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UniProtKB - A0A1B0GVI4 (A0A1B0GVI4_HUMAN)
Protein
Submitted name:
Myocyte-specific enhancer factor 2C
Gene
MEF2C
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProt
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: UniProt
GO - Biological processi
- animal organ development Source: UniProt
- positive regulation of transcription, DNA-templated Source: UniProt
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Myocyte-specific enhancer factor 2CImported |
Gene namesi | Name:MEF2CImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6996, MEF2C |
VEuPathDBi | HostDB:ENSG00000081189 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 42 | MADS-boxInterPro annotationAdd BLAST | 42 |
Phylogenomic databases
GeneTreei | ENSGT00940000157492 |
Family and domain databases
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS50066, MADS_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ06413 | MEF2C_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 473 | Annotation score: | ||
A0A0D9SGI5 | A0A0D9SGI5_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 471 | Annotation score: | ||
D6RJG6 | D6RJG6_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 399 | Annotation score: | ||
A0A0R4J2G5 | A0A0R4J2G5_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 433 | Annotation score: | ||
A0A0D9SFD0 | A0A0D9SFD0_HUMAN | MADS box transcription enhancer fac... | MEF2C hCG_36839 | 431 | Annotation score: | ||
A0A1B0GV32 | A0A1B0GV32_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 462 | Annotation score: | ||
D8L7E9 | D8L7E9_HUMAN | Myocyte enhancer factor 2c | MEF2C | 393 | Annotation score: | ||
D6RCM6 | D6RCM6_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 129 | Annotation score: | ||
D6RG21 | D6RG21_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 126 | Annotation score: | ||
D6RJA7 | D6RJA7_HUMAN | Myocyte-specific enhancer factor 2C | MEF2C | 194 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 42 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008525 Genomic DNA No translation available. AC008835 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000635898; ENSP00000490525; ENSG00000081189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008525 Genomic DNA No translation available. AC008835 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 755, 1307 antibodies from 36 providers |
Genome annotation databases
Ensembli | ENST00000635898; ENSP00000490525; ENSG00000081189 |
Organism-specific databases
HGNCi | HGNC:6996, MEF2C |
OpenTargetsi | ENSG00000081189 |
VEuPathDBi | HostDB:ENSG00000081189 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157492 |
Miscellaneous databases
ChiTaRSi | MEF2C, human |
Gene expression databases
ExpressionAtlasi | A0A1B0GVI4, baseline and differential |
Family and domain databases
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS50066, MADS_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1B0GVI4_HUMAN | |
Accessioni | A0A1B0GVI4Primary (citable) accession number: A0A1B0GVI4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2016 |
Last sequence update: | October 5, 2016 | |
Last modified: | January 19, 2022 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |