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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
uncultured Eubacterium sp.
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD), Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotationImported
ORF Names:SAMEA3545372_00987Imported
Organismiuncultured Eubacterium sp.Imported
Taxonomic identifieri165185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacteriumenvironmental samples

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 173CTP_transf_likeInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the NadD family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02165 NMNAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00244 NaMN_adenylyltr, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR005248 NadD/NMNAT
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00482 TIGR00482, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1C5ZAQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIGILGGT FNPIHHGHLI LGQAAKEEFG LDEILVMPTK NPAYKTISGG
60 70 80 90 100
VTEQNRVDMI KLAIAGFSYF RFSDMELNRE GTTYTVDTLR ALTKENTDCR
110 120 130 140 150
YYFIMGADSL YQIETWKDPD QIFAMADILV ATRNDSRSAL DAQIDYLEEK
160 170 180 190 200
YGGKIYHLSS PSIEISSNDI RKRCKNGSSI HFFLPENVID YIERNDLYGI

TADRR
Length:205
Mass (Da):23,307
Last modified:November 2, 2016 - v1
Checksum:i7912B23A17AF3887
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FMFW01000007 Genomic DNA Translation: SCI56689.1

Similar proteinsi

Entry informationi

Entry nameiA0A1C5ZAQ7_9FIRM
AccessioniPrimary (citable) accession number: A0A1C5ZAQ7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: March 28, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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