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Entry version 18 (08 May 2019)
Sequence version 1 (05 Oct 2016)
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Protein

Uncharacterized protein SPEM3

Gene

SPEM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein SPEM3Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPEM3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:53651 SPEM3

neXtProt; the human protein knowledge platform

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neXtProti
NX_A0A1B0GUW6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 47HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENSG00000283439

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004434461 – 1196Uncharacterized protein SPEM3Add BLAST1196

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A0A1B0GUW6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000164517

Identification of Orthologs from Complete Genome Data

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OMAi
HLDSWIP

Database of Orthologous Groups

More...
OrthoDBi
129456at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031368 SPEM1_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15670 Spem1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1B0GUW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGERAYHGAQ VCSGTNPRKC QDLGDSILLL LGSFILLNVW INVVTLLWKH
60 70 80 90 100
LKSSLRILFR HFFPKDKQPS GSHPICICSS VDPKNLCSKV SSRVHPRPGF
110 120 130 140 150
LLRRVNHLDS WIPDTNDEKV SACCCVPPKC GHAGVPRESA RGLYKAGMMG
160 170 180 190 200
GGEAPQVTAS KAQASLLSRP ETSSQFPKMS KLDTGPCHLP QESKTKTPDC
210 220 230 240 250
APAEAPAQAQ VHSPTHTPVC TPTHPWTRST DHTAVHTPAH SWTHSKARTP
260 270 280 290 300
EGTHSQAQDT SAQAQAHTSA PTPAQTPAHI QAHTPAPTPA KASAHTKAHT
310 320 330 340 350
SAQAQTHSPP HTPEYTHSQA HSPEHTSAHS PAQAPMPVPA HPQAHAPEYT
360 370 380 390 400
SAHAPAYIPD HSHLVRSSVP VPTSAPAPPG TLAPATTPVL APTPAPVPAS
410 420 430 440 450
APSPAPALVM ALTTTPVPDP VPATTPAPII TPIPSTPPAF SHDLSTGHVV
460 470 480 490 500
YDARREKQNF FHMSSPQNPE YSRKDLATLF RPQEGQDLVS SGISEQTKQC
510 520 530 540 550
SGDSAKLPAG SILGYLELRN MEWKNSDDAK DKFPQTKTSP YCSFHPCSSE
560 570 580 590 600
KNTDSQAPFY PKFLAYSRDT ACAKTCFHSA TTAQSSVCTL PPPFTLSLPL
610 620 630 640 650
VPPRSFVPPQ PTNHQRPSTL IQTPTVLPTS KSPQSILTSQ FPIPSLFATI
660 670 680 690 700
SQPLIQPQCP ECHESLGLTQ DSGLQRTPGP SKDSRVPRNL DLAQNPDLYK
710 720 730 740 750
NPGLTQDPGL HENPGLAPNQ GLHEFPGLPQ DSYLCQNPSP SQDFGLHKNS
760 770 780 790 800
GITQDSHPQK NTGLTQEAGI LRSPCLTQSP GLHKKTPFTQ TSDLQRSSGF
810 820 830 840 850
TQDSGIYRNL EPNQETVIYK NQDLSQATDH QKNLGSSKDS GGHKNTGNVQ
860 870 880 890 900
DPGVCSTAGL TEDSGSQKGP YVPQDSEVNK SSGVIQESFL HKSPGLVQTS
910 920 930 940 950
GLPKCSGLTQ NSGDYKNPGL IQDCGGHKVK GLTQDSNLPS LTQATKVERR
960 970 980 990 1000
FSLPQDVGVY RSSEHSQDSN LHKCPGINQD PGPHKDPALV QDSGLPKISG
1010 1020 1030 1040 1050
LTQESGPYKS SCLIPDPSLY KNPSPALGSD FVQLLSLLQT PKSTLSLMKS
1060 1070 1080 1090 1100
SVPEKAAQKE DAQRHVLWAR VQLNENSCPS KAQVVSNDLQ TFSEVPVLIE
1110 1120 1130 1140 1150
LQSSSWRAGS QHGAYRPVDT VPSGYQNYRQ MSMPTHINWK SHCPGPGTQA
1160 1170 1180 1190
GHVVFDARQR RLAVGKDKCE ALSPRRLHQE APSNSGKPSR SGDIRM
Length:1,196
Mass (Da):128,649
Last modified:October 5, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28F08BFB0F28AAF2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC113189 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_011507026.1, XM_011508724.2
XP_011522098.1, XM_011523796.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000636696; ENSP00000490274; ENSG00000283439
ENST00000640133; ENSP00000491037; ENSG00000284090

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107983988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113189 Genomic DNA No translation available.
RefSeqiXP_011507026.1, XM_011508724.2
XP_011522098.1, XM_011523796.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Polymorphism and mutation databases

BioMutaiENSG00000283439

Proteomic databases

jPOSTiA0A1B0GUW6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000636696; ENSP00000490274; ENSG00000283439
ENST00000640133; ENSP00000491037; ENSG00000284090
GeneIDi107983988

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
107983988

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPEM3
HGNCiHGNC:53651 SPEM3
neXtProtiNX_A0A1B0GUW6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000164517
OMAiHLDSWIP
OrthoDBi129456at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A0A1B0GUW6

Family and domain databases

InterProiView protein in InterPro
IPR031368 SPEM1_N
PfamiView protein in Pfam
PF15670 Spem1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1B0GUW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: October 5, 2016
Last modified: May 8, 2019
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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