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Protein

ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Gene

K503DRAFT_689222

Organism
Rhizopogon vinicolor AM-OR11-026
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation

Catalytic activityi

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei111NAD(P)HX; via amide nitrogenUniRule annotation1
Binding sitei254NAD(P)HXUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ATPUniRule annotation5
Nucleotide bindingi244 – 253ATPUniRule annotation10

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, LyaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)
Alternative name(s):
ATP-dependent NAD(P)HX dehydrataseUniRule annotation
Gene namesi
ORF Names:K503DRAFT_689222Imported
OrganismiRhizopogon vinicolor AM-OR11-026Imported
Taxonomic identifieri1314800 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeBoletalesSuillineaeRhizopogonaceaeRhizopogon
Proteomesi
  • UP000092154 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 170NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrD/CARKD family.UniRule annotation

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 2 hits
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1B7N434-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVPRTVIEQ IKQIIPPLNG SLHKGQSGRV GVLGGAFDYT GAPFFAAISA
60 70 80 90 100
LRLGADLSHV ICAPTAAQAI KSYSPDLIVH PILSEEAAPG TVEETLRSLL
110 120 130 140 150
SRLHVLVMGP GLGREAYMQS YARMALSIAR ERAMFVVLDA DALWMVQEDL
160 170 180 190 200
RLIEGYRRAV LTPNVVEFKR LSESAGISPD VPAKERAAEL SRRLGGVVVL
210 220 230 240 250
EKGATDLIAS DTTGEAASLE VSGVDGEDGE RQRLREVVEV DVEGGLKRCG
260 270 280 290 300
GQGDVLSGTV GAMLAWGKCY EDGAFGDGSI PVSRLPLLAA VGGSMVTRTS
310 320 330 340
SRRAFQLEGR GLVTQDMLPQ LGKSFSEVFG EDLWAGEKGR L
Length:341
Mass (Da):36,285
Last modified:November 2, 2016 - v1
Checksum:iB656650182A1B195
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV448243 Genomic DNA Translation: OAX39613.1

Genome annotation databases

EnsemblFungiiOAX39613; OAX39613; K503DRAFT_689222

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KV448243 Genomic DNA Translation: OAX39613.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiOAX39613; OAX39613; K503DRAFT_689222

Family and domain databases

CDDicd01171 YXKO-related, 1 hit
Gene3Di3.40.1190.20, 1 hit
HAMAPiMF_01965 NADHX_dehydratase, 1 hit
InterProiView protein in InterPro
IPR017953 Carbohydrate_kinase_pred_CS
IPR000631 CARKD
IPR029056 Ribokinase-like
PfamiView protein in Pfam
PF01256 Carb_kinase, 2 hits
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00196 yjeF_cterm, 1 hit
PROSITEiView protein in PROSITE
PS01050 YJEF_C_2, 1 hit
PS51383 YJEF_C_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1B7N434_9HOMO
AccessioniPrimary (citable) accession number: A0A1B7N434
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: September 27, 2017
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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