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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
ORF Names:BBG01_09315Imported, BBG03_09395Imported
OrganismiStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)Imported
Taxonomic identifieri119602 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000092682 Componenti: Unassembled WGS sequence
  • UP000092549 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 327tRNA-synt_1cInterPro annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 22"HIGH" regionUniRule annotationAdd BLAST11
Motifi256 – 260"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1B8VRE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKPIRVRY APSPTGLLHI GNARTALFNY LYARHHGGTF IIRIEDTDRK
60 70 80 90 100
RHVEDGERSQ LENLKWLGMD WDESPETHEQ YRQSERLDLY QKYIDQLLAE
110 120 130 140 150
GKAYKSYVTE DELAAERERQ EAAGETPRYI NEFLGMTEEQ KAAYIAEREA
160 170 180 190 200
AGIVPTVRLA VNEAGIYKWT DMVKGDIEFE GGNIGGDWVI QKKDGYPTYN
210 220 230 240 250
FAVVVDDHDM QISHVIRGDD HIANTPKQLM VYEALGWEAP AFGHMTLIIN
260 270 280 290 300
SETGKKLSKR DTNTLQFIED YRKKGYMPEA VFNFIALLGW NPGGEEEIFS
310 320 330 340 350
REQLIDLFDE NRLSKSPAAF DQKKMDWMSN EYLKNADFET VYALCKPFLE
360 370 380 390 400
EAGRLTEKAE KLVELYKPQL KSADEIIPLT DLFFSDFPEL TEAEKEVMAG
410 420 430 440 450
ETVPTVLQAF KEKLEAMSDE DFKPENIFPQ IKAVQKETGI KGKNLFMPIR
460 470 480
IAVSGEMHGP ELPNTIYLLG RDKSIEHINK ML
Length:482
Mass (Da):55,263
Last modified:November 2, 2016 - v1
Checksum:iD6848674FE30BB6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MATW01000025 Genomic DNA Translation: OBY99132.1
MATX01000006 Genomic DNA Translation: OBZ00499.1
RefSeqiWP_003053372.1, NZ_MCRQ01000005.1

Genome annotation databases

EnsemblBacteriaiOBY99132; OBY99132; BBG03_09395
OBZ00499; OBZ00499; BBG01_09315
GeneIDi13902425
PATRICifig|119602.30.peg.190

Similar proteinsi

Entry informationi

Entry nameiA0A1B8VRE3_STREQ
AccessioniPrimary (citable) accession number: A0A1B8VRE3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: March 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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