Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Crotonobetaine/carnitine--CoA ligase

Gene

caiC

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.UniRule annotation

Catalytic activityi

ATP + 4-(trimethylamino)butanoate + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA.UniRule annotation
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA.UniRule annotation
ATP + crotonobetaine + CoA = AMP + diphosphate + crotonobetainyl-CoA.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported

Enzyme and pathway databases

UniPathwayiUPA00117

Names & Taxonomyi

Protein namesi
Recommended name:
Crotonobetaine/carnitine--CoA ligaseUniRule annotation (EC:6.2.1.48UniRule annotation)
Gene namesi
Name:caiCUniRule annotationImported
ORF Names:AL530_024250Imported, AZZ83_003843Imported, CT143_15555Imported, WM48_00200Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000053643 Componenti: Unassembled WGS sequence
  • UP000194954 Componenti: Unassembled WGS sequence
  • UP000078545 Componenti: Chromosome
  • UP000231393 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A192ELI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 426AMP-bindingInterPro annotationAdd BLAST410
Domaini435 – 510AMP-binding_CInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Family and domain databases

HAMAPiMF_01524 CaiC, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023456 CaiC
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

A0A192ELI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIGGQHLR QMWDDLADVY GHKTALICES SSGVVNRYSY LELNQEINRT
60 70 80 90 100
ANLFYTLGIR KGDKVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLREE
110 120 130 140 150
STWILQNSQA CLLVTSAQFY PMYQQIQQED ASQLRHICLT DMVLPADDGV
160 170 180 190 200
SSFTQLKNQQ PATLCYAPPL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQCA LRDDDVYLTV MPAFHIDCQC TAAMAAFSAG ATFVLVEKYS
260 270 280 290 300
ARAFWGQVQK YRATITECIP MMIRTLMVQP LSANDQQHRL REVMFYLNLS
310 320 330 340 350
EQEKDAFCER FSVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRAGFCYE
360 370 380 390 400
AEIRDDHNRP LPAGELGEIC IKGVPGKTIF KEYFLNPKAT AKVLEADGWL
410 420 430 440 450
HTGDTGYRDE EGFFYFVDRR CNMIKRGGEN VSCVELENII ATHPKIQDIV
460 470 480 490 500
VVGIKDSIRD EAIKAFVVLN EGETLSEEEF FCFCEQNMAK FKVPSYLEIR
510
KDLPRNCSGK IIRKNLK
Length:517
Mass (Da):58,655
Last modified:November 2, 2016 - v1
Checksum:iC66E32D6A3BD27F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014667 Genomic DNA Translation: ANK30799.1
NGSK01000007 Genomic DNA Translation: OUG24673.1
PENR01000008 Genomic DNA Translation: PIM27823.1
LORS02000001 Genomic DNA Translation: PNP65986.1
RefSeqiWP_001298634.1, NZ_PPCP01000045.1

Genome annotation databases

EnsemblBacteriaiANK30799; ANK30799; WM48_00200
PATRICifig|562.10858.peg.893

Similar proteinsi

Entry informationi

Entry nameiA0A192ELI7_ECOLX
AccessioniPrimary (citable) accession number: A0A192ELI7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2016
Last sequence update: November 2, 2016
Last modified: May 23, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health