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Entry version 9 (31 Jul 2019)
Sequence version 1 (05 Oct 2016)
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Protein
Submitted name:

MAP-kinase activating death domain

Gene

MADD

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MAP-kinase activating death domainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MADDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNothobranchius furzeri (Turquoise killifish)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri105023 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 577UDENNInterPro annotationAdd BLAST565

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 182DisorderedSequence analysisAdd BLAST78
Regioni617 – 649DisorderedSequence analysisAdd BLAST33
Regioni685 – 719DisorderedSequence analysisAdd BLAST35
Regioni766 – 847DisorderedSequence analysisAdd BLAST82
Regioni881 – 926DisorderedSequence analysisAdd BLAST46
Regioni1038 – 1071DisorderedSequence analysisAdd BLAST34
Regioni1106 – 1198DisorderedSequence analysisAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili969 – 989Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi114 – 139PolarSequence analysisAdd BLAST26
Compositional biasi165 – 182PolarSequence analysisAdd BLAST18
Compositional biasi696 – 719PolarSequence analysisAdd BLAST24
Compositional biasi798 – 815PolarSequence analysisAdd BLAST18
Compositional biasi830 – 847PolarSequence analysisAdd BLAST18
Compositional biasi905 – 926PolarSequence analysisAdd BLAST22
Compositional biasi1130 – 1186PolarSequence analysisAdd BLAST57

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13008 PTHR13008, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1A8B0A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKKICPRL LDYLVVVGAR QPSSDSVAQT PQLLRRYPLD DHHDFPLPPD
60 70 80 90 100
VVFFCQPEGC LSIRQRRVSL RDDSSFVFTL TDKDSGITRY GICVNFYRSF
110 120 130 140 150
QRGHHRTRVD KSSHTETTAQ AAETANDVSD GSSGGEPTVV SAPINCESAL
160 170 180 190 200
PPVSEEEGGQ PDVEQISGKS PQQRRSGAKV AARNRNSTLT SLCILSHYPF
210 220 230 240 250
FTTFRECLYI LKRLVDCCSQ RLTQRVGLPR ATQRDTMWRV FTGALSVEEK
260 270 280 290 300
GSQLLADLRE IESWVYRLLR SPVAVAGQRR VDVEVLPHEL KRPLTFALPD
310 320 330 340 350
NSRFSLVDFP LHLPLELLGV DACLQVLSCV LLEHKVILQS RDYNALSMSV
360 370 380 390 400
MAFVAMIYPL EYMFPVIPLL PTCMASAEQL LLAPTPYIIG VPASFFLYKS
410 420 430 440 450
DFKMPDDVWL VDLDSSKVIA PTNAEILPPL PEPEAGELKK HLKQALASMS
460 470 480 490 500
LNTQPILNLE KFQEGQEIAL LPPGRDKASP SSTEFNPLIY GNDVDSVDVA
510 520 530 540 550
TRVAMVRFFN SPNVLQGFQM HTRTLRLFPR PVVAFQSSSF LASRPRRSGF
560 570 580 590 600
ADKLSHTQAV EFFGEWALNP TNLAFQRIHN NVYDPSLIGD KPKWYAHQLQ
610 620 630 640 650
PVVYRVYDGS SQLVEAMSSP LEDEGNESDP TDSGSDSEGY DDSSSSYSSL
660 670 680 690 700
GDLVSEMIQG DIQGDTPSLD PPTHAALGDA SEAFQDAEDP TSGDGAVETS
710 720 730 740 750
DGQTLRSSSS TTASSSPSTI IQGVNHEQGE APEIEASASA ALQNPVPGLS
760 770 780 790 800
SQPFLRHVAD TGLVDPVNKK QEYDNPYFEP QYGFPSEDDP EAEEQVESYT
810 820 830 840 850
PRFNQNLNGN KAQRPLRPSS LRLLGESDGE GDSRNSSPNS TISNSSNDGF
860 870 880 890 900
GGLMSFASNL YKNHGTSFSL SNLALPNKAA REKSTPFPSL KGARAPRALV
910 920 930 940 950
DQKSSVIKHS PTVKRESPSP QGRVNNTSEN QQFLKEVVQS VLDGQGVGWL
960 970 980 990 1000
NMKKVRRLLE NEQLRVFVLS KLNRAIQSEE DARQEIIRDV EVNRKVYKGM
1010 1020 1030 1040 1050
LDILKCTVSS LEHSYTNAGL GGMASVFSLL EIARTHYQTK DPEKRKRSPT
1060 1070 1080 1090 1100
DSAGSPGSKE SPSGRMEVPR PQGLLNIPQL QLPHHTTGKG ARHFDTRSLN
1110 1120 1130 1140 1150
EENFIASIGS EGTKQQRPQV ADAEEKKSQI SADSGLSVAS GSQKSDTDSV
1160 1170 1180 1190 1200
TSSGPPILTR STSQDSEAST VISNSSGETL GADSDLSSTA GDGLGGRTAL
1210 1220 1230 1240 1250
HLTQSRGTLS DSEIETNPAT SSVFAKTHTL KAGAKEQVAA MVKGPPAQPM
1260 1270 1280 1290 1300
EDISMRIYLF EGLLGRDKSS VWDQLEDAAM ETFSLSKERS TLWDQLQFWE
1310 1320 1330 1340 1350
DAFLDAVMLE REGMGMDQGP QEMIERYLSL GEHDRKRLED DEDRLLATLL
1360 1370 1380 1390 1400
HNMIAYMLMM KVTKNDIRKK VRRLMGKSHI GLTYSQEINE ILDKLPNMNG
1410 1420 1430 1440 1450
RELAIRPSGS RHIKKQTFVV HAGTDTTGDI FFMEVCDDCI VLRSNIGTVY
1460 1470 1480 1490 1500
ERWWYEKLIN MTYCPKTKVL CLWRRNGQET QLNKFYTKKC RELYYCVKDS
1510 1520 1530 1540 1550
MERAAARQQS IKPGPELGGE FPVQDMKTGE GGLLQVTLEG INLKFMHSQF

LKLKKW
Length:1,556
Mass (Da):172,365
Last modified:October 5, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EA939190A6B4F85
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
HADY01022214 Transcribed RNA Translation: SBP60699.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HADY01022214 Transcribed RNA Translation: SBP60699.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13008 PTHR13008, 1 hit
PfamiView protein in Pfam
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1A8B0A8_NOTFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1A8B0A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: July 31, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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