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Entry version 16 (12 Aug 2020)
Sequence version 1 (05 Oct 2016)
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Protein
Submitted name:

Glutamine-rich protein 2

Gene

QRICH2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glutamine-rich protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QRICH2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25326, QRICH2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000129646

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A1B0GW36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A1B0GW36, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 104DisorderedSequence analysisAdd BLAST56
Regioni246 – 405DisorderedSequence analysisAdd BLAST160
Regioni741 – 779DisorderedSequence analysisAdd BLAST39
Regioni1046 – 1091DisorderedSequence analysisAdd BLAST46
Regioni1114 – 1149DisorderedSequence analysisAdd BLAST36
Regioni1775 – 1829DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1295 – 1322Sequence analysisAdd BLAST28
Coiled coili1454 – 1491Sequence analysisAdd BLAST38
Coiled coili1529 – 1549Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 69PolarSequence analysisAdd BLAST21
Compositional biasi246 – 273PolarSequence analysisAdd BLAST28
Compositional biasi281 – 315PolarSequence analysisAdd BLAST35
Compositional biasi335 – 352PolyampholyteSequence analysisAdd BLAST18
Compositional biasi368 – 382PolarSequence analysisAdd BLAST15
Compositional biasi1051 – 1077PolarSequence analysisAdd BLAST27
Compositional biasi1775 – 1790PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1800 – 1829PolarSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161294

