Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 2

Gene

KCNQ2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily KQT member 2Imported
Gene namesi
Name:KCNQ2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:6296 KCNQ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 79HelicalSequence analysisAdd BLAST19
Transmembranei120 – 145HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075043

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500840867417 – 671Sequence analysisAdd BLAST655

Proteomic databases

PeptideAtlasiA0A1B0GW14

Expressioni

Gene expression databases

ExpressionAtlasiA0A1B0GW14 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 145Ion_transInterPro annotationAdd BLAST142
Domaini265 – 449KCNQ_channelInterPro annotationAdd BLAST185

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074513

Family and domain databases

InterProiView protein in InterPro
IPR020969 Ankyrin-G_BS
IPR005821 Ion_trans_dom
IPR003947 K_chnl_volt-dep_KCNQ2
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PF11956 KCNQC3-Ank-G_bd, 1 hit
PRINTSiPR00169 KCHANNEL

Sequencei

Sequence statusi: Complete.

A0A1B0GW14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIASIAVL AAGSQGNVFA TSALRSLRFL QILRMIRMDR RGGTWKLLGS
60 70 80 90 100
VVYAHSKELV TAWYIGFLCL ILASFLVYLA EKGENDHFDT YADALWWGLI
110 120 130 140 150
TLTTIGYGDK YPQTWNGRLL AATFTLIGVS FFALPAGILG SGFALKVQEQ
160 170 180 190 200
HRQKHFEKRR NPAAGLIQSA WRFYATNLSR TDLHSTWQYY ERTVTVPMYR
210 220 230 240 250
LIPPLNQLEL LRNLKSKSGL AFRKDPPPEP SPSQKVSLKD RVFSSPRGVA
260 270 280 290 300
AKGKGSPQAQ TVRRSPSADQ SLEDSPSKVP KSWSFGDRSR ARQAFRIKGA
310 320 330 340 350
ASRQNSEEAS LPGEDIVDDK SCPCEFVTED LTPGLKVSIR AVCVMRFLVS
360 370 380 390 400
KRKFKESLRP YDVMDVIEQY SAGHLDMLSR IKSLQSRVDQ IVGRGPAITD
410 420 430 440 450
KDRTKGPAEA ELPEDPSMMG RLGKVEKQVL SMEKKLDFLV NIYMQRMGIP
460 470 480 490 500
PTETEAYFGA KEPEPAPPYH SPEDSREHVD RHGCIVKIVR SSSSTGQKNF
510 520 530 540 550
SAPPAAPPVQ CPPSTSWQPQ SHPRQGHGTS PVGDHGSLVR IPPPPAHERS
560 570 580 590 600
LSAYGGGNRA SMEFLRQEDT PGCRPPEGNL RDSDTSISIP SVDHEELERS
610 620 630 640 650
FSGFSISQSK ENLDALNSCY AAVAPCAKVR PYIAEGESDT DSDLCTPCGP
660 670
PPRSATGEGP FGDVGWAGPR K
Length:671
Mass (Da):73,916
Last modified:October 5, 2016 - v1
Checksum:i408967F7F91D7834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA No translation available.
AL121829 Genomic DNA No translation available.
AL353658 Genomic DNA No translation available.
KF456987 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000637193; ENSP00000490734; ENSG00000075043

Similar proteinsi

Entry informationi

Entry nameiA0A1B0GW14_HUMAN
AccessioniPrimary (citable) accession number: A0A1B0GW14
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health