
Proteasome core protein PsmBUniRule annotation
Gene namesi
Name:psmBUniRule annotationImported
ORF Names:MCBB_2034Imported
OrganismiMethanobacterium congolenseImported
Taxonomic identifieri118062 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium
Proteomesi
  • UP000094707 Componenti: Chromosome i

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation, ProteasomeUniRule annotationSAAS annotationImported

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_50090064161 – 9Removed in mature form; by autocatalysisUniRule annotation9

Keywords - PTMi

Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK03433

Family and domain databases

CDDicd03764 proteasome_beta_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_02113_A Proteasome_B_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR019983 Pept_T1A_Psome_bsu_arc
IPR000243 Pept_T1A_subB
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03634 arc_protsome_B, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1D3L4L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDKNQLIGT TTVGLTCKDG VVFATERRAT MGNLVAHKVA EKIFRIDDHI
60 70 80 90 100
GATIAGSVSH AQVLMKYISA EVALYRLRNG ARISVDSAAT LTSNILHSNP
110 120 130 140 150
LYVQTLLGGV DAKGPAIYSL DPAGGVVKDM VVSTGSGSPF AYGVLEDRYS
160 170 180 190 200
EDLYVEEGVD VAIKAIKSAI ERDTYSGNGM LVATITEEEG FKMLPPEEVE

KKIKELN
Length:207
Mass (Da):22,194
Last modified:November 30, 2016 - v1
Checksum:i99B58E2887EBB177
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT607756 Genomic DNA Translation: SCG86582.1
RefSeqiWP_071907632.1, NZ_LT607756.1

Genome annotation databases

EnsemblBacteriaiSCG86582; SCG86582; MCBB_2034
GeneIDi30412869
KEGGimcub:MCBB_2034
PATRICifig|129848.4.peg.2083

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT607756 Genomic DNA Translation: SCG86582.1
RefSeqiWP_071907632.1, NZ_LT607756.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiSCG86582; SCG86582; MCBB_2034
GeneIDi30412869
KEGGimcub:MCBB_2034
PATRICifig|129848.4.peg.2083

Phylogenomic databases

KOiK03433

Family and domain databases

CDDicd03764 proteasome_beta_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_02113_A Proteasome_B_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR019983 Pept_T1A_Psome_bsu_arc
IPR000243 Pept_T1A_subB
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03634 arc_protsome_B, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1D3L4L5_9EURY
AccessioniPrimary (citable) accession number: A0A1D3L4L5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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