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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Listeria monocytogenes
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes DL-2,6-diaminopimelate from LL-2,6-diaminopimelate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Diaminopimelate epimerase (dapF), Diaminopimelate epimerase (dapF), Diaminopimelate epimerase (dapF), Diaminopimelate epimerase (dapF), Diaminopimelate epimerase (dapF)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes DL-2,6-diaminopimelate from LL-2,6-diaminopimelate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14SubstrateUniRule annotation1
Binding sitei73SubstrateUniRule annotation1
Active sitei82Proton donorUniRule annotation1
Binding sitei170SubstrateUniRule annotation1
Sitei172Could be important to modulate the pK values of the two catalytic cysteine residuesUniRule annotation1
Binding sitei206SubstrateUniRule annotation1
Sitei224Could be important to modulate the pK values of the two catalytic cysteine residuesUniRule annotation1
Active sitei233Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Lysine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00025

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotationSAAS annotation (EC:5.1.1.7UniRule annotationSAAS annotation)
Short name:
DAP epimeraseUniRule annotation
Alternative name(s):
PLP-independent amino acid racemaseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
ORF Names:CDR86_01110Imported
OrganismiListeria monocytogenesImported
Taxonomic identifieri1639 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000219545 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A1C7Q0B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Substrate bindingUniRule annotation2
Regioni224 – 225Substrate bindingUniRule annotation2
Regioni234 – 235Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01778

Family and domain databases

HAMAPiMF_00197 DAP_epimerase, 1 hit
InterProiView protein in InterPro
IPR018510 DAP_epimerase_AS
IPR001653 DAP_epimerase_DapF
PANTHERiPTHR31689 PTHR31689, 1 hit
PfamiView protein in Pfam
PF01678 DAP_epimerase, 2 hits
TIGRFAMsiTIGR00652 DapF, 1 hit
PROSITEiView protein in PROSITE
PS01326 DAP_EPIMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1C7Q0B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIHFTKVH GSQNDFFLVD EEGNQIMDWS DAKRADFAIK LCDREHSLGG
60 70 80 90 100
ADGILYVTKS SEAGPIGQMR VVNSDGSIAS MCGNGLRTVA RYLLEKHALT
110 120 130 140 150
EAKVETMKAI LDVKKATSLG FDIPTYQVEI SPVKFNAESL PMNVGVEKLF
160 170 180 190 200
NQVVPELDAE LAFSAVSVPN PHLITFVDQT VLDSDRQETL ASYLNSENPY
210 220 230 240 250
FPDGVNVSFV KRLSDDAIYV RTFERGVGFT NACGTAMSAC SLIKKMLDKD
260 270 280 290 300
TFETPLNVYN DGGRVQVTAK KDEAGDISLQ LIGNATFVST GSVSYESDTV
310 320
TELTNEATPE QAQYQELVKE VKEFLKTTE
Length:329
Mass (Da):36,071
Last modified:November 30, 2016 - v1
Checksum:i9B5992BFDAEA83CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NYQU01000001 Genomic DNA Translation: PDM13512.1
RefSeqiWP_010989871.1, NZ_PXXI01000016.1

Genome annotation databases

KEGGilmom:IJ09_15125

Similar proteinsi

Entry informationi

Entry nameiA0A1C7Q0B1_LISMN
AccessioniPrimary (citable) accession number: A0A1C7Q0B1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: July 18, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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