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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium sp. 852013-50142_SCH4511227
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationImported, Transferase
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
ORF Names:A6B34_07960Imported
OrganismiMycobacterium sp. 852013-50142_SCH4511227Imported
Taxonomic identifieri1834110 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000093781 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1A0T955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGTTSNGAA PSGAGVAVVI AVKRLADAKT RLAPIFAPHD RETVVLAMLV
60 70 80 90 100
DTVAAAAAVA AVTVVTPDPA AAEAARALGA QVLDDPTPAG HPDPLNNALR
110 120 130 140 150
AAEAAVRATV PNVVALQGDL PALQTQELSE AIAAARTRPR SFVGDRHGTG
160 170 180 190 200
TSALFAFGVP LDPRFGPDSA ERHRRSGAVE LTGSWPGLRY DIDTPDDLLA
210
ARRLGVGTQT ARAVGAER
Length:218
Mass (Da):22,297
Last modified:October 5, 2016 - v1
Checksum:i445DCC248D33BCD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LZST01000193 Genomic DNA Translation: OBB55440.1
RefSeqiWP_064876059.1, NZ_LZST01000193.1

Genome annotation databases

EnsemblBacteriaiOBB55440; OBB55440; A6B34_07960

Similar proteinsi

Entry informationi

Entry nameiA0A1A0T955_9MYCO
AccessioniPrimary (citable) accession number: A0A1A0T955
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: December 20, 2017
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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