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Entry version 24 (16 Jan 2019)
Sequence version 1 (05 Oct 2016)
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Protein
Submitted name:

Collagen, type IV, alpha 1

Gene

COL4A1

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type IV, alpha 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL4A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNothobranchius furzeri (Turquoise killifish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri105023 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501505925125 – 1637Sequence analysisAdd BLAST1613

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1413 – 1637Collagen IV NC1InterPro annotationAdd BLAST225

Keywords - Domaini

CollagenSAAS annotationImported, SignalSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06237

Identification of Orthologs from Complete Genome Data

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OMAi
DPQCPPG

Database of Orthologous Groups

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OrthoDBi
63831at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1A8URG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFTRGALLL LLAALSSNLD LTGAEGCGTS CGKCDCSGVK GAKGERGFPG
60 70 80 90 100
LQGNMGFPGM QGHEGPPGPM GPKGDLGSPG APGLKGVRGP HGLPGMPGNP
110 120 130 140 150
GLPGINGNDG PPGSPGIPGC NGTKGERGRD GSPGFPGLQG PPGIPGYPGM
160 170 180 190 200
KGDPGGVMGI IPTKGDRGLP GLPGLPGSSG LQGPSGPAGP RGYPGPKGDI
210 220 230 240 250
GLPGPPGEKG DKLSFVSAKG EKGDQGLRGP PGPPGLPQGV EGQTTVLVPG
260 270 280 290 300
PQGYPGPPGD KGEKGFCLPY QIGVKGELGP PGPRGKPGKD GQDGLKGERG
310 320 330 340 350
FPGAPGFPGS DGVKGERGPP GYGSGPPGPP GPRGSPGSPG QKGFIGPQGE
360 370 380 390 400
AGPPGRHVEG PRGEKGLKGE VGEKGDRGID GEPLPGPPGK QGPIGPPGPP
410 420 430 440 450
GPSIDPKECN VAKGAPGAPG LPGLPGEDGQ KGDRGDACIT CEGSGPPGPQ
460 470 480 490 500
GIKGAQGPPG PAGSKGQKGN SGFPGEPGAP GFPGTAGLMG APGAVGDPGD
510 520 530 540 550
IFIAPGYKGE KGLPGFPGLQ GSQGLDGLPG RDGLPGLQGP KGEPAKEGIK
560 570 580 590 600
GDRGLDGDPG HSGPPGERGP PGLPGFSLPG DPGEKGSQGR PGTPGSPGPP
610 620 630 640 650
GVKGEPGVGV STPGPQGVPG PRGETGVPGL QGDRGVPGNP GLPGFPGEKG
660 670 680 690 700
QHGAPGIGLP GPTGSKGVSG IPGNTGIPGE PGRPGQDGLP GKAGPPGQKG
710 720 730 740 750
EPGRGLPGPK GTQGLQGVTG FPGEKGNIGL PGVPGPEGPT GAPGPQGLKG
760 770 780 790 800
DIGPPGRPGQ TGQPGAPGKG LPGPPGAQGP PGEPGPYGRE GLKGEKGYPG
810 820 830 840 850
LPGLDMPGPQ GEKGSSGFQG VPGAKGLPGS PGLPGRDGQF GSQGPKGEMG
860 870 880 890 900
IMGTPGTPGY PGPTGTPGSP GLRGDPGITG PRGAVGETGP KGDRGEDGLP
910 920 930 940 950
GPPGNLTKVD MEHLKGQKGD VGDPGQRGDT GLKGHIGVQG DPGMPGSDGA
960 970 980 990 1000
PGTPGKPGDK GSTGDPGEPG IIGQPGQKGS SGEMGIPGPV GPKGTKGDFG
1010 1020 1030 1040 1050
TPGHPGLRGA DGVKGDRGLP GEPGIGLPGQ PGQKGQVGQP GFPGLRGDKG
1060 1070 1080 1090 1100
EQGQEGMPGK PGLQGLKGDK GSIGHSGQPG RPGDKGYPGL PGSAGEPGQD
1110 1120 1130 1140 1150
GRPGEGGMQG PPGPRGDKGD PGEDGIPGST GERGEPGSPG VGLPGTPGVH
1160 1170 1180 1190 1200
GVKGDKGSPG LPGMSGQPGI PGTRGDKGLP GPEGLQGEPG EPGPQGISLE
1210 1220 1230 1240 1250
GPKGERGETG PVGETGSPGE PGPVGVPGRD GLKGGKGDSG LPGFQGEMGR
1260 1270 1280 1290 1300
KGDPGFPGIS GPPGLPGIDG QKGERGLQGV PGFPGTKGVV GDGGFKGELG
1310 1320 1330 1340 1350
DRGFPGEKGN EGPPGPPGSQ IFIKGEAGFP GIQGFPGPQG PSGLPGQKGQ
1360 1370 1380 1390 1400
QGMTGIPGPK GDHGLPGFNG QPGAKGEPGF PGPQGPRGDS GPPGPDGVPG
1410 1420 1430 1440 1450
QVGPPGPASM EHGFLVTRHS QTVDIPSCPY GTRIIYDGYS LLYVQGNERS
1460 1470 1480 1490 1500
HGQDLGTAGS CLRKFSPMPF LFCNINNVCN FASRNDYSYW LTSPEPMPMS
1510 1520 1530 1540 1550
MAPITGNSIK PFISRCVVCE APAMVIAVHS QTIMIPPCPE GWNSLWIGYS
1560 1570 1580 1590 1600
FVMHTSAGAE GSGQALASPG SCLEEFRSAP FIECHGRGTC NYYANSYSFW
1610 1620 1630
LATIEDDDMF KKPVPTTLKA GSLQTHISRC QVCMKRT
Length:1,637
Mass (Da):159,018
Last modified:October 5, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16F6D22D29561A2E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HADY01000998 Transcribed RNA Translation: SBP39483.1
HAEJ01009201 Transcribed RNA Translation: SBS49658.1

NCBI Reference Sequences

More...
RefSeqi
XP_015821741.1, XM_015966255.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
107389849

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nfu:107389849

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HADY01000998 Transcribed RNA Translation: SBP39483.1
HAEJ01009201 Transcribed RNA Translation: SBS49658.1
RefSeqiXP_015821741.1, XM_015966255.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107389849
KEGGinfu:107389849

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1282

Phylogenomic databases

KOiK06237
OMAiDPQCPPG
OrthoDBi63831at2759

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 18 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1A8URG4_NOTFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1A8URG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: January 16, 2019
This is version 24 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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