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UniProtKB - A0A1B0GV09 (A0A1B0GV09_HUMAN)
Protein
Submitted name:
Histone-lysine N-methyltransferase EHMT1
Gene
EHMT1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histone-lysine N-methyltransferase activity Source: InterPro
- p53 binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- chromatin organization Source: UniProt
Names & Taxonomyi
Protein namesi | Submitted name: Histone-lysine N-methyltransferase EHMT1Imported |
Gene namesi | Name:EHMT1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24650, EHMT1 |
VEuPathDBi | HostDB:ENSG00000181090 |
Subcellular locationi
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 741 – 773 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 774 – 806 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 807 – 831 | ANKPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 841 – 873 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 907 – 939 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 1029 – 1092 | Pre-SETInterPro annotationAdd BLAST | 64 | |
Domaini | 1095 – 1212 | SETInterPro annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 82 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 113 – 162 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 180 – 203 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 308 – 448 | DisorderedSequence analysisAdd BLAST | 141 | |
Regioni | 613 – 686 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 1243 – 1267 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 23 – 63 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 185 – 203 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 314 – 330 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 346 – 364 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 365 – 384 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 426 – 446 | Polar residuesSequence analysisAdd BLAST | 21 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000156002 |
OrthoDBi | 753093at2759 |
PhylomeDBi | A0A1B0GV09 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR038035, EHMT1 IPR043550, EHMT1/EHMT2 IPR007728, Pre-SET_dom IPR001214, SET_dom |
PANTHERi | PTHR46307, PTHR46307, 1 hit PTHR46307:SF2, PTHR46307:SF2, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF13637, Ank_4, 1 hit PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 7 hits SM00468, PreSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 5 hits PS50867, PRE_SET, 1 hit PS50280, SET, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
A0A1B0GV09-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAADEGSAEK QAGEAHMAAD GETNGSCENS DASSHANAAK HTQDSARVNP
60 70 80 90 100
QDGTNTLTRI AENGVSERDS EAAKQNHVTA DDFVQTSVIG SNGYILNKPA
110 120 130 140 150
LQAQPLRTTS TLASSLPGHA AKTLPGGAGK GRTPSAFPQT PAAPPATLGE
160 170 180 190 200
GSADTEDRKL PAPGADVKVH RARKTMPKSV VGLHAASKDP REVREARDHK
210 220 230 240 250
EPKEEINKNI SDFGRQQLLP PFPSLHQSLP QNQCYMATTK SQTACLPFVL
260 270 280 290 300
AAAVSRKKKR RMGTYSLVPK KKTKVLKQRT VIEMFKSITH STVGSKGEKD
310 320 330 340 350
LGASSLHVNG ESLEMDSDED DSEELEEDDG HGAEQAAAFP TEDSRTSKES
360 370 380 390 400
MSEADRAQKM DGESEEEQES VDTGEEEEGG DESDLSSESS IKKKFLKRKG
410 420 430 440 450
KTDSPWIKPA RKRRRRSRKK PSGALGSESY KSSAGSAEQT APGDSTGYME
460 470 480 490 500
VSLDSLDLRV KGILSSQAEG LANGPDVLET DGLQEVPLCS CRMETPKSRE
510 520 530 540 550
ITTLANNQCM ATESVDHELG RCTNSVVKYE LMRPSNKAPL LVLCEDHRGR
560 570 580 590 600
MVKHQCCPGC GYFCTAGNFM ECQPESSISH RFHKDCASRV NNASYCPHCG
610 620 630 640 650
EESSKAKEVT IAKADTTSTV TPVPGQEKGS ALEGRADTTT GSAAGPPLSE
660 670 680 690 700
DDKLQGAASH VPEGFDPTGP AGLGRPTPGL SQGPGKETLE SALIALDSEK
710 720 730 740 750
PKKLRFHPKQ LYFSARQGEL QKVLLMLVDG IDPNFKMEHQ NKRSPLHAAA
760 770 780 790 800
EAGHVDICHM LVQAGANIDT CSEDQRTPLM EAAENNHLEA VKYLIKAGAL
810 820 830 840 850
VDPKDAEGST CLHLAAKKGH YEVVQYLLSN GQMDVNCQDD GGWTPMIWAT
860 870 880 890 900
EYKHVDLVKL LLSKGSDINI RDNEENICLH WAAFSGCVDI AEILLAAKCD
