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Protein
Submitted name:

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Gene

CACNA1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent P/Q-type calcium channel subunit alpha-1AImported
Gene namesi
Name:CACNA1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1388 CACNA1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 53HelicalSequence analysisAdd BLAST19
Transmembranei65 – 88HelicalSequence analysisAdd BLAST24
Transmembranei158 – 176HelicalSequence analysisAdd BLAST19
Transmembranei254 – 278HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141837

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A1B0GVX1

Expressioni

Gene expression databases

ExpressionAtlasiA0A1B0GVX1 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini415 – 449Ca_chan_IQInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00830000128247

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00167 CACHANNEL
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

A0A1B0GVX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DFAISAKPLT RHMPQNKQSF QYRMWQFVVS PPFEYTIMAM IALNTIVLMM
60 70 80 90 100
KFYGASVAYE NALRVFNIVF TSLFSLECVL KVMAFGILNY FRDAWNIFDF
110 120 130 140 150
VTVLGSITDI LVTEFGNPNN FINLSFLRLF RAARLIKLLR QGYTIRILLW
160 170 180 190 200
TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIGIDVED EDSDEDEFQI
210 220 230 240 250
TEHNNFRTFF QALMLLFRSA TGEAWHNIML SCLSGKPCDK NSGILTRECG
260 270 280 290 300
NEFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEYV
310 320 330 340 350
RVWAEYDPAA CGRIHYKDMY SLLRVISPPL GLGKKCPHRV ACKRLLRMDL
360 370 380 390 400
PVADDNTVHF NSTLMALIRT ALDIKIAKGG ADKQQMDAEL RKEMMAIWPN
410 420 430 440 450
LSQKTLDLLV TPHKSTDLTV GKIYAAMMIM EYYRQSKAKK LQAMREEQDR

TPLMFQRME
Length:459
Mass (Da):53,135
Last modified:October 5, 2016 - v1
Checksum:i745D3D6A74EA58AE
GO

Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O00555CAC1A_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A CACH4, CACN3, CACNL1A4
2,506Annotation score:
A0A087WW63A0A087WW63_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,512Annotation score:
B5TYJ1B5TYJ1_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,263Annotation score:
A0A1B0GVQ9A0A1B0GVQ9_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,266Annotation score:
A0A1B0GTN7A0A1B0GTN7_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,507Annotation score:
A0A1C7CYY9A0A1C7CYY9_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,508Annotation score:
A0A1B0GUS3A0A1B0GUS3_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,495Annotation score:
A0A1B0GU74A0A1B0GU74_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,302Annotation score:
A0A1B0GTI4A0A1B0GTI4_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,262Annotation score:
A0A1B0GTW2A0A1B0GTW2_HUMAN
Voltage-dependent P/Q-type calcium ...
CACNA1A
2,460Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei459Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005305 Genomic DNA No translation available.
AC005513 Genomic DNA No translation available.
AC011446 Genomic DNA No translation available.
AC022436 Genomic DNA No translation available.
AC026805 Genomic DNA No translation available.
AC093062 Genomic DNA No translation available.
AC098781 Genomic DNA No translation available.
AC124224 Genomic DNA No translation available.
KF456505 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000637819; ENSP00000490686; ENSG00000141837

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005305 Genomic DNA No translation available.
AC005513 Genomic DNA No translation available.
AC011446 Genomic DNA No translation available.
AC022436 Genomic DNA No translation available.
AC026805 Genomic DNA No translation available.
AC093062 Genomic DNA No translation available.
AC098781 Genomic DNA No translation available.
AC124224 Genomic DNA No translation available.
KF456505 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A1B0GVX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000637819; ENSP00000490686; ENSG00000141837

Organism-specific databases

HGNCiHGNC:1388 CACNA1A
OpenTargetsiENSG00000141837
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00830000128247

Miscellaneous databases

ChiTaRSiCACNA1A human

Gene expression databases

ExpressionAtlasiA0A1B0GVX1 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00167 CACHANNEL
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1B0GVX1_HUMAN
AccessioniPrimary (citable) accession number: A0A1B0GVX1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: March 28, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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