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Entry version 16 (29 Sep 2021)
Sequence version 1 (05 Oct 2016)
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Protein
Submitted name:

Cilia- and flagella-associated protein 54

Gene

CFAP54

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cilia- and flagella-associated protein 54Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP54Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26456, CFAP54

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000188596

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000188596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A1B0GU80

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A1B0GU80, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1243 – 1263Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162446

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A1B0GU80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XSDIKIKEEN LFCDNIKGNE IFPSQQIARL IECERVLVAL ELSNFLNDSS
60 70 80 90 100
YALQAVTQCY GLLAPIIYHN IVLVPVVQIL IKCIVVLQGL PSIVCSKKHT
110 120 130 140 150
ASFESIQHMI ACCIFYITKI LRSWREYDLA VMIINYGKKM LDITPGCKSL
160 170 180 190 200
FDGSNEQEEM PEEDSSKKSL KTKKPQQILL PEKINEQLAL LETHLLKLTK
210 220 230 240 250
QYVTSELSGG EDPIFLYPVV LNWSVKGAVK EVMKFKQKPR FLEFFTQVML
260 270 280 290 300
KCMNEEKFHL MVEVTTPVHD FLKRRNESLL GLIKVKYKDS ALNKKANKSL
310 320 330 340 350
KFKAAVMEIG RSAEMQQRIR SKKKETLRDF IFKNPAISEM VAHERNRRTS
360 370 380 390 400
VRKAAQRYLM DYLNPLILSY VKRKRFHRLS LEEMPWRAQM NLYLAGAHFN
410 420 430 440 450
LVLQKLWECT KMKFGTSHMM VSFRSCDPNM FSLYNSGTVL PTRKLTVENY
460 470 480 490 500
KAMLDFLLTA KKRKANLPSD AEEFSTFINS IMSDENMSKT QTVYDSDSQS
510 520 530 540 550
GSSAKEKDRG ANLCVMDHFM KIFLYCRRAM VLAHRGGYWT LLQNCCRALW
560 570 580 590 600
NFTQELQILL KQAVDLDKTF PISQDGFLCT SVLPFYLGAE LLIDMLIQLQ
610 620 630 640 650
NTSSIKPIED KGEFSVPSCY GNIKNDNGGS SLTFEHPLDD VNVVDLKWIH
660 670 680 690 700
DFVLKSLEVL YQVEKWETLV SLAIQFNTVS HERYTEQVTP LLVYAQRQLL
710 720 730 740 750
LRIQKFKGPD ITQQPCARYE AEYGEKITCR NFIGKQLKIN SSTIEATSNC
760 770 780 790 800
TDLLKMLISS EYSRAKALVC VPVDVTDTLR CFRETLEKSK YHNRSIRHSR
810 820 830 840 850
KLLSLFLAQT QGEKGEINDS KCTSGKVEFC LGTEEMHMSI PPDLSQEHFR
860 870 880 890 900
VFSSVEKSKL PYSQLGLVIS SYHQTIDVLQ ASNQRSLKVQ ALHSLGSLLI
910 920 930 940 950
FAEKKRAAFK CWCQALDDIF RKPDVLHTWK EFGPSLTNVT NSHSPPGFKD
960 970 980 990 1000
YSEEFLSRVG IWGCLQGAVI SAKIAQFIKS LNVEKKTDCC ILSALLFQGL
1010 1020 1030 1040 1050
LRTTLPHPKA ERCYAQYEIT QLLPGIELFS DRYRADICSV IASLYYIIRE
1060 1070 1080 1090 1100
LHFVRQNLIV LPLLALYQYF VSGICQDITR NLEARILKIE VLIDLRFFSE
1110 1120 1130 1140 1150
AFYEISQIFY GKNMPCPIPA GYKATGKMKI FQSFDSGKLL TSKENIQAID
1160 1170 1180 1190 1200
ELRNKGLPAV LVTIGQPHLL NKFNFVKAYF FLSVAATINC VPENKFKTVI
1210 1220 1230 1240 1250
TNKSKPNLPN LEEIYSKDDG SSFYNLTKLK DEITLSMLKS MLLMEAEDRL
1260 1270 1280 1290 1300
NFLLSEVEQK TLSQCSAGEL EIVVEARLQL AAVALQRHRA AYSAAIVFST
1310 1320 1330 1340 1350