910 920 930 940 950
LHAVNIHGDS PLHIAARENR YDCVVLFLSR DSDVTLKNKE GETPLQCASL
960 970 980 990 1000
NSQVWSALQM SKALQDSAPD RPSPVERIVS RDIARGYERI PIPCVNAVDS
1010 1020 1030 1040 1050
EPCPSNYKYV SQNCVTSPMN IDRNITHLQY CVCIDDCSSS NCMCGQLSMR
1060 1070 1080 1090 1100
CWYDKDGRLL PEFNMAEPPL IFECNHACSC WRNCRNRVVQ NGLRARLQLY
1110 1120 1130 1140 1150
RTRDMGWGVR SLQDIPPGTF VCEYVGELIS DSEADVREED SYLFDLDNKD
1160 1170 1180 1190 1200
GEVYCIDARF YGNVSRFINH HCEPNLVPVR VFMAHQDLRF PRIAFFSTRL
1210 1220 1230 1240 1250
IEAGEQLGFD YGERFWDIKG KLFSCRCGSP KCRHSSAALA QRQASAAQEA
1260
QEDGLPDTSS AAAADPL
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9H9B1 | EHMT1_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 EUHMTASE1, GLP, KIAA1876, KMT1D | 1,298 | Annotation score: | ||
A0A1B0GU48 | A0A1B0GU48_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 981 | Annotation score: | ||
A0A0D9SER3 | A0A0D9SER3_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 137 | Annotation score: | ||
A0A0D9SFG7 | A0A0D9SFG7_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 139 | Annotation score: | ||
A0A0D9SFS4 | A0A0D9SFS4_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 134 | Annotation score: | ||
A0A0D9SEQ1 | A0A0D9SEQ1_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 432 | Annotation score: | ||
A0A0D9SFX4 | A0A0D9SFX4_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 268 | Annotation score: | ||
A0A1B0GUD1 | A0A1B0GUD1_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 556 | Annotation score: | ||
A0A1B0GVZ8 | A0A1B0GVZ8_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 543 | Annotation score: | ||
A0A0C4DGF8 | A0A0C4DGF8_HUMAN | Histone-lysine N-methyltransferase ... | EHMT1 | 803 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL365502 Genomic DNA No translation available. AL590627 Genomic DNA No translation available. AL611925 Genomic DNA No translation available. |
RefSeqi | XP_005266167.1, XM_005266110.1 XP_011517327.1, XM_011519025.1 |
Genome annotation databases
Ensembli | ENST00000637161; ENSP00000490328; ENSG00000181090 |
GeneIDi | 79813 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL365502 Genomic DNA No translation available. AL590627 Genomic DNA No translation available. AL611925 Genomic DNA No translation available. |
RefSeqi | XP_005266167.1, XM_005266110.1 XP_011517327.1, XM_011519025.1 |
3D structure databases
SMRi | A0A1B0GV09 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1B0GV09 |
Protocols and materials databases
Antibodypediai | 32511, 514 antibodies from 31 providers |
DNASUi | 79813 |
Genome annotation databases
Ensembli | ENST00000637161; ENSP00000490328; ENSG00000181090 |
GeneIDi | 79813 |
Organism-specific databases
CTDi | 79813 |
HGNCi | HGNC:24650, EHMT1 |
OpenTargetsi | ENSG00000181090 |
VEuPathDBi | HostDB:ENSG00000181090 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156002 |
OrthoDBi | 753093at2759 |
PhylomeDBi | A0A1B0GV09 |
Miscellaneous databases
BioGRID-ORCSi | 79813, 58 hits in 1056 CRISPR screens |
ChiTaRSi | EHMT1, human |
GenomeRNAii | 79813 |
Gene expression databases
ExpressionAtlasi | A0A1B0GV09, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR038035, EHMT1 IPR043550, EHMT1/EHMT2 IPR007728, Pre-SET_dom IPR001214, SET_dom |
PANTHERi | PTHR46307, PTHR46307, 1 hit PTHR46307:SF2, PTHR46307:SF2, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF13637, Ank_4, 1 hit PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 7 hits SM00468, PreSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 5 hits PS50867, PRE_SET, 1 hit PS50280, SET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1B0GV09_HUMAN | |
Accessioni | A0A1B0GV09Primary (citable) accession number: A0A1B0GV09 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2016 |
Last sequence update: | October 5, 2016 | |
Last modified: | January 19, 2022 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |