UniProtKB - A0A1B0GSE5 (A0A1B0GSE5_MOUSE)
Protein
Deubiquitinating enzyme CYLD
Gene
Cyld
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: InterPro
GO - Biological processi
- innate immune response Source: UniProtKB-KW
- protein deubiquitination Source: InterPro
- ubiquitin-dependent protein catabolic process Source: InterPro
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Biological process | Immunity, Innate immunityARBA annotation, Ubl conjugation pathwayARBA annotation, Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Deubiquitinating enzyme CYLDARBA annotationAlternative name(s): Ubiquitin carboxyl-terminal hydrolase CYLDARBA annotation Ubiquitin thioesterase CYLDARBA annotation Ubiquitin-specific-processing protease CYLDARBA annotation |
Gene namesi | Name:CyldImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921506, Cyld |
Subcellular locationi
Cytoskeleton
- cilium basal body ARBA annotation
- centrosome ARBA annotation
- spindle ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- perinuclear region ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
- spindle Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, MembranePTM / Processingi
Keywords - PTMi
Ubl conjugationARBA annotationProteomic databases
ProteomicsDBi | 373310 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 198 | CAP-GlyInterPro annotationAdd BLAST | 46 | |
Domaini | 406 – 764 | USPInterPro annotationAdd BLAST | 359 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 311 – 348 | DisorderedSequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 325 – 348 | PolarSequence analysisAdd BLAST | 24 |
Phylogenomic databases
GeneTreei | ENSGT00390000018123 |
Family and domain databases
Gene3Di | 2.30.30.190, 2 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF01302, CAP_GLY, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 2 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF74924, SSF74924, 2 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 1 hit PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A1B0GSE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI
60 70 80 90 100
QDRSVGHSRV PSTKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL
110 120 130 140 150
LAITNCEERL SLFRNRLRLS KGLQVDVGSP VKVQLRSGEE KFPGVVRFRG
160 170 180 190 200
PLLAERTVSG IFFGVELLEE GRGQGFTDGV YQGKQLFQCD EDCGVFVALD
210 220 230 240 250
KLELIEDDDN GLESDFAGPG DTMQVEPPPL EINSRVSLKV GESTESGTVI
260 270 280 290 300
FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAS VESTILLHIN
310 320 330 340 350
DIIPDSVTQE RRPPKLAFMS RGVGDKGSSS HNKPKVTGST SDPGSRNRSE
360 370 380 390 400
LFYTLNGSSV DSQQSKSKNP WYIDEAFGGY LSEVVEENTP PKMEKEGLEI
410 420 430 440 450
MIGKKKGIQG HYNSCYLDST LFCLFAFSSA LDTVLLRPKE KNDIEYYSET
460 470 480 490 500
QELLRTEIVN PLRIYGYVCA TKIMKLRKIL EKVEAASGFT SEEKDPEEFL
510 520 530 540 550
NILFHDILRV EPLLKIRSAG QKVQDCNFYQ IFMEKNEKVG VPTIQQLLEW
560 570 580 590 600
SFINSNLKFA EAPSCLIIQM PRFGKDFKLF KKIFPSLELN ITDLLEDTPR
610 620 630 640 650
QCRICGGLAM YECRECYDDP DISAGKIKQF CKTCSTQVHL HPRRLNHSYH
660 670 680 690 700
PVSLPKDLPD WDWRHGCIPC QKMELFAVLC IETSHYVAFV KYGKDDSAWL
710 720 730 740 750
FFDSMADRDG GQNGFNIPQV TPCPEVGEYL KMSLEDLHSL DSRRIQGCAR
760 770
RLLCDAYMCM YQSPTMSLYK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ80TQ2 | CYLD_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Cyld Cyld1, Kiaa0849 | 952 | Annotation score: | ||
Z4YJJ5 | Z4YJJ5_MOUSE | Deubiquitinating enzyme CYLD | Cyld | 955 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC138025 Genomic DNA No translation available. AC156937 Genomic DNA No translation available. |
RefSeqi | NP_001263208.1, NM_001276279.1 XP_006531483.1, XM_006531420.1 |
Genome annotation databases
Ensembli | ENSMUST00000209206; ENSMUSP00000147904; ENSMUSG00000036712 |
GeneIDi | 74256 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC138025 Genomic DNA No translation available. AC156937 Genomic DNA No translation available. |
RefSeqi | NP_001263208.1, NM_001276279.1 XP_006531483.1, XM_006531420.1 |
3D structure databases
SMRi | A0A1B0GSE5 |
ModBasei | Search... |
Proteomic databases
ProteomicsDBi | 373310 |
Protocols and materials databases
Antibodypediai | 3193, 306 antibodies |
DNASUi | 74256 |
Genome annotation databases
Ensembli | ENSMUST00000209206; ENSMUSP00000147904; ENSMUSG00000036712 |
GeneIDi | 74256 |
Organism-specific databases
CTDi | 1540 |
MGIi | MGI:1921506, Cyld |
Phylogenomic databases
GeneTreei | ENSGT00390000018123 |
Miscellaneous databases
BioGRID-ORCSi | 74256, 3 hits in 54 CRISPR screens |
ChiTaRSi | Cyld, mouse |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | A0A1B0GSE5, baseline and differential |
Family and domain databases
Gene3Di | 2.30.30.190, 2 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF01302, CAP_GLY, 1 hit PF00443, UCH, 1 hit |
SMARTi | View protein in SMART SM01052, CAP_GLY, 2 hits |
SUPFAMi | SSF54001, SSF54001, 1 hit SSF74924, SSF74924, 2 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 1 hit PS50245, CAP_GLY_2, 1 hit PS00972, USP_1, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1B0GSE5_MOUSE | |
Accessioni | A0A1B0GSE5Primary (citable) accession number: A0A1B0GSE5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 5, 2016 |
Last sequence update: | October 5, 2016 | |
Last modified: | April 7, 2021 | |
This is version 26 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |