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Protein

RNA polymerase II transcription factor B subunit 2

Gene

LY89DRAFT_452072

Organism
Phialocephala scopiformis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:LY89DRAFT_452072Imported
OrganismiPhialocephala scopiformisImported
Taxonomic identifieri149040 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesHelotiales incertae sedisPhialocephala
Proteomesi
  • UP000070700 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A194XLP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSTSASFE YLERLPGVTF RRLYQQPSTA LAIFRRMLPH LAKTFVMALL
60 70 80 90 100
YMTKPLPLTD LDSWVHPNSK RERDQALSLL SRLHIVTITA PSRDDPQTVS
110 120 130 140 150
LTKNFGSSLR LALTGGGEHQ SFGVPSHDVL ANLDTSYLDD YARDQWEGIL
160 170 180 190 200
HYVVASVAEN RGLGSQGPTA SVKKLLEAGK LVTTGRHSGG GITQAGFSFL
210 220 230 240 250
LQEVNAQVWT MLLLWIENAE HMDFDSVEVL SFLFMLGSLE LGRAYSTSTL
260 270 280 290 300
SESQRRMLTY LVDFGLVYVP PSASTQFYPT RLATTLTSDA TALRSVSAGF
310 320 330 340 350
EAALTAASGS KGFIIIETNY RLYAYTNSPL QIAVLALFTK LGTRYPNMVS
360 370 380 390 400
GRITRESVAR AISHGITSDQ IISYLGTHAH PQLVKTSSAN GNPVLPPTVV
410 420 430 440 450
DQIRLWQIEN ERMKATPGFL FRDFENLKEY EACVRYADEI GVLTWKSDAK
460 470
RMFFVTRHEQ LRDYIKSRKT K
Length:471
Mass (Da):52,484
Last modified:October 5, 2016 - v1
Checksum:iD96F61E140E9A42C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ947409 Genomic DNA Translation: KUJ20692.1
RefSeqiXP_018075047.1, XM_018207618.1

Genome annotation databases

EnsemblFungiiKUJ20692; KUJ20692; LY89DRAFT_452072
GeneIDi28817344
KEGGipsco:LY89DRAFT_452072

Similar proteinsi

Entry informationi

Entry nameiA0A194XLP8_9HELO
AccessioniPrimary (citable) accession number: A0A194XLP8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: May 23, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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