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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Cochliomyia macellaria (Secondary screw-worm)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiCochliomyia macellaria (Secondary screw-worm)Imported
Taxonomic identifieri66361 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeChrysomyinaeCochliomyia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 42HelicalSequence analysisAdd BLAST31
Transmembranei63 – 85HelicalSequence analysisAdd BLAST23
Transmembranei105 – 130HelicalSequence analysisAdd BLAST26
Transmembranei142 – 169HelicalSequence analysisAdd BLAST28
Transmembranei189 – 210HelicalSequence analysisAdd BLAST22
Transmembranei231 – 250HelicalSequence analysisAdd BLAST20
Transmembranei262 – 284HelicalSequence analysisAdd BLAST23
Transmembranei296 – 318HelicalSequence analysisAdd BLAST23
Transmembranei338 – 359HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 369COX1InterPro annotationAdd BLAST369

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A1C9C5L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GHPGALIPDD QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD
60 70 80 90 100
MAFPRMNNMS FWLLPPALTL LLVSSMVENG AGTGWTVYPP LSSNIAHGGA
110 120 130 140 150
SVDLAIFSLH LAGISSILGA VNFITTVINM RSTGITFDRM PLFVWSVVIT
160 170 180 190 200
ALLLLLSLPV LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP
210 220 230 240 250
EVYILILPGF GMISHIISQE SGKKETFGSL GMIYAMLAIG LLGFIVWAHH
260 270 280 290 300
MFTVGMDVDT RAYFTSATMI IAVPTGIKIF SWLATLYGTQ LNYSPATLWA
310 320 330 340 350
LGFVFLFTVG GLTGVVLANS SIDIILHDTY YVVAHFHYVL SMGAVFAIMA
360
GFVHWYPLFT GVTLNSKLL
Length:369
Mass (Da):40,158
Last modified:November 30, 2016 - v1
Checksum:iE623C03E87A25F81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei369Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KX529523 Genomic DNA Translation: AOM63580.1

Similar proteinsi

Entry informationi

Entry nameiA0A1C9C5L9_COCMA
AccessioniPrimary (citable) accession number: A0A1C9C5L9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: May 23, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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