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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene

MED6

Organism
Nothobranchius furzeri (Turquoise killifish)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6UniRule annotation
Alternative name(s):
Mediator complex subunit 6UniRule annotation
Gene namesi
Name:MED6Imported
OrganismiNothobranchius furzeri (Turquoise killifish)Imported
Taxonomic identifieri105023 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesNothobranchiidaeNothobranchius

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the Mediator complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.UniRule annotation

Phylogenomic databases

KOiK15128

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A8A747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVASVDFRD NLLGISWVDS GWVPILNPGN VLDYFSERSN PFYDRTCNNE
60 70 80 90 100
VVKMQRLTLD HLNQMVGVEY ILLHAQEPIL YIIRKQQRQS SAHVIPLADY
110 120 130 140 150
YIIAGVVYQA PDLGTVISSR VLSAVHGIQS AFDEAISYCR YHPSKGYWWH
160 170 180 190 200
FKDQEEREKA KPKSKKKEEP SSLFQRQRVD TLLLDLRSKF PPTFYQPKPG
210 220 230 240
DKPIPVEVKK EPEPASDAVK QEEREPATKL SASAPPTKPP PEKRARLQ
Length:248
Mass (Da):28,357
Last modified:October 5, 2016 - v1
Checksum:i592EF62ECC54E2A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HADY01012018 Transcribed RNA Translation: SBP50503.1
HAEJ01001906 Transcribed RNA Translation: SBS42363.1
RefSeqiXP_015824695.1, XM_015969209.1

Genome annotation databases

GeneIDi107391759
KEGGinfu:107391759

Similar proteinsi

Entry informationi

Entry nameiA0A1A8A747_NOTFU
AccessioniPrimary (citable) accession number: A0A1A8A747
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: July 18, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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