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Protein

DNA ligase

Gene

lig

Organism
Methanobrevibacter sp. A54
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei246ATPUniRule annotation1
Active sitei248N6-AMP-lysine intermediateUniRule annotation1
Binding sitei253ATPUniRule annotation1
Binding sitei268ATPUniRule annotation1
Binding sitei298ATPUniRule annotation1
Binding sitei337ATPUniRule annotation1
Binding sitei414ATPUniRule annotation1
Binding sitei420ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
ORF Names:A9757_03265Imported
OrganismiMethanobrevibacter sp. A54Imported
Taxonomic identifieri1860156 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000094499 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A1D2WUQ9
SMRiA0A1D2WUQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 455DNA_LIGASE_A3InterPro annotationAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili3 – 23Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1D2WUQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYQELVDVY SALENTTKRL EKTQIISNFL LKLDSTTLEQ VGLLILGSIF
60 70 80 90 100
PAWSDKEIGI GNKLVMQAVG EAVGVTPDKV EDAVRDQGDI GLACISLYAK
110 120 130 140 150
KSQTTFFSQP LTIDFVFKSL RKLSEKSGAR STKRKIDIIL EMLSQASASE
160 170 180 190 200
AKYLTRTILE ELRIGVGEGV VRDAIAQAFN IDKSVVERAM MLTNDLGLIA
210 220 230 240 250
VVAKEKGEGG LKELNLTPGT PVKPMLAQLA PPIPEIINEM GVAICETKYD
260 270 280 290 300
GIRLQVHRHS DEIKIFTRRL ENITHALPEI VDLFNEYLPH EDYIVEGEVI
310 320 330 340 350
ATRDGNPLSF QNILHRVRRK HNIDEAMEQV PLKVFLFDLL YYIVPMIDEP
360 370 380 390 400
LLKRRKKLEE IVNTTPDEIN LSNMVYGTPD TIKEVEDLFE LSIAQHHEGI
410 420 430 440 450
MIKDAGEPYI PGLRGKKMLK YKAEPETLDM VVVGGTYGIG KRGDFVGSYL
460 470 480 490 500
VSLRDEDNNL KTVAYVATGL DDATLEYLTK KMKEYELSTK GREIVVEPKI
510 520 530 540 550
VLEVAFSEIV ESPEYETGYS LRFPVVKNIR KDKGVDDIDT VERLISMYET

Q
Length:551
Mass (Da):61,948
Last modified:November 30, 2016 - v1
Checksum:i5CB10B16F770ACFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MAIE01000046 Genomic DNA Translation: OED05139.1
RefSeqiWP_004036507.1, NZ_MAIE01000046.1

Genome annotation databases

EnsemblBacteriaiOED05139; OED05139; A9757_03265
GeneIDi5216232

Similar proteinsi

Entry informationi

Entry nameiA0A1D2WUQ9_9EURY
AccessioniPrimary (citable) accession number: A0A1D2WUQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: March 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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