Identification of Orthologs from Complete Genome Data

More...
OMAi
TDQRSME

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032013, DUF4795

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16043, DUF4795, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A1B0GW36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPATTVSLR ELADLSIGTP EVGAVNFTAL HTLIVAMLKN LDLQNTRIDF
60 70 80 90 100
QPSSPEPSRS LQSVRSSFSI PHLPAPKEVP KGAPREKRRG VGQAPSSALE
110 120 130 140 150
SQVKDLGGQV EDLSKQLKRV DGQVQGIATH VQHFSQASGL DLAALEWPEE
160 170 180 190 200
QEVGVRAFDR VRTGSIMKDA AEELSFARVL LQRVDELEKL FKDREQFLEL
210 220 230 240 250
VSRKLSLVPG AEEVTMVTWE ELEQAITDGW RASQAGSETL MGFSKHGGFT
260 270 280 290 300
SLTSPEGTLS GDSTKQPSIE QALDSASGLG PDRTASGSGG TAHPSDGVSS
310 320 330 340 350
REQSKVPSGT GRQQQPRARD EAGVPRLHQS STFQFKSDSD RHRSREKLTS
360 370 380 390 400
TQPRRNARPG PVQQDLPLAR DQPSSVPASQ SQVHLRPDRR GLEPTGMNQP
410 420 430 440 450
GLVPASTYPH GVVPLSMGQL GVPPPEMDDR ELIPFVVDEQ RMLPPSVPGR
460 470 480 490 500
DQQGLELPST DQHGLVSVSA YQHGMTFPGT DQRSMEPLGM DQRGCVISGM
510 520 530 540 550
GQQGLVPPGI DQQGLTLPVV DQHGLVLPFT DQHGLVSPGL MPISADQQGF
560 570 580 590 600
VQPSLEATGF IQPGTEQHDL IQSGRFQRAL VQRGAYQPGL VQPGADQRGL
610 620 630 640 650
VRPGMDQSGL AQPGADQRGL VWPGMDQSGL AQPGRDQHGL IQPGTGQHDL
660 670 680 690 700
VQSGTGQGVL VQPGVDQPGM VQPGRFQRAL VQPGAYQPGL VQPGADQIDV
710 720 730 740 750
VQPGADQHGL VQSGADQSDL AQPGAVQHGL VQPGVDQRGL AQPRADHQRG
760 770 780 790 800
LVPPGADQRG LVQPGADQHG LVQPGVDQHG LAQPGEVQRS LVQPGIVQRG
810 820 830 840 850
LVQPGAVQRG LVQPGAVQRG LVQPGVDQRG LVQPGAVQRG LVQPGAVQHG
860 870 880 890 900
LVQPGADQRG LVQPGVDQRG LVQPGVDQRG LVQPGMDQRG LIQPGADQPG
910 920 930 940 950
LVQPGAGQLG MVQPGIGQQG MVQPQADPHG LVQPGAYPLG LVQPGAYLHD
960 970 980 990 1000
LSQSGTYPRG LVQPGMDQYG LRQPGAYQPG LIAPGTKLRG SSTFQADSTG
1010 1020 1030 1040 1050
FISVRPYQHG MVPPGREQYG QVSPLLASQG LASPGIDRRS LVPPETYQQG
1060 1070 1080 1090 1100
LMHPGTDQHS PIPLSTGLGS THPDQQHVAS PGPGEHDQVY PDAAQHGHAF
1110 1120 1130 1140 1150
SLFDSHDSMY PGYRGPGYLS ADQHGQEGLD PNRTRASDRH GIPAQKAPGQ
1160 1170 1180 1190 1200
DVTLFRSPDS VDRVLSEGSE VSSEVLSERR NSLRRMSSSF PTAVETFHLM
1210 1220 1230 1240 1250
GELSSLYVGL KESMKDLDEE QAGQTDLEKI QFLLAQMVKR TIPPELQEQL
1260 1270 1280 1290 1300
KTVKTLAKEV WQEKAKVERL QRILEGEGNQ EAGKELKAGE LRLQLGVLRV
1310 1320 1330 1340 1350
TVADIEKELA ELRESQDRGK AAMENSVSEA SLYLQDQLDK LRMIIESMLT
1360 1370 1380 1390 1400
SSSTLLSMSM APHKAHTLAP GQIDPEATCP ACSLDVSHQV STLVRRYEQL
1410 1420 1430 1440 1450
QDMVNSLAVS RPSKKAKLQR QDEELLGRVQ SAILQVQGDC EKLNITTSNL
1460 1470 1480 1490 1500
IEDHRQKQKD IAMLYQGLEK LEKEKANREH LEMEIDVKAD KSALATKVSR
1510 1520 1530 1540 1550
VQFDATTEQL NHMMQELVAK MSGQEQDWQK MLDRLLTEMD NKLDRLELDP
1560 1570 1580 1590 1600
VKQLLEDRWK SLRQQLRERP PLYQADEAAA MRRQLLAHFH CLSCDRPLET
1610 1620 1630 1640 1650
PVTGHAIPVT PAGPGLPGHH SIRPYTVFEL EQVRQHSRNL KLGSAFPRGD
1660 1670 1680 1690 1700
LAQMEQSVGR LRSMHSKMLM NIEKVQIHFG GSTKASSQII RELLHAQCLG
1710 1720 1730 1740 1750
SPCYKRVTDM ADYTYSTVPR RCGGSHTLTY PYHRSRPQHL PRGLYPTEEI
1760 1770 1780 1790 1800
QIAMKHDEVD ILGLDGHIYK GRMDTRLPGI LRKDSSGTSK RKSQQPRPHV
1810 1820
HRPPSLSSNG QLPSRPQSAQ ISAGNTSER
Length:1,829
Mass (Da):198,717
Last modified:October 5, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5CD10045D96124F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H0J4QRIC2_HUMAN
Glutamine-rich protein 2
QRICH2
1,663Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDB9H0YDB9_HUMAN
Glutamine-rich protein 2
QRICH2
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0E3H7C0E3_HUMAN
Glutamine-rich protein 2
QRICH2
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPH7E9PPH7_HUMAN
Glutamine-rich protein 2
QRICH2
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC015801 Genomic DNA No translation available.
AC090699 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000636395; ENSP00000490761; ENSG00000129646

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015801 Genomic DNA No translation available.
AC090699 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A1B0GW36

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19682, 17 antibodies

Genome annotation databases

EnsembliENST00000636395; ENSP00000490761; ENSG00000129646

Organism-specific databases

HGNCiHGNC:25326, QRICH2
OpenTargetsiENSG00000129646

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000161294
OMAiTDQRSME

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
QRICH2, human

Gene expression databases

ExpressionAtlasiA0A1B0GW36, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR032013, DUF4795
PfamiView protein in Pfam
PF16043, DUF4795, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1B0GW36_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1B0GW36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: August 12, 2020
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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