LTLLQDSKLF EKKVVQDDTE NPVSPGTSVT ENKDDSEFLD PISLNAREYF
1360 1370 1380 1390 1400
NIHLWLRCRL ALVTAFVAQI HGIGIVKEDD MTDCLSLINE VCMEAKSAGD
1410 1420 1430 1440 1450
TELQAEFLTQ AVILGLQEKH LKADIMTNLQ DIIHLLEGNE FISPQSRLTL
1460 1470 1480 1490 1500
ARSLVLLDDL TKAEKFKESP SSKTGKLNLL TRAHSILTEQ MLAFGETIEF
1510 1520 1530 1540 1550
RSSNTKYANP LQPLKNIYLP HVMLLAKIKM RIGHTVAKQV YYKNKRKDPS
1560 1570 1580 1590 1600
KWLPALHLFD VALKLCRTTA VEEHEVEAEI LFQKGKIERQ ILMEEKSPSF
1610 1620 1630 1640 1650
QLESLYEAIQ LSLKNDQNSG LIRDSYLEMA LLYFHLKKPK IKISGSPLTL
1660 1670 1680 1690 1700
KPPLRRSSSV KETSANKFEM YSSLAWIAIR AAAQVSEAVL AINLLIGKKN
1710 1720 1730 1740 1750
TRMHKVNQVA LPNIPEFAAL DLLSSYTDYL LDNYQVLFQT SCTFLYQNDD
1760 1770 1780 1790 1800
VCDSADGRKK TQTKVDITWI LLLRYYIHLQ RINNLSKLLA SATPVSGISL
1810 1820 1830 1840 1850
PDDTLLTSLY NSELILRQKE VHFFLKKFLQ LYSSSCIDEF PKELLCQLEN
1860 1870 1880 1890 1900
PPLSEKDLRE SSAKLYRDSS VQSILSFKPV SGSSCVDITP IEMVTQASNK
1910 1920 1930 1940 1950
ELCFQWYIPP LDRPPKETEP MVLLLYAYNL KPLKISDVRH STYNSTCVGS
1960 1970 1980 1990 2000
LWIPLNRVIA IHEKLSNLAQ IAELSLPAAP EITSNENIYE VEVEEESVDN
2010 2020 2030 2040 2050
EMEDMIIQCC SEIASLFLND KEPTPLSEVP FDISLPSIFN LERLFDLANG
2060
CILSGGSLFN WIVSIIP
Length:2,067
Mass (Da):235,376
Last modified:October 5, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2518402338C434B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96N23CFA54_HUMAN
Cilia- and flagella-associated prot...
CFAP54 C12orf55, C12orf63
3,096Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTQ3A0A0A0MTQ3_HUMAN
Cilia- and flagella-associated prot...
CFAP54
644Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIB5H0YIB5_HUMAN
Cilia- and flagella-associated prot...
CFAP54
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007513 Genomic DNA No translation available.
AC007564 Genomic DNA No translation available.
AC008118 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000637336; ENSP00000490000; ENSG00000188596

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007513 Genomic DNA No translation available.
AC007564 Genomic DNA No translation available.
AC008118 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

PeptideAtlasiA0A1B0GU80

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50190, 5 antibodies

Genome annotation databases

EnsembliENST00000637336; ENSP00000490000; ENSG00000188596

Organism-specific databases

HGNCiHGNC:26456, CFAP54
OpenTargetsiENSG00000188596
VEuPathDBiHostDB:ENSG00000188596

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000162446

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CFAP54, human

Gene expression databases

ExpressionAtlasiA0A1B0GU80, baseline and differential

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1B0GU80_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1B0GU80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: September 29, 2021
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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