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UniProtKB - A0A1B0GV49 (A0A1B0GV49_HUMAN)
Protein
Aldehyde dehydrogenase (NAD(+))
Gene
ALDH7A1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:1.2.1.3ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 229 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- aldehyde dehydrogenase (NAD+) activity Source: UniProtKB-EC
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Source: UniProtKB-EC
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ALDH7A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:877, ALDH7A1 |
VEuPathDBi | HostDB:ENSG00000164904 |
Interactioni
Subunit structurei
Homotetramer.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 452 | AldedhInterPro annotationAdd BLAST | 387 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154938 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR044638, ALDH7A1-like |
PANTHERi | PTHR43521, PTHR43521, 2 hits |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
A0A1B0GV49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWRLPRALCV HAAKTSKLSG PWSRPAAFMS TLLINQPQYA WLKELGLREE
60 70 80 90 100
NEGVYNGSWG GRGEVSLEMG KILVEGVGEV QEYVDICDYA VGLSRMIGGP
110 120 130 140 150
ILPSERSGHA LIEQWNPVGL VGIITAFNFP VAVYGWNNAI AMICGNVCLW
160 170 180 190 200
KGAPTTSLIS VAVTKIIAKV LEDNKLPGAI CSLTCGGADI GTAMAKDERV
210 220 230 240 250
NLLSFTGSTQ VGKQVGLMVQ ERFGRSLLEL GGNNAIIAFE DADLSLVVPS
260 270 280 290 300
ALFAAVGTAG QRCTTARRLF IHESIHDEVV NRLKKAYAQI RVGNPWDPNV
310 320 330 340 350
LYGPLHTKQA VSMFLGAVEE AKKEGGTVVY GGKVMDRPGN YVEPTIVTGL
360 370 380 390 400
GHDASIAHTE TFAPILYVFK FKNEEEVFAW NNEVKQGLSS SIFTKDLGRI
410 420 430 440 450
FRWLGPKGSD CGIVNVNIPT SGAEIGGAFG GEKHTGGGRE SGSDAWKQYM
460 470
RRSTCTINYS KDLPLAQGIK FQ
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP49419 | AL7A1_HUMAN | Alpha-aminoadipic semialdehyde dehy... | ALDH7A1 ATQ1 | 539 | Annotation score: | ||
A0A1B0GUA1 | A0A1B0GUA1_HUMAN | Aldehyde dehydrogenase (NAD(+)) | ALDH7A1 | 521 | Annotation score: | ||
A0A1B0GTJ4 | A0A1B0GTJ4_HUMAN | Aldehyde dehydrogenase (NAD(+)) | ALDH7A1 | 499 | Annotation score: | ||
A0A1B0GW77 | A0A1B0GW77_HUMAN | Aldehyde dehydrogenase (NAD(+)) | ALDH7A1 | 554 | Annotation score: | ||
A0A1B0GW82 | A0A1B0GW82_HUMAN | Aldehyde dehydrogenase (NAD(+)) | ALDH7A1 | 545 | Annotation score: | ||
A0A1B0GUY0 | A0A1B0GUY0_HUMAN | Aldehyde dehydrogenase (NAD(+)) | ALDH7A1 | 348 | Annotation score: | ||
A0A1B0GTG2 | A0A1B0GTG2_HUMAN | Alpha-aminoadipic semialdehyde dehy... | ALDH7A1 | 536 | Annotation score: | ||
F8VVF2 | F8VVF2_HUMAN | Alpha-aminoadipic semialdehyde dehy... | ALDH7A1 | 193 | Annotation score: | ||
H0YHM6 | H0YHM6_HUMAN | Alpha-aminoadipic semialdehyde dehy... | ALDH7A1 | 239 | Annotation score: | ||
F8WDY6 | F8WDY6_HUMAN | Alpha-aminoadipic semialdehyde dehy... | ALDH7A1 | 136 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093535 Genomic DNA No translation available. AC099513 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000636886; ENSP00000490371; ENSG00000164904 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093535 Genomic DNA No translation available. AC099513 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A1B0GV49 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1B0GV49 |
Protocols and materials databases
Antibodypediai | 13922, 267 antibodies from 28 providers |
Genome annotation databases
Ensembli | ENST00000636886; ENSP00000490371; ENSG00000164904 |
Organism-specific databases
HGNCi | HGNC:877, ALDH7A1 |
OpenTargetsi | ENSG00000164904 |
VEuPathDBi | HostDB:ENSG00000164904 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154938 |
Miscellaneous databases
ChiTaRSi | ALDH7A1, human |
Gene expression databases
ExpressionAtlasi | A0A1B0GV49, baseline and differential |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR044638, ALDH7A1-like |
PANTHERi | PTHR43521, PTHR43521, 2 hits |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1B0GV49_HUMAN | |
Accessioni | A0A1B0GV49Primary (citable) accession number: A0A1B0GV49 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2016 |
Last sequence update: | October 5, 2016 | |
Last modified: | January 19, 2022 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |