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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
uncultured Clostridium sp.
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:SAMEA3545266_01894Imported
Organismiuncultured Clostridium sp.Imported
Taxonomic identifieri59620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridiumenvironmental samples

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 186tRNA-synt_1gInterPro annotationAdd BLAST147
Domaini219 – 400tRNA-synt_1_2InterPro annotationAdd BLAST182
Domaini415 – 604tRNA-synt_1InterPro annotationAdd BLAST190
Domaini662 – 777Anticodon_1InterPro annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili274 – 294Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi576 – 580"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1C6JRB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYGTAIDK KWQKKWEETE LYKFNPDAEG EKLYVLEMFS YPSGSQLHAG
60 70 80 90 100
HWFNYGPVDS WARLKKMQGY NVFQPMGFDA FGLPAENFAI KTGIHPWDST
110 120 130 140 150
EKNIKTMEEQ LRAMGAMFNW ENEVITCTPE YYKWTQWVFL QLLKNGLAYR
160 170 180 190 200
KKAPVNWCPS CNTVLANEQV VDGACERCST EVTKKDLTQW FFKITEYADE
210 220 230 240 250
LLEKLDTLDW PEKTVAMQKH WIGKSTGAEV NFKVKNSDIN FNVFTTRVDT
260 270 280 290 300
LNGVTYVVLA PENPLVDELT TDENKAAVEE YKEAAKKQSD IERQSLTREK
310 320 330 340 350
TGVFTGSYAI NPINGKEVPV WVGDYVLATY GTGAVMAVPA HDERDYAFAT
360 370 380 390 400
KFNLPIDQVI TSKKGEEVEL PYCEYGVLVN SGEFDGLTTE EAKEAIVEKL
410 420 430 440 450
AKQGLGSAKV NYRLRDWLVS RQRYWGAPIP IIYCEDCGAV PVPEKDLPVE
460 470 480 490 500
LPYNVEFAPD GKSPLAKCEE FVNTTCPCCG KPAKRECDTL DTFVCSSWYQ
510 520 530 540 550
MRYVDNKNDK IAFDKEKVDK MLPVDKYVGG PEHACMHLLY ARFITKALRD
560 570 580 590 600
MGYLSFDEPF KSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR
610 620 630 640 650
MYLMFGFAYT EGGAWSDDGI KSVARFVDRI ERYLTMCREA IEAGTNNKTT
660 670 680 690 700
MDKAEKELNF WLNNAIKGVT EDGEKMQFNT AIARMMEFIN ALSKYMKEET
710 720 730 740 750
KNLDFLKNVC ESFIKILAPF APHFAEEQWS LLTGKYSVFN ESWPAFDAKA
760 770 780 790 800
LVKDEIEIAI QVNGKIKARI NVASDLNEEG IKAAALADEA VIAATEGKTI
810
VKVIVIKGRL VNIVVK
Length:816
Mass (Da):92,414
Last modified:November 2, 2016 - v1
Checksum:i059D60C013DF87F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FMHE01000014 Genomic DNA Translation: SCJ84573.1

Similar proteinsi

Entry informationi

Entry nameiA0A1C6JRB3_9CLOT
AccessioniPrimary (citable) accession number: A0A1C6JRB3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: March 28, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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