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UniProtKB - A0A1C6V5H1 (A0A1C6V5H1_9ACTN)

Entry version 21 (07 Oct 2020)
Sequence version 1 (02 Nov 2016)
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Protein

Histidine kinase

Gene

GA0070603_3236

Organism
Micromonospora chersina
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.ARBA annotation EC:2.7.13.3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImportedARBA annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine kinaseARBA annotation (EC:2.7.13.3ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GA0070603_3236Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMicromonospora chersinaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri47854 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Micromonosporales › Micromonosporaceae › Micromonospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000198605 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini551 – 656Histidine kinaseInterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni666 – 1020DisorderedSequence analysisAdd BLAST355
Regioni1033 – 1233DisorderedSequence analysisAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi793 – 813PolarSequence analysisAdd BLAST21
Compositional biasi814 – 841Pro-richSequence analysisAdd BLAST28
Compositional biasi884 – 898PolarSequence analysisAdd BLAST15
Compositional biasi919 – 955Pro-richSequence analysisAdd BLAST37
Compositional biasi986 – 1004Pro-richSequence analysisAdd BLAST19
Compositional biasi1071 – 1085PolarSequence analysisAdd BLAST15
Compositional biasi1192 – 1233PolarSequence analysisAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003660, HAMP_dom
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR013587, Nitrate/nitrite_sensing

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00672, HAMP, 1 hit
PF02518, HATPase_c, 1 hit
PF08376, NIT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00304, HAMP, 1 hit
SM00387, HATPase_c, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50109, HIS_KIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1C6V5H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRPTTAGS FLSRLSRPAS RLRDMPIWSK LGLIMIVPTI ATVVVGTSGL 
        60         70         80         90        100
VDHLETLNNA NRAGDLANLV AYSGDLADRL QDERVTSVLF LTAKEVQTRA 
       110        120        130        140        150
QYQEAYNRAN QRVDQAKGPY SDQRRTIEDL PRTFEARLKD VDDGLADLPG 
       160        170        180        190        200
TRSQVYNGKF TGDEARTNYE ALISDLLAIR DSAIQLAGDN DLSDQMRAAA 
       210        220        230        240        250
AVARQKEYLA QRRVVVHQAL TQQSLTQNLR QQFTASETGG TQALESFKAV 
       260        270        280        290        300
ANQADSEFFD QTVSGPDKRE ADLYTGLIRN NISGKLDSPP FTRDQWDGAM 
       310        320        330        340        350
VANAKLIRTV ETRLDGNVVR HADELRSDTQ RQVFLETGLL LSMLLLAILF 
       360        370        380        390        400
AYLVARSMAR SLRDLRQGAL SVAQYGLPQA VARLRDPQVT GQLSPVQLAN 
       410        420        430        440        450
QIAEPLPVRS KDEFGQVTEA FNAVHLEAVR TAAEQAALRA SVATMFVNLA 
       460        470        480        490        500
RRSQILVDRL IGHLDRLERG EEDPDRLAEL FQLDHLATRM RRNDENLLVL 
       510        520        530        540        550
AGADSTRVQR EPAALIDVLR AAQSEVEHYT RIEFGVIDRD IEVAAHAVND 
       560        570        580        590        600
LVHLVAELFD NATAFSPPDS HVMVEARRVG DRASLYVEDR GIGISHEQLR 
       610        620        630        640        650
ELNERLATPP QVDVAVSRMM GLVVVARLAS RHGVKVELRP GGDRGTVADV 
       660        670        680        690        700
TLPTSVLVPR ALAGRGQPAP ALPAATGPQQ GGLAPAFGAG PQQGGPTPAF 
       710        720        730        740        750
GALAALGNGP HTPPPAPHPG ASGNQVTLGG RSFDPAPRNG SGTPANAGAG 
       760        770        780        790        800
RSMPAWSDLT GAGPLAGGDG FTPRSSNGQQ IDPLPQRRTP AEADPASTGQ 
       810        820        830        840        850
QPAIPRQLPS SPETRGYNPP PVSAPPVPPV SAPPLPPVSG VPVSGHPVSG 
       860        870        880        890        900
SPASGYPVSG APSSGYPVSG APSAGYPVSG SPAQGYPVSG SPAQGYPVSG 
       910        920        930        940        950
SPAQGYPVSG VPAFGQPVSA APAPVPPVTQ VPPRPAPPAP APQVGAPPVW 
       960        970        980        990       1000
PPVATPDQGA APAVPERLAA GLDMTTELPR VTRPETPPAV TAPAPAPVPA 
      1010       1020       1030       1040       1050
PRPTTPQQAG NRQRYADETM ELPIFRELES AWFRTRKPGP NEEAAAAPAA 
      1060       1070       1080       1090       1100
AANSAATQQF AKVDAAGRAV QQTPPGTTGN TPMAHTPTAG GAPHDNGSAN 
      1110       1120       1130       1140       1150
GGTRPGYAGA LPTRQPAAPP QPGWQTAADD GWRAASAATE VPVAETTQKG 
      1160       1170       1180       1190       1200
LPKRKPMAQL VPGGIEKPST SVQRRTPEGV RGLLSAYHRG VQRGRNNPTD 
      1210       1220       1230 
SNSTGPEGTP GGQQSSQSGS GPVAGSGQKE QQG
Length:1,233
Mass (Da):129,485
Last modified:November 2, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF131274E81E46928
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FMIB01000002 Genomic DNA Translation: SCL61592.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FMIB01000002 Genomic DNA Translation: SCL61592.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

Gene3Di3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR003660, HAMP_dom
IPR003594, HATPase_C
IPR036890, HATPase_C_sf
IPR005467, His_kinase_dom
IPR013587, Nitrate/nitrite_sensing
PfamiView protein in Pfam
PF00672, HAMP, 1 hit
PF02518, HATPase_c, 1 hit
PF08376, NIT, 1 hit
SMARTiView protein in SMART
SM00304, HAMP, 1 hit
SM00387, HATPase_c, 1 hit
SUPFAMiSSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS50109, HIS_KIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1C6V5H1_9ACTN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1C6V5H1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: October 7, 2020
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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