UniProtKB - A0A1B0GUB2 (A0A1B0GUB2_HUMAN)
Protein
Submitted name:
Parafibromin
Gene
CDC73
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- histone modification Source: InterPro
- transcription elongation from RNA polymerase II promoter Source: InterPro
Keywordsi
Biological process | TranscriptionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: ParafibrominImported |
Gene namesi | Name:CDC73Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16783, CDC73 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- Cdc73/Paf1 complex Source: InterPro
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 244 | CDC73_NInterPro annotationAdd BLAST | 244 | |
Domaini | 277 – 439 | CDC73_CInterPro annotationAdd BLAST | 163 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 238 – 277 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 238 – 259 | PolarSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the CDC73 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000001114 |
Family and domain databases
Gene3Di | 3.40.50.11990, 1 hit |
InterProi | View protein in InterPro IPR007852, Cdc73/Parafibromin IPR031336, CDC73_C IPR038103, CDC73_C_sf IPR032041, Cdc73_N |
PANTHERi | PTHR12466, PTHR12466, 1 hit |
Pfami | View protein in Pfam PF05179, CDC73_C, 1 hit PF16050, CDC73_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
A0A1B0GUB2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ
60 70 80 90 100
PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG
110 120 130 140 150
EASTSASIDR SAPLEIGLQR STQVKRAADE VLAEAKKPRI EDEECVRLDK
160 170 180 190 200
ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD
210 220 230 240 250
LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKEGASARK
260 270 280 290 300
TQTPAAQPVP RPVSQARPPP NQKKGSRTPI IIIPAATTSL ITMLNAKDLL
310 320 330 340 350
QDLKFVPSDE KKKQGCQREN ETLIQRRKDQ MQPGGTAISV TVPYRVVDQP
360 370 380 390 400
LKLMPQDWDR VVAVFVQGPA WQFKGWPWLL PDGSPVDIFA KIKAFHLKYD
410 420 430 440 450
EVRLDPNVQK WDVTVLELSY HKRHLDRPVF LRFWETLDRY MVKHKSHLRF
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6P1J9 | CDC73_HUMAN | Parafibromin | CDC73 C1orf28, HRPT2 | 531 | Annotation score: | ||
A0A3B3IRP5 | A0A3B3IRP5_HUMAN | Parafibromin | CDC73 | 482 | Annotation score: | ||
A0A2R8YHB3 | A0A2R8YHB3_HUMAN | Parafibromin | CDC73 | 385 | Annotation score: | ||
A0A2R8Y640 | A0A2R8Y640_HUMAN | Parafibromin | CDC73 | 197 | Annotation score: | ||
A0A3B3ISN2 | A0A3B3ISN2_HUMAN | Parafibromin | CDC73 | 104 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139133 Genomic DNA No translation available. AL390863 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000635846; ENSP00000490035; ENSG00000134371 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139133 Genomic DNA No translation available. AL390863 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A1B0GUB2 |
Protocols and materials databases
Antibodypediai | 4286, 253 antibodies |
Genome annotation databases
Ensembli | ENST00000635846; ENSP00000490035; ENSG00000134371 |
Organism-specific databases
HGNCi | HGNC:16783, CDC73 |
OpenTargetsi | ENSG00000134371 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000001114 |
Miscellaneous databases
ChiTaRSi | CDC73, human |
Gene expression databases
ExpressionAtlasi | A0A1B0GUB2, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.11990, 1 hit |
InterProi | View protein in InterPro IPR007852, Cdc73/Parafibromin IPR031336, CDC73_C IPR038103, CDC73_C_sf IPR032041, Cdc73_N |
PANTHERi | PTHR12466, PTHR12466, 1 hit |
Pfami | View protein in Pfam PF05179, CDC73_C, 1 hit PF16050, CDC73_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1B0GUB2_HUMAN | |
Accessioni | A0A1B0GUB2Primary (citable) accession number: A0A1B0GUB2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2016 |
Last sequence update: | October 5, 2016 | |
Last modified: | October 7, 2020 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |