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Protein

DNA polymerase alpha subunit B

Gene

POLA2

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase alpha subunit BUniRule annotation
Gene namesi
Name:POLA2Imported
OrganismiNothobranchius furzeri (Turquoise killifish)Imported
Taxonomic identifieri105023 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 243Pol_alpha_B_NInterPro annotationAdd BLAST220
Domaini348 – 554DNA_pol_E_BInterPro annotationAdd BLAST207

Sequence similaritiesi

Belongs to the DNA polymerase alpha subunit B family.UniRule annotation

Phylogenomic databases

KOiK02321

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A8B277-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQVTAESLK EEMEMFSVSY EDDAVLDKMV EQCICNRLEA NEMVNEWVAF
60 70 80 90 100
SSTKKGLKLT INTLQQFEHE VLNKRSQSKP SSRKDEAYNR PMDIHTIQEL
110 120 130 140 150
IKAEEEEEDL LDSYSTPAKG SQKRALTTPE HPRSKRSAAL LPSPSLLLSP
160 170 180 190 200
ASFSPSATPS QKYSQRGAKG EVVVTFGAVQ GTRWVGRKDP GAGVQVELLE
210 220 230 240 250
GPENSLCCSY KFMFQRLRDV HNVLAEKIED LGKSLISHFK IEELSCASLP
260 270 280 290 300
AQDTISVLGQ VCCDGNGKLN AKSVLLEAGP DQGGQQVPVD LSELKEYSLF
310 320 330 340 350
PGQVVVMEGM NATGERFVAS KLYDGVPLPF YTSNVKTEND EVSEPLSVLV
360 370 380 390 400
ACGPYMPSDS LTFDPLLDLI SVIVRDRPDV CLLLGPFVDS KHEKIEKAEV
410 420 430 440 450
TETFEAIFSR CIESIVDGTR SVGCHLVFVP SQRDIHHHFI YPQPPFTLPS
460 470 480 490 500
LRKEQIQRVT LVSDPCTLLI NGVTFGLTST DILFHISAEE ISSGTGSDRF
510 520 530 540 550
SRILKHMLTQ RSYYPLYPPV EEVNMDYEKF QSFGQMPLTP DVLIIPSELR
560 570 580 590 600
YFVKDVVGCV CVNPGRLTKG QVGGTYSRML LQHGASSEVG QRVSPCLAAQ

VVKI
Length:604
Mass (Da):66,913
Last modified:October 5, 2016 - v1
Checksum:iA7416818031BFFC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HADY01022100 Transcribed RNA Translation: SBP60585.1
RefSeqiXP_015802271.1, XM_015946785.1

Genome annotation databases

GeneIDi107377270
KEGGinfu:107377270

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HADY01022100 Transcribed RNA Translation: SBP60585.1
RefSeqiXP_015802271.1, XM_015946785.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107377270
KEGGinfu:107377270

Organism-specific databases

CTDi23649

Phylogenomic databases

KOiK02321

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1A8B277_NOTFU
AccessioniPrimary (citable) accession number: A0A1A8B277
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: February 28, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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