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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

FDXR

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42FAD; via amide nitrogenUniRule annotation1
Binding sitei63FADUniRule annotation1
Binding sitei71FAD; via amide nitrogenUniRule annotation1
Binding sitei107FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei234NADPUniRule annotation1
Binding sitei392FAD; via amide nitrogenUniRule annotation1
Binding sitei399NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 181NADPUniRule annotation4
Nucleotide bindingi222 – 223NADPUniRule annotation2
Nucleotide bindingi399 – 401FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:FDXRImported
OrganismiNothobranchius furzeri (Turquoise killifish)Imported
Taxonomic identifieri105023 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 189FAD/NAD-binding_domInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Phylogenomic databases

KOiK18914

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR021163 Ferredox_Rdtase_adrenod
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PIRSFiPIRSF000362 FNR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A8ABH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCKLLLSAV GRRRLHKGFA VCGKAFLSSG SPKVCIVGSG PAGFYTAQHL
60 70 80 90 100
LKAHQNVQVD VYERLPVPFG LVRFGVAPDH PEVKNVINTF TQTAKHPRCS
110 120 130 140 150
FYGNVNVGED VSVDELQEAY HAIVLSYGAE GNRSVGVPGE DLPGVYSAKD
160 170 180 190 200
FVGWYNGLPS CQELRPDLSC ETAVILGQGN VALDVARILL SPLDALKKTD
210 220 230 240 250
ITQPALEALA QSRVCRVLIV GRRGPMQVAS TIKELREMVN LPGTRPEMVA
260 270 280 290 300
ADFDGVAEAL KDLPRPRKRL TELMLKTALE MPTEKEQERR KKASRIWGFR
310 320 330 340 350
FFRSPVEILA EPGCNRVAGV RLAVNKLEGS GEKAQAVLTG EVEDVPCGLV
360 370 380 390 400
ISSIGYRSLP IDPTVPFDSR RAIVPNSMGR VHNAAGLYCS GWLKTGPTGV
410 420 430 440 450
IATTMNSSFD TARSLLEDVE SGKLDVSSAK PGSHMISSLL EKRGVKPVTF
460 470 480
SDWEKIDDLE TRRGEVSGKP REKILTVAAM LKVAQT
Length:486
Mass (Da):52,744
Last modified:October 5, 2016 - v1
Checksum:i608FFCDEA78F1B9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HADY01013543 Transcribed RNA Translation: SBP52028.1
HAEJ01017801 Transcribed RNA Translation: SBS58258.1
RefSeqiXP_015819225.1, XM_015963739.1

Genome annotation databases

GeneIDi107388287
KEGGinfu:107388287

Similar proteinsi

Entry informationi

Entry nameiA0A1A8ABH1_NOTFU
AccessioniPrimary (citable) accession number: A0A1A8ABH1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: April 25, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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