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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Bacillus subtilis subsp. subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi32ZincUniRule annotation1
Metal bindingi35ZincUniRule annotation1
Metal bindingi51ZincUniRule annotation1
Metal bindingi54ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri32 – 54C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
ORF Names:BH660_10255Imported
OrganismiBacillus subtilis subsp. subtilisImported
Taxonomic identifieri135461 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000095556 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A199WK19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri32 – 54C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

HAMAPiMF_01395 AcetylCoA_CT_beta, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR000438 Acetyl_CoA_COase_Trfase_b_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
PRINTSiPR01070 ACCCTRFRASEB
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00515 accD, 1 hit
PROSITEiView protein in PROSITE
PS50980 COA_CT_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A199WK19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKDIFTKKK KYASVPSDQA KHDVPEGIMT KCPKCKKIML TKELDKNMRV
60 70 80 90 100
CMNCDYHFPM NAKQRIESLM DEQSFEEFNQ GMLSENPLGF PGYLEKLEKD
110 120 130 140 150
REKTSLNEAV VTGKGTIGGH PAVVAVMDSS FRMGSMGSVV GEKITLAIEK
160 170 180 190 200
AKADKVPFII FTASGGARMQ EGVLSLMQMA KTSSALKLFS EEQGLIISVM
210 220 230 240 250
THPTTGGVSA SFASLGDYNF AEPGALIGFA GRRIIEQTIG EKLPEDFQTA
260 270 280 290
EFLLKHGQLD AVIHRDDMKK TLENLLDMHQ TGGDIEWLQD
Length:290
Mass (Da):32,035
Last modified:October 5, 2016 - v1
Checksum:iE2580113272A9165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017313 Genomic DNA Translation: AOT55517.1
RefSeqiWP_003223544.1, NZ_PVRK01000003.1

Genome annotation databases

EnsemblBacteriaiAOT55517; AOT55517; BH660_10255
PATRICifig|135461.9.peg.3150

Similar proteinsi

Entry informationi

Entry nameiA0A199WK19_BACIU
AccessioniPrimary (citable) accession number: A0A199WK19
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: July 18, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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