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Protein

Neuropilin

Gene

NRP1A

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi193CalciumUniRule annotation1
Metal bindingi207CalciumUniRule annotation1
Metal bindingi248CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, ReceptorUniRule annotation
Biological processDifferentiationUniRule annotation, NeurogenesisUniRule annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuropilinUniRule annotation
Gene namesi
Name:NRP1AImported
OrganismiNothobranchius furzeri (Turquoise killifish)Imported
Taxonomic identifieri105023 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei851 – 876HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500838048020 – 917NeuropilinSequence analysisAdd BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 52UniRule annotation
Disulfide bondi80 ↔ 102UniRule annotation
Disulfide bondi145 ↔ 171UniRule annotation
Disulfide bondi204 ↔ 226UniRule annotation
Disulfide bondi273 ↔ 422UniRule annotation
Disulfide bondi429 ↔ 581UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 139CUBInterPro annotationAdd BLAST115
Domaini145 – 263CUBInterPro annotationAdd BLAST119
Domaini273 – 422F5/8 type CInterPro annotationAdd BLAST150
Domaini429 – 581F5/8 type CInterPro annotationAdd BLAST153
Domaini636 – 805MAMInterPro annotationAdd BLAST170

Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd00041 CUB, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF1 PTHR44185:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 1 hit
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A8VER8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCGLVLILF MGFLLVVKAF KNDKCGGNIR ISSASYLTSP GYPMSYPPSQ
60 70 80 90 100
RCAWVISAPG PHQRILINFN PHFDLEDREC KYDYVEVRDG VDENGQLVGK
110 120 130 140 150
YCGKIAPSPV ISSGNQLFIK FVSDYETHGA GFSIRYEIFK TGPECSRNFT
160 170 180 190 200
SNSGVIKSPG FPEKYPNNLD CTFMIFAPKM SEIIVEFESF ELEPDTTPPT
210 220 230 240 250
GVFCRYDRVE IWDGFPGVGP YIGRYCGQNT PGRIISYTGI LALTINTDSA
260 270 280 290 300
IAKEGFSANF TVIERTVPED FDCSDPLGME SGEITSDQIM ASSQYNPSWS
310 320 330 340 350
PERSRLNYYE NAWTPAEDSN KEWIQVDLGF LRFVSAIGTQ GAISQETRKI
360 370 380 390 400
YFVKSYKVDV SSNGEDWITL KEGSKQKVFQ GNTNPTEITK TKLPKPTMTR
410 420 430 440 450
FIRVRPVTWE TGIALRFEVY GCKISEYPCS GMLGMVSGLI SDNQITASSH
460 470 480 490 500
SDRNWVPENA RLLTSRTGWT LLPQPQPFTN EWLQVDFGEE KLVKGLIIQG
510 520 530 540 550
GKHRENKVFM KKFRFGYSNN GSDWKMVYDT NTNKPKVFEG NSNYDTPELR
560 570 580 590 600
TVEPLLTRFV RIYPERATPA GMGLRLELLG CEIDAPTLPP TTLVTSTTPS
610 620 630 640 650
DECDDDQASC HSGTGGAMTT ETTPSEADTI PAFLWFACDF GWANDPSFCS
660 670 680 690 700
WTSEDTGSRW QIQSSGTPTL NTGPNMDHMG GSGNFIYTLA TGLQETEVAR
710 720 730 740 750
LVSPVVSSPD SDLCVSFWYH MFGSHIGTLH IKQRKQTETG PVDILLWTVS
760 770 780 790 800
GHQGNRWREG RVLVPRTNKP YQVVIEGLVE RKSWGDIAVD DIKVLNGLSI
810 820 830 840 850
SDCEDPDVPT EPMLPEDRFN EIFEEITEYP DFVETNQISG TGNMLKTLDP
860 870 880 890 900
ILITIIAMSA LGVFLGAICG VVLYCACSHG GISERNLSAL ENYNFELVDG
910
VKLKKDKLNV QSSYSEA
Length:917
Mass (Da):102,106
Last modified:October 5, 2016 - v1
Checksum:iAD9A834147A97FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HAEJ01018458 Transcribed RNA Translation: SBS58915.1
RefSeqiXP_015810368.1, XM_015954882.1

Genome annotation databases

GeneIDi107382650

Similar proteinsi

Entry informationi

Entry nameiA0A1A8VER8_NOTFU
AccessioniPrimary (citable) accession number: A0A1A8VER8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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